Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | NPY4R | P50391 | 3/20 | 0.41 |
| ▸ | NPY1R | P25929 | 2/20 | 0.41 |
| ▸ | NPY2R | P49146 | 2/20 | 0.41 |
| ▸ | NPY5R | Q15761 | 2/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.40 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.40 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.40 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25403520 | 1.00 | POLB (0.43) | POLBTDP1ALDH1A1EPHX2NPC1 | |
| Hydrochloric Acid SCHEMBL9618470 | 0.99 | POLB (0.42) | POLBTDP1ALDH1A1EPHX2NPC1 | |
| SCHEMBL6553737 | 0.90 | ITGB3 (0.45) | NPY4RNPY1RNPY2RNPY5RF10 | |
| SCHEMBL16972474 | 0.87 | POLB (0.41) | POLBTDP1EPHX2NPC1RAB9A | |
| Hydrochloric Acid SCHEMBL11211338 | 0.86 | HDAC3 (0.43) | ALDH1A1NPC1RAB9ANPY4RNPY1R | |
| Hydrochloric Acid SCHEMBL11106339 | 0.86 | HDAC3 (0.43) | ALDH1A1NPC1RAB9ANPY4RNPY1R | |
| SCHEMBL8416482 | 0.86 | HDAC1 (0.47) | HDAC1HDAC8HDAC3HDAC4HDAC2 | |
| Bromide SCHEMBL11101365 | 0.85 | HDAC1 (0.46) | HDAC1HDAC8HDAC3HDAC4HDAC2 | |
| SCHEMBL1388522 | 0.83 | CNR1 (0.47) | — | |
| SCHEMBL6864434 | 0.82 | HPGD (0.46) | ALDH1A1NPY4RNPY1RNPY2RNPY5R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1986750-B1 | Use of an extract of Enanthia Chloranta | SEDERMA SA (FR) | 2019-04-24 | — | — | EP | disclosed |
| US-8846019-B2 | Use of protoberberines as an active substance regulating the pilosebaceous unit | SEDERMA (FR) | 2014-09-30 | — | — | US | disclosed |
| US-8591874-B2 | Inhibition of mammalian hair growth | THE PROCTER & GAMBLE COMPANY (US) | 2013-11-26 | — | — | US | disclosed |
| US-8481015-B2 | Applying agmatine and a dermatologically acceptable carrier to the skin; inhibiting hair growth | THE PROCTER & GAMBLE COMPANY (US) | 2013-07-09 | — | — | US | disclosed |
| US-20090269395-A1 | USE OF PROTOBERBERINES AS AN ACTIVE SUBSTANCE REGULATING THE PILOSEBACEOUS UNIT | SEDERMA (FR) | 2009-10-29 | — | — | US | disclosed |
| US-20080188505-A1 | Regulation of Mammalian Hair Growth | OBLONG JOHN ERICH | 2008-08-07 | — | — | US | disclosed |
| US-20080057015-A1 | Hair care compositions, methods, and articles of commerce that can help maintain a longer lasting hair style appearance | THE PROCTER & GAMBLE COMPANY | 2008-03-06 | — | — | US | disclosed |
| US-20070203240-A1 | Personal care compositions and methods for regulating mammalian hair growth | THE PROCTER & GAMBLE COMPANY | 2007-08-30 | — | — | US | disclosed |
| US-20060127431-A1 | Regulation of mammalian hair growth | THE PROCTER & GAMBLE COMPANY | 2006-06-15 | — | — | US | disclosed |
| EP-1601340-A2 | REGULATION OF MAMMALIAN HAIR GROWTH | THE PROCTER & GAMBLE COMPANY (US) | 2005-12-07 | — | — | EP | disclosed |
| US-20050255059-A1 | Personal care compositions and methods regulating mammalian hair growth | PROCTER & GAMBLE COMPANY, THE | 2005-11-17 | — | — | US | disclosed |
| US-20050255060-A1 | Personal care compositions and methods regulating mammalian hair growth | PROCTER & GAMBLE COMPANY, THE | 2005-11-17 | — | — | US | disclosed |
| US-20050003024-A1 | Regulation of mammalian hair growth | THE PROCTER & GAMBLE COMPANY | 2005-01-06 | — | — | US | disclosed |
| WO-2004078157-A2 | REGULATION OF MAMMALIAN HAIR GROWTH | THE PROCTER & GAMBLE COMPANY (US) | 2004-09-16 | — | — | WO | disclosed |
| WO-1999052936-A2 | ARGININE PEPTIDE ANALOGS USEFUL AS FIBROBLAST GROWTH FACTOR ANTAGONISTS | EISAI CO., LTD. (JP) | 1999-10-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050255059-A1 | Personal care compositions and methods regulating mammalian hair growth | PLOD3, MITF, AADAT | POLB 745/4885TDP1 2632/4885ALDH1A1 3562/4885 |
| US-20090269395-A1 | USE OF PROTOBERBERINES AS AN ACTIVE SUBSTANCE REGULATING THE PILOSEBACEOUS UNIT | BROX, CUTA, SHH | POLB 1076/4885TDP1 4382/4885ALDH1A1 3956/4885 |
| US-20060127431-A1 | Regulation of mammalian hair growth | BHMT, UGCG, HNMT | POLB 3376/4885TDP1 3459/4885ALDH1A1 3099/4885 |
| US-20080188505-A1 | Regulation of Mammalian Hair Growth | BHMT, UGCG, HNMT | POLB 3376/4885TDP1 3459/4885ALDH1A1 3099/4885 |
| US-20050255060-A1 | Personal care compositions and methods regulating mammalian hair growth | PCMT1, PLOD3, ARNT | POLB 326/4885TDP1 2413/4885ALDH1A1 3085/4885 |
| US-20050003024-A1 | Regulation of mammalian hair growth | BHMT, UGCG, HNMT | POLB 3376/4885TDP1 3459/4885ALDH1A1 3099/4885 |
| US-20070203240-A1 | Personal care compositions and methods for regulating mammalian hair growth | PLOD1, PLOD3, PLOD2 | POLB 101/4885TDP1 661/4885ALDH1A1 970/4885 |
| US-20080057015-A1 | Hair care compositions, methods, and articles of commerce that can help maintain a longer lasting hair style appearance | SHH, CAPRIN1, CUTA | POLB 3293/4885TDP1 3961/4885ALDH1A1 738/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.