Sugi Predict

Sugi Predict / Compounds / SCHEMBL529516

SCHEMBL529516

SCHEMBL529516

Nc1ccnc(Cl)c1C=O

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 2/20 0.38
▸ MEN1 O00255 1/20 0.38
▸ KMT2A Q03164 1/20 0.38
▸ TDP1 Q9NUW8 1/20 0.38
▸ NR4A2 P43354 3/20 0.37
▸ SOS2 Q07890 1/20 0.37
▸ GAA P10253 1/20 0.35
▸ RAB9A P51151 2/20 0.33
▸ CCR1 P32246 1/20 0.33
▸ CCR5 P51681 1/20 0.33
▸ CCR8 P51685 1/20 0.33
▸ NCF1 P14598 1/20 0.33
▸ KDM4E B2RXH2 3/20 0.33
▸ MAPT P10636 2/20 0.33
▸ LMNA P02545 2/20 0.33
▸ NPSR1 Q6W5P4 1/20 0.32
▸ SMN1; SMN2 Q16637 1/20 0.31
▸ CYP3A4 P08684 1/20 0.31
▸ THRB P10828 1/20 0.31
▸ HPGD P15428 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30937638 1.00 ALDH1A1 (0.38) ALDH1A1MEN1KMT2ATDP1NR4A2
Trifluoroacetic Acid SCHEMBL15669655 0.85 HTT (0.39) RAB9AKDM4ELMNASMN1; SMN2HSD17B10
SCHEMBL31146149 0.81 NR4A2 (0.32) ALDH1A1MEN1KMT2ATDP1NR4A2
SCHEMBL20155325 0.81 NR4A2 (0.36) NR4A2SOS2GAANCF1KDM4E
SCHEMBL8131114 0.80 NOS2 (0.37) ALDH1A1MEN1KMT2ATDP1NR4A2
SCHEMBL29952573 0.78 NOS3 (0.35) ALDH1A1MEN1KMT2ACCR1CCR5
SCHEMBL31184838 0.78 NOS3 (0.35) ALDH1A1MEN1KMT2ACCR1CCR5
SCHEMBL304349 0.77 ALDH1A1 (0.52) ALDH1A1MEN1KMT2ATDP1CCR1
SCHEMBL30255032 0.77 ALDH1A1 (0.52) ALDH1A1MEN1KMT2ATDP1CCR1
SCHEMBL29662072 0.76 L3MBTL1 (0.37) MEN1KMT2ARAB9AKDM4EMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 87 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118388401-B Preparation method of 4-amino-2-chloronicotinaldehyde 成都凯斯坦生物医药有限公司 2024-08-20 — — CN claimed
CN-118388401-A Preparation method of 4-amino-2-chloronicotinaldehyde 成都凯斯坦生物医药有限公司 2024-07-26 — — CN claimed
EP-4688748-A1 QUINOLINONE AMIDE COMPOUNDS AND USES THEREOF EDGEWISE THERAPEUTICS, INC. (US) 2026-02-11 — — EP disclosed
US-20260008774-A1 QUINOLINONE AMIDE COMPOUNDS AND USES THEREOF EDGEWISE THERAPEUTICS INC (US) 2026-01-08 — — US disclosed
US-12509431-B2 1,4-dihydroquinazolinone compounds and uses thereof EDGEWISE THERAPEUTICS, INC. (US) 2025-12-30 — — US disclosed
US-20250361213-A1 1,4-DIHYDROQUINAZOLINONE COMPOUNDS AND USES THEREOF EDGEWISE THERAPEUTICS INC (US) 2025-11-27 — — US disclosed
US-12448369-B2 Quinolinone amide compounds and uses thereof EDGEWISE THERAPEUTICS, INC. (US) 2025-10-21 — — US disclosed
US-20250154111-A1 1,4-DIHYDROQUINAZOLINONE COMPOUNDS AND USES THEREOF EDGEWISE THERAPEUTICS, INC. 2025-05-15 — — US disclosed
US-20250026740-A1 QUINOLINONE AMIDE COMPOUNDS AND USES THEREOF EDGEWISE THERAPEUTICS, INC. 2025-01-23 — — US disclosed
CN-118955502-A Compounds with kinase inhibitory activity 上海赛岚生物科技有限公司 2024-11-15 — — CN disclosed
WO-2024206339-A1 QUINOLINONE AMIDE COMPOUNDS AND USES THEREOF EDGEWISE THERAPEUTICS, INC. (US) 2024-10-03 — — WO disclosed
WO-2008070041-A2 INHIBITORS OF AKT ACTIVITY MERCK & CO., INC. (US) 2008-06-12 — — WO disclosed
WO-2008070041-A2 INHIBITORS OF AKT ACTIVITY MERCK & CO., INC. (US) 2008-06-12 — — WO disclosed
WO-2008070016-A2 INHIBITORS OF AKT ACTIVITY MERCK & CO., INC. (US) 2008-06-12 — — WO disclosed
WO-2008070016-A2 INHIBITORS OF AKT ACTIVITY MERCK & CO., INC. (US) 2008-06-12 — — WO disclosed
EP-1871376-A2 INHIBITORS OF AKT ACTIVITY Merck & Co., Inc. (US) 2008-01-02 — — EP disclosed
EP-1737861-A1 INHIBITORS OF AKT ACTIVITY Merck & Co., Inc. (US) 2007-01-03 — — EP disclosed
WO-2006110638-A2 INHIBITORS OF AKT ACTIVITY MERCK & CO., INC. (US) 2006-10-19 — — WO disclosed
WO-2005100356-A1 INHIBITORS OF AKT ACTIVITY MERCK & CO., INC. (US) 2005-10-27 — — WO disclosed
US-20030004165-A1 Polyazanaphthalene compounds and pharmaceutical use thereof AJINOMOTO CO. INC (JP) 2003-01-02 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12448369-B2 Quinolinone amide compounds and uses thereof TNNI3, TNNT2, COQ8A ALDH1A1 461/4885MEN1 3354/4885KMT2A 2432/4885
US-12509431-B2 1,4-dihydroquinazolinone compounds and uses thereof TNNT2, TNNI3, TNNC1 ALDH1A1 716/4885MEN1 3410/4885KMT2A 3822/4885
US-20030004165-A1 Polyazanaphthalene compounds and pharmaceutical use thereof MMP1, TNF, MMP12 ALDH1A1 998/4885MEN1 2735/4885KMT2A 4169/4885
US-20250026740-A1 QUINOLINONE AMIDE COMPOUNDS AND USES THEREOF TNNI3, TNNT2, COQ8A ALDH1A1 461/4885MEN1 3354/4885KMT2A 2432/4885
US-20250154111-A1 1,4-DIHYDROQUINAZOLINONE COMPOUNDS AND USES THEREOF TNNI3, TNNT2, SDHA ALDH1A1 780/4885MEN1 2996/4885KMT2A 3454/4885
US-20250361213-A1 1,4-DIHYDROQUINAZOLINONE COMPOUNDS AND USES THEREOF TNNI3, TNNT2, SDHA ALDH1A1 780/4885MEN1 2996/4885KMT2A 3454/4885
US-20260008774-A1 QUINOLINONE AMIDE COMPOUNDS AND USES THEREOF TNNT2, TNNI3, TNNC1 ALDH1A1 1031/4885MEN1 4596/4885KMT2A 2983/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.