Ro-54864

Ro-54864

SCHEMBL60200

CN1C(=O)CN=C(c2ccc(Cl)cc2)c2cc(Cl)ccc21

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 2/20 1.00
GAA P10253 1/20 1.00
TSPO P30536 1/20 1.00
GABRA1 P14867 9/20 0.85
GABRA5 P31644 9/20 0.85
GABRA2 P47869 9/20 0.85
GABRG2 P18507 8/20 0.85
GABRB3 P28472 8/20 0.85
GABRA3 P34903 8/20 0.85
GABRB2 P47870 6/20 0.85
GABRP O00591 2/20 0.85
GABRD O14764 2/20 0.85
GABRB1 P18505 2/20 0.85
GABRA4 P48169 2/20 0.85
GABRE P78334 2/20 0.85
GABRA6 Q16445 2/20 0.85
GABRG1 Q8N1C3 2/20 0.85
GABRG3 Q99928 2/20 0.85
GABRQ Q9UN88 2/20 0.85
OPRK1 P41145 2/20 0.85

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Ro-54864 SCHEMBL29754019 1.00 LMNA (1.00) LMNAGAATSPOGABRA1GABRA5
SCHEMBL9472656 0.92 LMNA (0.85) LMNAGAATSPOGABRA1GABRA5
SCHEMBL11631556 0.92 LMNA (0.85) LMNAGAATSPOGABRA1GABRA5
Diazepam SCHEMBL16922183 0.92 GABRA1 (1.00) LMNAGAATSPOGABRA1GABRA5
Diazepam SCHEMBL29362687 0.92 GABRA1 (1.00) LMNAGAATSPOGABRA1GABRA5
Diazepam SCHEMBL21442 0.92 GABRA1 (1.00) LMNAGAATSPOGABRA1GABRA5
Diazepam SCHEMBL9278054 0.92 GABRA1 (1.00) LMNAGAATSPOGABRA1GABRA5
Diazepam SCHEMBL1019217 0.92 GABRA1 (1.00) LMNAGAATSPOGABRA1GABRA5
Diazepam SCHEMBL3043280 0.91 GABRA1 (0.97) LMNAGAATSPOGABRA1GABRA5
Diazepam SCHEMBL6014348 0.91 GABRA1 (0.97) LMNAGAATSPOGABRA1GABRA5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 229 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250295611-A1 METHODS OF TREATING 5HT2A RECEPTOR-MEDIATED CONDITIONS TESSELLATE THERAPEUTICS INC (US) 2025-09-25 US claimed
US-20240009200-A1 TREATMENT OF PULMONARY ARTERIAL HYPERTENSION IMPERIAL COLLEGE INNOVATIONS LIMITED (GB) 2024-01-11 US claimed
WO-2023212244-A1 METHODS OF TREATING 5HT2A RECEPTOR-MEDIATED CONDITIONS TESSELLATE THERAPEUTICS, INC. (US) 2023-11-02 WO claimed
EP-4240353-A1 TREATMENT OF PULMONARY ARTERIAL HYPERTENSION Imperial College Innovations Limited (GB) 2023-09-13 EP claimed
WO-2022096901-A1 TREATMENT OF PULMONARY ARTERIAL HYPERTENSION IMPERIAL COLLEGE INNOVATIONS LIMITED (GB) 2022-05-12 WO claimed
CN-111537628-B DPX-GC-MS detection method for 2-chlorodiazepam and 4-chlorodiazepam in urine 无锡微色谱生物科技有限公司 2022-04-26 CN claimed
CN-111537628-A DPX-GC-MS detection method for 2-chlorodiazepam and 4-chlorodiazepam in urine 无锡微色谱生物科技有限公司 2020-08-14 CN claimed
US-20100179133-A1 COMPOSITIONS, ARTICLES AND METHODS COMRISING TSPO LIGANDS FOR PREVENTING OR REDUCING TOBACCO-ASSOCIATED DAMAGE TECHNION RESEARCH & DEVELOPMENT FOUNDATION LTD. (IL) 2010-07-15 US claimed
EP-2170274-A1 COMPOSITIONS, ARTICLES AND METHODS COMPRISING TSPO LIGANDS FOR PREVENTING OR REDUCING TOBACCO-ASSOCIATED DAMAGE Technion Research and Development Foundation, Ltd. (IL) 2010-04-07 EP claimed
WO-2009004621-A1 COMPOSITIONS, ARTICLES AND METHODS COMPRISING TSPO LIGANDS FOR PREVENTING OR REDUCING TOBACCO-ASSOCIATED DAMAGE TECHNION RESEARCH & DEVELOPMENT FOUNDATION LTD. (IL) 2009-01-08 WO claimed
EP-1839657-A2 A method for treating vascular headaches THE GENERAL HOSPITAL CORPORATION (US) 2007-10-03 EP claimed
US-4898861-A ADMINISTERING BENZODIAZEPINE COMPOUNDS, SELECTIVE AFFINITY FOR BINDING SITES ON CELL HOFFMANN-LA ROCHE INC. (US) 1990-02-06 US claimed
US-20260137765-A1 METHODS OF PRODUCING SHIGA TOXIN B-SUBUNIT (STXB) MONOMERS AND OLIGOMERS, AND USES THEREOF INSTITUT CURIE (FR) 2026-05-21 US disclosed
US-12527854-B2 Methods of producing Shiga toxin B-subunit (STxB) monomers and oligomers, and uses thereof INSTITUT CURIE (FR) 2026-01-20 US disclosed
CN-121287718-A Use of Ro5-4864 or a pharmaceutically acceptable salt in the manufacture of a medicament for the treatment and/or prophylaxis of melanocyte depletion disorders resulting from oxidative stress induced inflammatory immune responses 常州大学 2026-01-09 CN disclosed
CN-121287718-A Use of Ro5-4864 or a pharmaceutically acceptable salt in the manufacture of a medicament for the treatment and/or prophylaxis of melanocyte depletion disorders resulting from oxidative stress induced inflammatory immune responses 常州大学 2026-01-09 CN disclosed
EP-0455805-A4 A METHOD OF STIMULATING STEROIDOGENESIS WITH ALPIDEM 1992-05-06 EP disclosed
US-4898861-A ADMINISTERING BENZODIAZEPINE COMPOUNDS, SELECTIVE AFFINITY FOR BINDING SITES ON CELL HOFFMANN-LA ROCHE INC. (US) 1990-02-06 US disclosed
US-4711890-A TREATMENT OF ANXIETY STATES OR OF PULMONARY, RENAL, CIRCULATORY OF CARDIOVASCULAR DISORDERS RHONE-POULENC SANTE (FR) 1987-12-08 US disclosed
US-4684652-A TREATING ANXIETY OR CARDIOVASCULAR DISORDERS RHONE-POULENC SANTE (FR) 1987-08-04 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12527854-B2 Methods of producing Shiga toxin B-subunit (STxB) monomers and oligomers, and uses thereof STXBP1, RNGTT, UPF1 LMNA 757/4885GAA 4002/4885TSPO 2472/4885
US-20260137765-A1 METHODS OF PRODUCING SHIGA TOXIN B-SUBUNIT (STXB) MONOMERS AND OLIGOMERS, AND USES THEREOF STXBP1, HBB, UPF1 LMNA 1243/4885GAA 3170/4885TSPO 1395/4885
US-20250295611-A1 METHODS OF TREATING 5HT2A RECEPTOR-MEDIATED CONDITIONS HTR2A, HTR5A, HTR6 LMNA 1593/4885GAA 681/4885TSPO 1014/4885
US-20100179133-A1 COMPOSITIONS, ARTICLES AND METHODS COMRISING TSPO LIGANDS FOR PREVENTING OR REDUCING TOBACCO-ASSOCIATED DAMAGE TACR2, TSPO, GABRB3 LMNA 987/4885GAA 2097/4885TSPO 2/4885
US-20240009200-A1 TREATMENT OF PULMONARY ARTERIAL HYPERTENSION TSPO, SLC8B1, EDNRB LMNA 1472/4885GAA 3601/4885TSPO 1/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.