SCHEMBL472288

SCHEMBL472288

O=[N+]([O-])c1cc(C2=NOC(c3cc(Cl)cc(Cl)c3)(C(F)(F)F)C2)ccc1Cl

nearest known ligand 0.38

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
MAPT P10636 5/20 0.37
MEN1 O00255 2/20 0.37
ALDH1A1 P00352 2/20 0.37
KMT2A Q03164 2/20 0.37
DHFR P00374 1/20 0.35
NCOA1 Q15788 1/20 0.35
NCOA3 Q9Y6Q9 1/20 0.35
GRK6 P43250 1/20 0.35
VCAM1 P19320 4/20 0.34
MAPK1 P28482 1/20 0.34
TDP1 Q9NUW8 1/20 0.34
USP2 O75604 1/20 0.33
L3MBTL1 Q9Y468 1/20 0.33
LMNA P02545 1/20 0.33
HTT P42858 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL472625 0.92 LMNA (0.42) MAPTALDH1A1VCAM1USP2LMNA
SCHEMBL739419 0.90 USP2 (0.32) MAPTUSP2LMNAHTT
SCHEMBL472629 0.90 MAPT (0.34) MAPTMEN1ALDH1A1KMT2ATDP1
Ammonia Solution, Strong SCHEMBL27964641 0.89 MAPT (0.33) MAPTMEN1ALDH1A1KMT2ATDP1
SCHEMBL3116206 0.88 VCAM1 (0.44) MAPTVCAM1TDP1USP2LMNA
SCHEMBL19723063 0.88 USP2 (0.31) MAPTUSP2LMNAHTT
SCHEMBL472676 0.88 NCOA1 (0.33) MAPTNCOA1NCOA3USP2LMNA
SCHEMBL737953 0.88 NPC1 (0.35) MAPTMEN1KMT2ATDP1USP2
SCHEMBL1795659 0.88 ALOX12 (0.33) MAPTUSP2
SCHEMBL3120927 0.87 USP2 (0.31) MAPTUSP2LMNAHTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 67 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8785485-B2 Animal ectoparasite-controlling agent SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2014-07-22 US disclosed
US-8785485-B2 Animal ectoparasite-controlling agent SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2014-07-22 US disclosed
US-8785485-B2 Animal ectoparasite-controlling agent SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2014-07-22 US disclosed
EP-2412240-B1 Animal ectoparasite-controlling agent SUMITOMO CHEMICAL CO (JP) 2014-05-07 EP disclosed
EP-2412239-B1 Animal ectoparasite-controlling agent SUMITOMO CHEMICAL CO (JP) 2014-04-16 EP disclosed
EP-2647285-A2 Pest control composition Sumitomo Chemical Company, Limited (JP) 2013-10-09 EP disclosed
US-8507514-B2 Hydrazide compound and use of the same in pest control SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2013-08-13 US disclosed
US-8507514-B2 Hydrazide compound and use of the same in pest control SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2013-08-13 US disclosed
EP-2601835-A1 PEST CONTROL COMPOSITION Sumitomo Chemical Co., Ltd (JP) 2013-06-12 EP disclosed
EP-2601838-A1 PEST CONTROL COMPOSITION Sumitomo Chemical Co., Ltd (JP) 2013-06-12 EP disclosed
US-20110086886-A2 INSECTICIDAL ISOXAZOLINES BAYER CROPSCIENCE AG (DE) 2011-04-14 US disclosed
EP-2308858-A1 Isoxazoline Compounds and their Use in Pest Control Sumitomo Chemical Company, Limited (JP) 2011-04-13 EP disclosed
US-20100249191-A1 N-Methyl benzamide derivatives BAYER CROPSCIENCE SA (FR) 2010-09-30 US disclosed
US-20100137372-A1 ISOXAZOLINE COMPOUNDS AND THEIR USE IN PEST CONTROL SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2010-06-03 US disclosed
US-20100137372-A1 ISOXAZOLINE COMPOUNDS AND THEIR USE IN PEST CONTROL SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2010-06-03 US disclosed
US-20100137372-A1 ISOXAZOLINE COMPOUNDS AND THEIR USE IN PEST CONTROL SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2010-06-03 US disclosed
EP-2139874-A2 ISOXAZOLINE COMPOUNDS AND THEIR USE IN PEST CONTROL Sumitomo Chemical Company, Limited (JP) 2010-01-06 EP disclosed
EP-2069338-A1 INSECTICIDAL ISOXAZOLINES Bayer CropScience AG (DE) 2009-06-17 EP disclosed
WO-2008126665-A2 ISOXAZOLINE COMPOUNDS AND THEIR USE IN PEST CONTROL SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2008-10-23 WO disclosed
WO-2008019760-A1 INSECTICIDAL ISOXAZOLINES BAYER CROPSCIENCE AG (DE) 2008-02-21 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100137372-A1 ISOXAZOLINE COMPOUNDS AND THEIR USE IN PEST CONTROL CYP4X1, PRDX5, PRDX1 MAPT 2335/4885MEN1 4632/4885ALDH1A1 1299/4885
US-20110086886-A2 INSECTICIDAL ISOXAZOLINES HAX1, INA, CYCS MAPT 4845/4885MEN1 4491/4885ALDH1A1 683/4885
US-20100249191-A1 N-Methyl benzamide derivatives GNMT, SCN1A, INA MAPT 4838/4885MEN1 4188/4885ALDH1A1 691/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.