Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 4/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | NAMPT | P43490 | 1/20 | 0.47 |
| ▸ | HTR2A | P28223 | 2/20 | 0.47 |
| ▸ | HTR2C | P28335 | 2/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.47 |
| ▸ | SFRP1 | Q8N474 | 2/20 | 0.46 |
| ▸ | WNT3 | P56703 | 1/20 | 0.46 |
| ▸ | AR | P10275 | 1/20 | 0.45 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.45 |
| ▸ | PGAM1 | P18669 | 1/20 | 0.44 |
| ▸ | HSPD1 | P10809 | 2/20 | 0.44 |
| ▸ | PTPN2 | P17706 | 2/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.44 |
| ▸ | PTPN5 | P54829 | 2/20 | 0.44 |
| ▸ | HSPE1 | P61604 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4669253 | 0.91 | LMNA (0.45) | HTR6ALDH1A1POLBMAPTSMN1; SMN2 | |
| SCHEMBL15867028 | 0.91 | VCAM1 (0.48) | MAPTNAMPTSLC22A12ARPGAM1 | |
| SCHEMBL19604031 | 0.85 | KIF11 (0.50) | MAPTNAMPTSLC22A12PGAM1HSPD1 | |
| SCHEMBL27841266 | 0.81 | ALDH1A1 (0.63) | HTR6ALDH1A1POLBMAPTSMN1; SMN2 | |
| SCHEMBL586329 | 0.80 | HTR6 (0.58) | HTR6ALDH1A1POLBMAPTSMN1; SMN2 | |
| SCHEMBL4616057 | 0.78 | SFRP1 (0.48) | HTR6ALDH1A1POLBMAPTSMN1; SMN2 | |
| SCHEMBL4618091 | 0.78 | FFAR4 (0.49) | HTR6ALDH1A1POLBMAPTSMN1; SMN2 | |
| SCHEMBL4205464 | 0.78 | HSD17B10 (0.46) | HTR6POLBMAPTNAMPTSLC22A12 | |
| SCHEMBL27080946 | 0.78 | SLC22A12 (0.44) | NAMPTSLC22A12ARERAP1CCR2 | |
| SCHEMBL19599195 | 0.77 | KIF11 (0.47) | MAPTSMN1; SMN2NAMPTERAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101326161-B | Novel compounds | ASTRAZENECA AB | 2013-04-17 | — | — | CN | disclosed |
| US-20090192163-A1 | Novel Compounds | ASTRAZENECA AB (SE) | 2009-07-30 | — | — | US | disclosed |
| CN-101374804-A | Substituted diphenylethers, -amines, -sulfides and -methanes for the treatment of respiratory disease | ASTRAZENECA AB (SE) | 2009-02-25 | — | — | CN | disclosed |
| CN-101326161-A | Novel compounds | ASTRAZENECA AB (SE) | 2008-12-17 | — | — | CN | disclosed |
| US-20080293775-A1 | Substituted Diphenylethers, -Amines, -Sulfides and -Methanes for the Treatment of Respiratory Disease | ASTRAZENECA AB (SE) | 2008-11-27 | — | — | US | disclosed |
| EP-1963259-A2 | SUBSTITUTED DIPHENYLETHERS, -AMINES, -SULFIDES AND -METHANES FOR THE TREATMENT OF RESPIRATORY DISEASE | AstraZeneca AB (SE) | 2008-09-03 | — | — | EP | disclosed |
| WO-2007068894-A2 | SUBSTITUTED DIPHENYLETHERS, -AMINES, -SULFIDES AND -METHANES FOR THE TREATMENT OF RESPIRATORY DISEASE | ASTRAZENECA AB (SE) | 2007-06-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080293775-A1 | Substituted Diphenylethers, -Amines, -Sulfides and -Methanes for the Treatment of Respiratory Disease | PNMT, SQOR, SMS | HTR6 242/4885ALDH1A1 1390/4885POLB 2371/4885 |
| US-20090192163-A1 | Novel Compounds | PAH, PC, DDC | HTR6 253/4885ALDH1A1 128/4885POLB 3105/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.