Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR known ✓ | P00374 | 1/20 | 0.37 |
| ▸ | PTGS2 known ✓ | P35354 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 2/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.35 |
| ▸ | CA2 | P00918 | 3/20 | 0.34 |
| ▸ | CA1 | P00915 | 2/20 | 0.34 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.34 |
| ▸ | CA4 | P22748 | 1/20 | 0.34 |
| ▸ | CA7 | P43166 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | THRB | P10828 | 2/20 | 0.33 |
| ▸ | RECQL | P46063 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27639016 | 0.85 | RAPGEF4 (0.42) | TDP1DHFRTSHRSMN1; SMN2L3MBTL1 | |
| SCHEMBL5776430 | 0.84 | RAPGEF4 (0.41) | TDP1DHFRTSHRSMN1; SMN2L3MBTL1 | |
| Potassium SCHEMBL5776437 | 0.84 | RAPGEF4 (0.41) | TDP1DHFRTSHRSMN1; SMN2L3MBTL1 | |
| SCHEMBL11758764 | 0.80 | L3MBTL1 (0.41) | TDP1DHFRTSHRSMN1; SMN2L3MBTL1 | |
| SCHEMBL29289294 | 0.78 | PRKCI (0.37) | TDP1TSHRL3MBTL1CYP2C19ALDH1A1 | |
| SCHEMBL29080415 | 0.76 | MAPT (0.53) | TDP1TSHRPKMCYP2C19ALOX5 | |
| SCHEMBL11034355 | 0.69 | LMNA (0.44) | SMN1; SMN2CYP2C19CA2CA1CA12 | |
| Potassium Ion SCHEMBL8394450 | 0.69 | L3MBTL1 (0.66) | TDP1TSHRL3MBTL1CA2CA1 | |
| Potassium Ion SCHEMBL28557203 | 0.68 | ALDH1A1 (0.52) | TDP1L3MBTL1PKMCYP2C19CA2 | |
| Potassium Ion SCHEMBL6028409 | 0.68 | L3MBTL1 (0.44) | TDP1TSHRL3MBTL1PKMCA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060142588-A1 | Acetoacetylation of alcohols, thiols and amines in a microreactor | CLARIANT PRODUKTE (DEUTSCHLAND) GMBH (DE) | 2006-06-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060142588-A1 | Acetoacetylation of alcohols, thiols and amines in a microreactor | ADH1A, GRHPR, AKR1C2 | DHFR 28/4885PTGS2 2806/4885TDP1 4248/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.