Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 6/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.48 |
| ▸ | LMNA | P02545 | 5/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.48 |
| ▸ | ENPP2 | Q13822 | 2/20 | 0.45 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | XBP1 | P17861 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11547843 | 0.89 | HTT (0.58) | HTTSMN1; SMN2LMNAALDH1A1ENPP2 | |
| SCHEMBL433497 | 0.89 | HTT (0.58) | HTTSMN1; SMN2LMNAALDH1A1NPC1 | |
| SCHEMBL9720036 | 0.89 | HTT (0.58) | HTTSMN1; SMN2LMNAALDH1A1NPC1 | |
| SCHEMBL230747 | 0.87 | ENPP2 (0.56) | ALDH1A1ENPP2PTGS2HSD17B10TDP1 | |
| SCHEMBL924893 | 0.83 | PKM (0.59) | HTTSMN1; SMN2LMNAALDH1A1PTGS2 | |
| SCHEMBL3109128 | 0.83 | HTT (0.61) | HTTSMN1; SMN2LMNAALDH1A1NPC1 | |
| SCHEMBL7363201 | 0.83 | PTGS2 (0.56) | HTTSMN1; SMN2LMNAALDH1A1PTGS2 | |
| SCHEMBL8941654 | 0.83 | PTGS2 (0.56) | HTTSMN1; SMN2LMNAALDH1A1ENPP2 | |
| SCHEMBL7512941 | 0.82 | PTGS2 (0.55) | HTTSMN1; SMN2LMNAALDH1A1ENPP2 | |
| SCHEMBL2758531 | 0.81 | HTT (0.63) | HTTSMN1; SMN2LMNAALDH1A1PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8450427-B2 | Living radical polymerization of activated and nonactivated monomers containing electron-withdrawing side groups | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2013-05-28 | — | — | US | disclosed |
| US-20100331493-A1 | LIVING RADICAL POLYPMERIZATION OF ACTIVATED AND NONACTIVATED MONOMERS CONTAINING ELECTRON-WITHDRAWING SIDE GROUPS | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2010-12-30 | — | — | US | disclosed |
| US-7504537-B2 | Hydroxamic acid derivative and MMP inhibitor containing the same as active ingredient | DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) | 2009-03-17 | — | — | US | disclosed |
| US-7504537-B2 | Hydroxamic acid derivative and MMP inhibitor containing the same as active ingredient | DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) | 2009-03-17 | — | — | US | disclosed |
| US-20070203118-A1 | SUBSTITUTED TETRAHYDROISOQUINOLINES USED IN THE FORM OF MMP INHIBITORS, METHOD FOR THE PRODUCTION AND USE THEREOF IN THE FORM OF DRUGS | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2007-08-30 | — | — | US | disclosed |
| US-20070203118-A1 | SUBSTITUTED TETRAHYDROISOQUINOLINES USED IN THE FORM OF MMP INHIBITORS, METHOD FOR THE PRODUCTION AND USE THEREOF IN THE FORM OF DRUGS | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2007-08-30 | — | — | US | disclosed |
| US-20050282905-A1 | Hydroxamic acid derivative and mmp inhibitor containing the same as active ingredient | DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) | 2005-12-22 | — | — | US | disclosed |
| EP-1466899-A1 | HYDROXAMIC ACID DERIVATIVE AND MMP INHIBITOR CONTAINING THE SAME AS ACTIVE INGREDIENT | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 2004-10-13 | — | — | EP | disclosed |
| US-4505929-A | Sulfur-substituted diphenyl ethers having antiviral activity | THE DOW CHEMICAL COMPANY (US) | 1985-03-19 | — | — | US | disclosed |
| US-4349568-A | Sulfur-substituted diphenyl ethers having antiviral activity | THE DOW CHEMICAL COMPANY (US) | 1982-09-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070203118-A1 | SUBSTITUTED TETRAHYDROISOQUINOLINES USED IN THE FORM OF MMP INHIBITORS, METHOD FOR THE PRODUCTION AND USE THEREOF IN THE FORM OF DRUGS | MMP9, MMP2, MMP3 | HTT 1803/4885SMN1; SMN2 3801/4885LMNA 601/4885 |
| US-20050282905-A1 | Hydroxamic acid derivative and mmp inhibitor containing the same as active ingredient | MMP13, MMP3, MMP2 | HTT 1514/4885SMN1; SMN2 4577/4885LMNA 2272/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.