SCHEMBL434464

SCHEMBL434464

Cc1cc2cc(Cl)ccc2o1

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOB P27338 4/20 0.55
DYRK1A Q13627 1/20 0.50
KDM4E B2RXH2 5/20 0.47
GPR35 Q9HC97 2/20 0.47
ALDH1A1 P00352 2/20 0.47
CYP1A2 P05177 1/20 0.47
CYP2C9 P11712 1/20 0.47
L3MBTL1 Q9Y468 1/20 0.47
CA1 P00915 2/20 0.46
CA2 P00918 2/20 0.46
KMT2A Q03164 1/20 0.46
CA12 O43570 1/20 0.46
CA9 Q16790 1/20 0.46
SMN1; SMN2 Q16637 3/20 0.45
HSD17B10 Q99714 1/20 0.45
APP P05067 1/20 0.44
TSHR P16473 1/20 0.44
ALOX5 P09917 1/20 0.44
HRH4 Q9H3N8 1/20 0.43
LMNA P02545 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8155015 0.83 CA12 (0.50) MAOBDYRK1AKDM4EALDH1A1CYP1A2
SCHEMBL14231749 0.77 MAOB (0.59) MAOBKDM4EGPR35ALDH1A1CYP1A2
SCHEMBL170369 0.77 ALDH1A1 (0.55) MAOBDYRK1AALDH1A1CYP1A2CA1
SCHEMBL12248487 0.75 ALOX5 (0.56) MAOBKDM4EGPR35ALDH1A1CYP1A2
SCHEMBL23920139 0.74 MAOB (0.55) MAOBKDM4EGPR35ALDH1A1CYP1A2
SCHEMBL15031527 0.74 MAOB (0.55) MAOBDYRK1AKDM4EGPR35ALDH1A1
SCHEMBL15031529 0.74 MAOB (0.55) MAOBKDM4EGPR35ALDH1A1CYP1A2
SCHEMBL25824461 0.74 MAOB (0.55) MAOBKDM4EGPR35ALDH1A1CYP1A2
SCHEMBL28117929 0.74 MAOB (0.55) MAOBKDM4EGPR35ALDH1A1CYP1A2
SCHEMBL2090135 0.74 MAOB (0.55) MAOBKDM4EGPR35ALDH1A1CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 146 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230355705-A1 DISCOVERY OF YEATS2 YEATS DOMAIN INHIBITORS AS NOVEL ANTI-CANCER AGENTS THE UNIVERSITY OF HONG KONG (CN) 2023-11-09 US disclosed
US-20230355705-A1 DISCOVERY OF YEATS2 YEATS DOMAIN INHIBITORS AS NOVEL ANTI-CANCER AGENTS THE UNIVERSITY OF HONG KONG (CN) 2023-11-09 US disclosed
US-20230257395-A1 TETRAZOLE DERIVATIVES AS TRPA1 INHIBITORS BOEHRINGER INGELHEIM INT (DE) 2023-08-17 US disclosed
US-20230227438-A1 AZASPIROCYCLES AS MONOACYLGLYCEROL LIPASE MODULATORS JANSSEN PHARMACEUTICA NV (BE) 2023-07-20 US disclosed
EP-3724188-B1 PROGRANULIN MODULATORS AND METHODS OF USING THE SAME ARKUDA THERAPEUTICS (US) 2023-06-07 EP disclosed
US-11661430-B2 Tetrazole derivatives as TRPA1 inhibitors BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2023-05-30 US disclosed
US-11661427-B2 Tetrazole derivatives as TRPA1 inhibitors BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2023-05-30 US disclosed
US-20230047589-A1 INHIBITORS OF INTEGRATED STRESS RESPONSE PATHWAY ALTOS LABS, INC. 2023-02-16 US disclosed
US-11578080-B2 Thienopyrimidones BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2023-02-14 US disclosed
US-20230042881-A1 MODULATORS OF INTEGRATED STRESS RESPONSE PATHWAY Praxis Biotech LLC 2023-02-09 US disclosed
EP-1266897-A2 Hypoglycemic imidazoline compounds ELI LILLY AND COMPANY (US) 2002-12-18 EP disclosed
WO-2002087584-A1 COMBINATIONS OF ALDOSE REDUCTASE INHIBITORS AND CYCLOOXYGENASE-2 INHIBITORS PFIZER PRODUCTS INC. (US) 2002-11-07 WO disclosed
WO-2002079198-A1 PYRIDAZINONE ALDOSE REDUCTASE INHIBITORS PFIZER PRODUCTS INC. (US) 2002-10-10 WO disclosed
US-20020143017-A1 Pyridazinone aldose reductase inhibitors MYLARI BANAVARA L (US) 2002-10-03 US disclosed
US-6410562-B1 ANTIDIABETIC AGENTS ELI LILLY AND COMPANY 2002-06-25 US disclosed
WO-1999032482-A1 HYPOGLYCEMIC IMIDAZOLINE COMPOUNDS ELI LILLY AND COMPANY (US) 1999-07-01 WO disclosed
EP-0924209-A1 Hypoglycemic imidazoline compounds ELI LILLY AND COMPANY (US) 1999-06-23 EP disclosed
EP-0041673-B1 IMIDAZOLE DERIVATIVES, THEIR PREPARATION AND COMPOSITIONS CONTAINING THEM F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) 1984-10-10 EP disclosed
US-4402968-A Antifungal benzofuranyl imidazole compounds HOFFMANN-LA ROCHE INC. (US) 1983-09-06 US disclosed
EP-0041673-A1 Imidazole derivatives, their preparation and compositions containing them F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) 1981-12-16 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230042881-A1 MODULATORS OF INTEGRATED STRESS RESPONSE PATHWAY ATF4, ATF1, DDIT3 MAOB 3095/4885DYRK1A 2583/4885KDM4E 4591/4885
US-11578080-B2 Thienopyrimidones TRPA1, TRPV1, TRPV2 MAOB 2395/4885DYRK1A 3260/4885KDM4E 3740/4885
US-20230257395-A1 TETRAZOLE DERIVATIVES AS TRPA1 INHIBITORS TRPA1, TRPV1, TRPV5 MAOB 3181/4885DYRK1A 1894/4885KDM4E 4765/4885
US-20020143017-A1 Pyridazinone aldose reductase inhibitors SLC5A1, AKR1B1, AKR1D1 MAOB 176/4885DYRK1A 3042/4885KDM4E 2148/4885
US-20230227438-A1 AZASPIROCYCLES AS MONOACYLGLYCEROL LIPASE MODULATORS MGLL, LPAR1, LPL MAOB 17/4885DYRK1A 2115/4885KDM4E 2026/4885
US-20230047589-A1 INHIBITORS OF INTEGRATED STRESS RESPONSE PATHWAY ATF4, DDIT3, ATF1 MAOB 2567/4885DYRK1A 2526/4885KDM4E 4626/4885
US-11661427-B2 Tetrazole derivatives as TRPA1 inhibitors TRPA1, TRPV1, TRPV5 MAOB 3294/4885DYRK1A 1783/4885KDM4E 4764/4885
US-11661430-B2 Tetrazole derivatives as TRPA1 inhibitors TRPA1, TRPV1, TRPV5 MAOB 3294/4885DYRK1A 1783/4885KDM4E 4764/4885
US-20230355705-A1 DISCOVERY OF YEATS2 YEATS DOMAIN INHIBITORS AS NOVEL ANTI-CANCER AGENTS YEATS2, YEATS4, KNTC1 MAOB 3827/4885DYRK1A 1827/4885KDM4E 351/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.