SCHEMBL487232

SCHEMBL487232

O=C(O)c1ccc2c(O)ccnc2c1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 6/20 0.47
KDM4C Q9H3R0 3/20 0.47
MAPT P10636 2/20 0.47
KDM6B O15054 2/20 0.47
KDM4A O75164 2/20 0.47
KDM5C P41229 2/20 0.47
KDM2A Q9Y2K7 2/20 0.47
KDM3A Q9Y4C1 2/20 0.47
ALDH1A1 P00352 2/20 0.47
TET3 O43151 1/20 0.47
BBOX1 O75936 1/20 0.47
KDM5A P29375 1/20 0.47
ASPH Q12797 1/20 0.47
KDM4D Q6B0I6 1/20 0.47
TET2 Q6N021 1/20 0.47
ALKBH5 Q6P6C2 1/20 0.47
KDM7A Q6ZMT4 1/20 0.47
KDM8 Q8N371 1/20 0.47
TET1 Q8NFU7 1/20 0.47
EGLN2 Q96KS0 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14332932 0.86 KDM4E (0.47) KDM4EKDM4CMAPTKDM6BKDM4A
SCHEMBL27619093 0.84 MEN1 (0.38) KDM4EMAPTALDH1A1L3MBTL1POLB
SCHEMBL2810092 0.82 LMNA (0.50) KDM4EKDM4CMAPTKDM6BKDM4A
SCHEMBL6999877 0.81 TDP1 (0.50) KDM4EKDM4CMAPTKDM6BKDM4A
SCHEMBL437621 0.81 NR4A2 (0.54) KDM4EKDM4CMAPTKDM6BKDM4A
SCHEMBL1732368 0.81 SMYD3 (0.49) KDM4EKDM4CMAPTKDM6BKDM4A
SCHEMBL19764526 0.80 ALOX15 (0.54) KDM4EKDM4CMAPTKDM6BKDM5C
SCHEMBL23535248 0.77 CA12 (0.56) KDM4EMAPTALDH1A1L3MBTL1POLB
SCHEMBL6768352 0.75 TDP1 (0.43) KDM4EKDM4CMAPTKDM6BKDM4A
SCHEMBL193423 0.75 MAPT (0.59) KDM4EKDM4CMAPTKDM6BKDM4A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 81 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250275954-A1 USE OF KYNURENIC ACID RESISTING HYPERURICEMIA AND STRUCTURAL ANALOG THEREOF IN PREPARATION OF XOD INHIBITOR UNIV JIMEI (CN) 2025-09-04 US claimed
WO-2025107568-A1 USE OF KYNURENIC ACID IN RESISTING HYPERURICEMIA AND STRUCTURAL ANALOG THEREOF IN PREPARING XOD INHIBITOR 集美大学 2025-05-30 WO claimed
CN-117883445-A Application of hyperuricemia resistance of canine uric acid and structural analogue thereof in preparation of XOD inhibitor 集美大学 2024-04-16 CN claimed
US-12577243-B2 Monoacylglycerol lipase modulators JANSSEN PHARMACEUTICA NV (BE) 2026-03-17 US disclosed
EP-3856178-B1 MONOACYLGLYCEROL LIPASE MODULATORS JANSSEN PHARMACEUTICA NV (BE) 2026-03-11 EP disclosed
US-20250275954-A1 USE OF KYNURENIC ACID RESISTING HYPERURICEMIA AND STRUCTURAL ANALOG THEREOF IN PREPARATION OF XOD INHIBITOR UNIV JIMEI (CN) 2025-09-04 US disclosed
WO-2025107568-A1 USE OF KYNURENIC ACID IN RESISTING HYPERURICEMIA AND STRUCTURAL ANALOG THEREOF IN PREPARING XOD INHIBITOR 集美大学 2025-05-30 WO disclosed
CN-113164459-B Monoacylglycerol lipase modulators 詹森药业有限公司 2024-09-03 CN disclosed
CN-117883445-A Application of hyperuricemia resistance of canine uric acid and structural analogue thereof in preparation of XOD inhibitor 集美大学 2024-04-16 CN disclosed
US-11820766-B2 Monoacylglycerol lipase modulators JANSSEN PHARMACEUTICA NV (BE) 2023-11-21 US disclosed
EP-2552202-B1 METHODS AND COMPOSITIONS FOR WEIGHT LOSS SDG INC (US) 2023-07-26 EP disclosed
WO-2009042945-A1 ORALLY BIOAVAILABLE LIPID-BASED CONSTRUCTS SDG, INC. (AN OHIO CORPORATION ) (US) 2009-04-02 WO disclosed
US-20090087479-A1 Orally bioavailable lipid-based constructs SDG, INC. ( AN OHIO CORPORATION) (US) 2009-04-02 US disclosed
EP-1883394-A2 LIPID CONSTRUCT FOR DELIVERY OF INSULIN TO A MAMMAL SDG, Inc. (US) 2008-02-06 EP disclosed
EP-1883395-A2 LIPID CONSTRUCT FOR DELIVERY OF INTERFERON TO A MAMMAL SDG, Inc. (US) 2008-02-06 EP disclosed
US-20070218117-A1 Supra molecular construct for delivery of interferon to a mammal SDG, INC. 2007-09-20 US disclosed
WO-2006127361-A2 LIPID CONSTRUCT FOR DELIVERY OF INSULIN TO A MAMMAL SDG, INC. (US) 2006-11-30 WO disclosed
WO-2006127360-A2 LIPID CONSTRUCT FOR DELIVERY OF INTERFERON TO A MAMMAL SDG, INC. (US) 2006-11-30 WO disclosed
US-20060222698-A1 Hepatocyte delivery vehicle for delivery of glargine insulin to a mammal SDG, INC. 2006-10-05 US disclosed
US-20060222697-A1 Hepatocyte delivery vehicle for delivery of a combination of recombinant human regular insulin and recombinant human insulin isophane to a mammal SDG, INC. 2006-10-05 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070218117-A1 Supra molecular construct for delivery of interferon to a mammal HAVCR2, IFNAR1, MSR1 KDM4E 4670/4885KDM4C 4519/4885MAPT 4556/4885
US-20250275954-A1 USE OF KYNURENIC ACID RESISTING HYPERURICEMIA AND STRUCTURAL ANALOG THEREOF IN PREPARATION OF XOD INHIBITOR XDH, DAO, KMO KDM4E 1180/4885KDM4C 1872/4885MAPT 4081/4885
US-12577243-B2 Monoacylglycerol lipase modulators MGLL, LPL, FAAH KDM4E 3565/4885KDM4C 3490/4885MAPT 3782/4885
US-20060222698-A1 Hepatocyte delivery vehicle for delivery of glargine insulin to a mammal INSR, GPR119, GCG KDM4E 2544/4885KDM4C 3493/4885MAPT 2171/4885
US-20090087479-A1 Orally bioavailable lipid-based constructs FABP2, FABP1, FABP6 KDM4E 4812/4885KDM4C 4826/4885MAPT 2227/4885
US-11820766-B2 Monoacylglycerol lipase modulators MGLL, LPL, PNLIP KDM4E 2437/4885KDM4C 3010/4885MAPT 2516/4885
US-20060222697-A1 Hepatocyte delivery vehicle for delivery of a combination of recombinant human regular insulin and recombinant human insulin isophane to a mammal INSR, INSRR, IAPP KDM4E 3021/4885KDM4C 4186/4885MAPT 4284/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.