Sugi Predict

Sugi Predict / Compounds / SCHEMBL5880778

SCHEMBL5880778

SCHEMBL5880778

COc1cc(OC)c(CCC2(C3CCCC3)CC(O)=C(Sc3nc4nc(C)cc(C)n4n3)C(=O)O2)cc1Cl

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 4/20 0.38
▸ SMN1; SMN2 Q16637 3/20 0.38
▸ KMT2A Q03164 1/20 0.38
▸ CYP3A4 P08684 2/20 0.37
▸ CYP2C19 P33261 2/20 0.37
▸ CYP2D6 P10635 1/20 0.37
▸ TSHR P16473 1/20 0.37
▸ MAPK1 P28482 2/20 0.36
▸ HSD17B10 Q99714 2/20 0.36
▸ RECQL P46063 2/20 0.35
▸ ATM Q13315 2/20 0.34
▸ HTT P42858 1/20 0.34
▸ POLB P06746 3/20 0.33
▸ CKS1B P61024 2/20 0.33
▸ SKP2 Q13309 2/20 0.33
▸ L3MBTL1 Q9Y468 1/20 0.33
▸ HPGD P15428 1/20 0.33
▸ USP2 O75604 1/20 0.33
▸ NPSR1 Q6W5P4 1/20 0.33
▸ TDP1 Q9NUW8 2/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5880953 0.90 ALDH1A1 (0.39) ALDH1A1SMN1; SMN2KMT2ACYP3A4CYP2C19
SCHEMBL3992597 0.88 — —
SCHEMBL13939538 0.86 KMT2A (0.35) ALDH1A1SMN1; SMN2KMT2ACYP3A4CYP2C19
SCHEMBL3988390 0.85 — —
SCHEMBL13939709 0.85 IRAK4 (0.31) —
SCHEMBL5880752 0.84 KMT2A (0.41) ALDH1A1SMN1; SMN2KMT2ACYP3A4CYP2C19
SCHEMBL5881044 0.84 KMT2A (0.36) ALDH1A1SMN1; SMN2KMT2ACYP3A4CYP2C19
SCHEMBL6218543 0.82 — —
SCHEMBL3993990 0.82 — —
SCHEMBL3992476 0.81 PDE2A (0.34) ALDH1A1SMN1; SMN2MAPK1HSD17B10POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 68 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260139236-A1 REPROGRAMABLE TNPB POLYPEPTIDES AND USE THEREOF THE BROAD INST INC (US) 2026-05-21 — — US disclosed
US-12630867-B2 Devices for CRISPR effector system based diagnostics THE BROAD INSTITUTE, INC. (US) 2026-05-19 — — US disclosed
US-12618101-B2 Sherlock assays for tick-borne diseases THE BROAD INSTITUTE, INC. (US) 2026-05-05 — — US disclosed
US-20260036583-A1 CRISPR EFFECTOR SYSTEM BASED DIAGNOSTICS FOR HEMORRHAGIC FEVER DETECTION BROAD INST INC (US) 2026-02-05 — — US disclosed
US-12522863-B2 Crispr effector system based coronavirus diagnostics THE BROAD INSTITUTE, INC. (US) 2026-01-13 — — US disclosed
US-12467925-B2 CRISPR effector system based diagnostics for hemorrhagic fever detection THE BROAD INSTITUTE, INC. (US) 2025-11-11 — — US disclosed
US-20250304934-A1 REPROGRAMMABLE FANZOR POLYNUCLEOTIDES AND USES THEREOF THE BROAD INSTITUTE, INC. 2025-10-02 — — US disclosed
US-12415000-B2 CRISPR system based antiviral therapy THE BROAD INSTITUTE, INC. (US) 2025-09-16 — — US disclosed
US-20250243471-A1 PROGRAMMABLE PATTERN RECOGNITION COMPOSITIONS BROAD INST INC (US) 2025-07-31 — — US disclosed
US-20250243248-A1 REPROGRAMMABLE TNPB POLYPEPTIDES WITH MAZE DOMAINS AND USES THEREOF MASSACHUSETTS INSTITUTE OF TECHNOLOGY 2025-07-31 — — US disclosed
WO-2022159892-A1 REPROGRAMMABLE TNPB POLYPEPTIDES AND USE THEREOF THE BROAD INSTITUTE, INC. (US) 2022-07-28 — — WO disclosed
US-20220220546-A1 SHERLOCK ASSAYS FOR TICK-BORNE DISEASES THE BROAD INSTITUTE, INC. 2022-07-14 — — US disclosed
EP-3551753-B1 CRISPR EFFECTOR SYSTEM BASED DIAGNOSTICS BROAD INST INC (US) 2022-06-29 — — EP disclosed
US-20220193010-A1 METHODS OF USING DIPIVEFRIN INSIGNIS THERAPEUTICS INC (US) 2022-06-23 — — US disclosed
WO-2022132955-A2 CORONAVIRUS RAPID DIAGNOSTICS PROOF DIAGNOSTICS, INC. (US) 2022-06-23 — — WO disclosed
US-20220090178-A1 DEVICES FOR CRISPR EFFECTOR SYSTEM BASED DIAGNOSTICS THE BROAD INSTITUTE, INC. (US) 2022-03-24 — — US disclosed
WO-2022051667-A1 CRISPR EFFECTOR SYSTEM BASED DIAGNOSTICS FOR VIRUS DETECTION THE BROAD INSTITUTE, INC. (US) 2022-03-10 — — WO disclosed
US-20220025463-A1 CRISPR EFFECTOR SYSTEM BASED DIAGNOSTICS THE BROAD INSTITUTE, INC. 2022-01-27 — — US disclosed
US-7115658-B2 Inhibitors of hepatitis C virus RNA-dependent RNA polymerase AGOURON PHARMACEUTICALS, INC. (US) 2006-10-03 — — US disclosed
US-20040023958-A1 Inhibitors of hepatitis C virus RNA-dependent RNA polymerase, and compositions and treatments using the same AGOURON PHARMACEUTICALS, INC. 2004-02-05 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260139236-A1 REPROGRAMABLE TNPB POLYPEPTIDES AND USE THEREOF RBM26, TRRAP, RNASEL ALDH1A1 4739/4885SMN1; SMN2 713/4885KMT2A 1142/4885
US-12618101-B2 Sherlock assays for tick-borne diseases CNBP, STUB1, ZFR ALDH1A1 4085/4885SMN1; SMN2 2913/4885KMT2A 2416/4885
US-20220193010-A1 METHODS OF USING DIPIVEFRIN QDPR, DNPEP, DPEP1 ALDH1A1 1423/4885SMN1; SMN2 1532/4885KMT2A 3596/4885
US-20040023958-A1 Inhibitors of hepatitis C virus RNA-dependent RNA polymerase, and compositions and treatments using the same POLRMT, RNGTT, RNASE1 ALDH1A1 729/4885SMN1; SMN2 3990/4885KMT2A 3031/4885
US-20260036583-A1 CRISPR EFFECTOR SYSTEM BASED DIAGNOSTICS FOR HEMORRHAGIC FEVER DETECTION RBM26, SPOUT1, TPR ALDH1A1 3789/4885SMN1; SMN2 1757/4885KMT2A 919/4885
US-12630867-B2 Devices for CRISPR effector system based diagnostics ZFR, MTREX, ADAR ALDH1A1 3908/4885SMN1; SMN2 1024/4885KMT2A 1796/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.