Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA2D1 | P54289 | 2/20 | 0.67 |
| ▸ | CACNB3 | P54284 | 1/20 | 0.67 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.67 |
| ▸ | PGR | P06401 | 1/20 | 0.67 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.67 |
| ▸ | HTR2B | P41595 | 1/20 | 0.67 |
| ▸ | CACNA2D2 | Q9NY47 | 1/20 | 0.67 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.41 |
| ▸ | ECE1 | P42892 | 1/20 | 0.37 |
| ▸ | RNPEP | Q9H4A4 | 1/20 | 0.37 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.36 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.36 |
| ▸ | MME | P08473 | 2/20 | 0.36 |
| ▸ | GABRR1 | P24046 | 2/20 | 0.33 |
| ▸ | LAP3 | P28838 | 2/20 | 0.33 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL664033 | 1.00 | CACNA2D1 (0.67) | CACNA2D1CACNB3CACNA1CPGRADRA1A | |
| SCHEMBL664076 | 1.00 | CACNA2D1 (0.67) | CACNA2D1CACNB3CACNA1CPGRADRA1A | |
| SCHEMBL8829767 | 1.00 | CACNA2D1 (0.67) | CACNA2D1CACNB3CACNA1CPGRADRA1A | |
| SCHEMBL9105209 | 0.91 | CACNA2D1 (0.52) | CACNA2D1CACNB3CACNA1CPGRADRA1A | |
| SCHEMBL1410027 | 0.89 | CACNA2D1 (0.74) | CACNA2D1CACNB3CACNA1CPGRADRA1A | |
| Benzene SCHEMBL27913108 | 0.88 | CACNA2D1 (0.58) | CACNA2D1CACNB3CACNA1CPGRADRA1A | |
| SCHEMBL4659755 | 0.86 | CACNA2D1 (0.52) | CACNA2D1CACNB3CACNA1CPGRADRA1A | |
| Ethyl Acetate SCHEMBL28029630 | 0.85 | CACNA2D1 (0.50) | CACNA2D1CACNB3CACNA1CPGRADRA1A | |
| SCHEMBL4412290 | 0.84 | CACNA2D1 (0.74) | CACNA2D1CACNB3CACNA1CPGRADRA1A | |
| SCHEMBL12575347 | 0.83 | CACNA2D1 (0.62) | CACNA2D1CACNB3CACNA1CPGRADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 90 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107428761-A | Prepare dipeptidyl peptidase 4（DPP‑4）The method of inhibitor | 李氏制药有限公司 | 2017-12-01 | — | — | CN | claimed |
| EP-3242879-A1 | NOVEL PROCESS FOR THE PREPARATION OF DIPEPTIDYL PEPTIDASE-4 (DPP-4) ENZYME INHIBITOR | Lee Pharma Ltd. (IN) | 2017-11-15 | — | — | EP | claimed |
| WO-2016110750-A1 | NOVEL PROCESS FOR THE PREPARATION OF DIPEPTIDYL PEPTIDASE-4 (DPP-4) ENZYME INHIBITOR | LEE PHARMA LIMITED (IN) | 2016-07-14 | — | — | WO | claimed |
| CN-105481712-A | Racemization recycling method of Pregabalin intermediate mother liquor from resolution | CHANGZHOU SUNLIGHT PHARM CO LTD | 2016-04-13 | — | — | CN | claimed |
| EP-2035368-B1 | PROCESS FOR THE PREPARATION OF (R)-(-)-3-(CARBAMOYLMETHYL)-5-METHYLHEXANOIC ACID AND OF PREGABALIN AND SYNTHESIS INTERMEDIATES | LABORATORIO CHIMICO INT SPA (IT) | 2015-05-27 | — | — | EP | claimed |
| US-20140323758-A1 | NOVEL PROCESS FOR RACEMIZATION OF AN OPTICALLY ACTIVE (S)-3-CARBAMOYLMETHYL-5-METHYL-HEXANOIC ACID TO CORRESPONDING 3-CARBAMOYLMETHYL-5-METHYL-HEXANOIC ACID RACEMATE | LUPIN LIMITED (IN) | 2014-10-30 | — | — | US | claimed |
| EP-2782901-A1 | NOVEL PROCESS FOR RACEMIZATION OF AN OPTICALLY ACTIVE (S)-3-CARBAMOYLMETHYL-5-METHYL-HEXANOIC ACID TO CORRESPONDING 3-CARBAMOYLMETHYL-5-METHYL-HEXANOIC ACID RACEMATE | Lupin Limited (IN) | 2014-10-01 | — | — | EP | claimed |
| WO-2013076630-A1 | NOVEL PROCESS FOR RACEMIZATION OF AN OPTICALLY ACTIVE (S)-3-CARBAMOYLMETHYL-5-METHYL-HEXANOIC ACID TO CORRESPONDING 3-CARBAMOYLMETHYL-5-METHYL-HEXANOIC ACID RACEMATE | LUPIN LIMITED (IN) | 2013-05-30 | — | — | WO | claimed |
| CN-102126979-A | Preparation method of optically pure 3-(carbamoylmethyl)-5-methyl-hexanoic acid | CHENGDU ORGANIC CHEMICALS CO | 2011-07-20 | — | — | CN | claimed |
| WO-2011077463-A1 | PROCESS FOR PREPARING PREGABALIN AND ITS INTERMEDIATE | MSN LABORATORIES LIMITED (IN) | 2011-06-30 | — | — | WO | claimed |
| CN-101857552-A | Resolution method of 3-(carbamoylmethyl)-5-methylhexanol | CHENGDU ORGANIC CHEMICALS CO | 2010-10-13 | — | — | CN | claimed |
| US-20090192331-A1 | PROCESS FOR THE PREPARATION OF (R)-(-)-3-(CARBAMOYLMETHYL)-5-METHYLHEXANOIC ACID AND OF PREGABALIN AND SYNTHESIS INTERMEDIATES | LABORATORIO CHIMICO INTERNAZIONALE S.P.A. (IT) | 2009-07-30 | — | — | US | claimed |
| EP-2035368-A1 | PROCESS FOR THE PREPARATION OF (R)-(-)-3-(CARBAMOYLMETHYL)-5-METHYLHEXANOIC ACID AND OF PREGABALIN AND SYNTHESIS INTERMEDIATES | Laboratorio Chimico Internazionale S.p.A. (IT) | 2009-03-18 | — | — | EP | claimed |
| WO-2008004044-A1 | PROCESS FOR THE PREPARATION OF (R)-(-)-3-(CARBAMOYLMETHYL)-5-METHYLHEXANOIC ACID AND OF PREGABALIN AND SYNTHESIS INTERMEDIATES | LABORATORIO CHIMICO INTERNAZIONALE S.P.A. (IT) | 2008-01-10 | — | — | WO | claimed |
| EP-0828704-B1 | METHODS OF MAKING (S)-3-(AMINOMETHYL)-5-METHYLHEXANOIC ACID | WARNER LAMBERT CO (US) | 2002-03-13 | — | — | EP | claimed |
| EP-0828704-A1 | METHODS OF MAKING (S)-3-(AMINOMETHYL)-5-METHYLHEXANOIC ACID | WARNER-LAMBERT COMPANY (US) | 1998-03-18 | — | — | EP | claimed |
| US-5629447-A | Methods of making (S)-3-(aminomethyl)-5-methylhexanoic acid | WARNER-LAMBERT COMPANY (US) | 1997-05-13 | — | — | US | claimed |
| US-5616793-A | Methods of making (S)-3-(aminomethyl)-5-methylhexanoic acid | WARNER-LAMBERT COMPANY (US) | 1997-04-01 | — | — | US | claimed |
| WO-1996038405-A1 | METHODS OF MAKING (S)-3-(AMINOMETHYL)-5-METHYLHEXANOIC ACID | WARNER-LAMBERT COMPANY (US) | 1996-12-05 | — | — | WO | claimed |
| CN-116515800-B | PaDP protein and application of mutant thereof in enzymatic synthesis of pregabalin chiral intermediate | 中国科学院微生物研究所 | 2025-06-17 | — | — | CN | disclosed |
| CN-119955872-A | Synthetic protein of R- (-) -3- (carbamoylmethyl) -5-methylhexanoic acid, mutant and application thereof | 中国科学院微生物研究所 | 2025-05-09 | — | — | CN | disclosed |
| US-20250043323-A1 | BIOCATALYSTS AND METHODS FOR THE SYNTHESIS OF PREGABALIN INTERMEDIATES | Enzymaster (Ningbo) Bio-Engineering Co., Ltd (CN) | 2025-02-06 | — | — | US | disclosed |
| CN-114164198-B | (R) - (-) -3- (carbamoylmethyl) -5-methylhexanoic acid synthetic protein, mutant and application thereof | 中国科学院微生物研究所 | 2025-01-07 | — | — | CN | disclosed |
| EP-4433602-A1 | BIOCATALYSTS AND METHODS FOR THE SYNTHESIS OF PREGABALIN INTERMEDIATES | Enzymaster (Ningbo) Bio-Engineering Co., Ltd. (CN) | 2024-09-25 | — | — | EP | disclosed |
| CN-117425732-A | Biocatalysts and methods for synthesizing pregabalin intermediates | 宁波酶赛生物工程有限公司 | 2024-01-19 | — | — | CN | disclosed |
| CN-116515800-A | Application of PaDP protein and mutant thereof in enzymatic synthesis of pregabalin chiral intermediate | 中国科学院微生物研究所 | 2023-08-01 | — | — | CN | disclosed |
| WO-2023088077-A1 | BIOCATALYSTS AND METHODS FOR THE SYNTHESIS OF PREGABALIN INTERMEDIATES | ENZYMASTER (NINGBO) BIO-ENGINEERING CO., LTD. (CN) | 2023-05-25 | — | — | WO | disclosed |
| CN-114164198-A | (R) - (-) -3- (carbamoylmethyl) -5-methylhexanoic acid synthetic protein, mutant and application thereof | 中国科学院微生物研究所 | 2022-03-11 | — | — | CN | disclosed |
| CN-110903228-A | Preparation method of 4-isobutyl pyrrolidone by solvent-free method | 南通常佑药业科技有限公司 | 2020-03-24 | — | — | CN | disclosed |
| EP-3275860-B1 | METHOD FOR PREPARING PREGABALIN INTERMEDIATE 3-CARBAMOYMETHYL-5-METHYLHEXANOIC ACID WITHOUT SOLVENT | ZHEJIANG HUAHAI PHARM CO LTD (CN) | 2020-02-26 | — | — | EP | disclosed |
| CN-107428761-B | The method for preparing dipeptidyl peptidase-4 (DPP-4) inhibitor | 李氏制药有限公司 | 2019-11-05 | — | — | CN | disclosed |
| US-10450315-B2 | Process for the preparation of dipeptidyl peptidase-4 (DPP-4) enzyme inhibitor | LEE PHARMA LIMITED (IN) | 2019-10-22 | — | — | US | disclosed |
| US-10450315-B2 | Process for the preparation of dipeptidyl peptidase-4 (DPP-4) enzyme inhibitor | LEE PHARMA LIMITED (IN) | 2019-10-22 | — | — | US | disclosed |
| EP-2916832-B1 | A PROCESS FOR THE PREPARATION OF PREGABALIN | HIKAL LTD (IN) | 2019-01-16 | — | — | EP | disclosed |
| US-10131625-B2 | Method for preparing 3-carbamoymethyl-5-methylhexanoic acid in recycling way | ZHEJIANG HUAHAI PHARMACEUTICAL CO., LTD. (CN) | 2018-11-20 | — | — | US | disclosed |
| US-20180265513-A1 | NOVEL PROCESS FOR THE PREPARATION OF DIPEPTIDYL PEPTIDASE-4 (DPP-4) ENZYME INHIBITOR | LEE PHARMA LIMITED (IN) | 2018-09-20 | — | — | US | disclosed |
| EP-3275860-A1 | METHOD FOR PREPARING PREGABALIN INTERMEDIATE, 3-CARBAMOYMETHYL-5-METHYLHEXANOIC ACID, USING SOLVENT-FREE REACTION | Zhejiang Huahai Pharmaceutical Co., Ltd (CN) | 2018-01-31 | — | — | EP | disclosed |
| US-20170369422-A1 | METHOD FOR PREPARING PREGABALIN INTERMEDIATE 3-CARBAMOYMETHYL-5-METHYLHEXANOIC ACID WITHOUT SOLVENT | ZHEJIANG HUAHAI PHARMACEUTICAL CO., LTD. (CN) | 2017-12-28 | — | — | US | disclosed |
| CN-107428761-A | Prepare dipeptidyl peptidase 4（DPP‑4）The method of inhibitor | 李氏制药有限公司 | 2017-12-01 | — | — | CN | disclosed |
| US-20170334836-A1 | METHOD FOR PREPARING 3-CARBAMOYMETHYL-5-METHYLHEXANOIC ACID IN RECYCLING WAY | ZHEJIANG HUAHAI PHARMACEUTICAL CO., LTD. (CN) | 2017-11-23 | — | — | US | disclosed |
| US-20170334836-A1 | METHOD FOR PREPARING 3-CARBAMOYMETHYL-5-METHYLHEXANOIC ACID IN RECYCLING WAY | ZHEJIANG HUAHAI PHARMACEUTICAL CO., LTD. (CN) | 2017-11-23 | — | — | US | disclosed |
| EP-3242879-A1 | NOVEL PROCESS FOR THE PREPARATION OF DIPEPTIDYL PEPTIDASE-4 (DPP-4) ENZYME INHIBITOR | Lee Pharma Ltd. (IN) | 2017-11-15 | — | — | EP | disclosed |
| EP-3210967-A1 | METHOD FOR PREPARING 3-CARBAMOYMETHYL-5-METHYLHEXANOIC ACID IN RECYCLING WAY | Zhejiang Huahai Pharmaceutical Co., Ltd (CN) | 2017-08-30 | — | — | EP | disclosed |
| WO-2016110750-A1 | NOVEL PROCESS FOR THE PREPARATION OF DIPEPTIDYL PEPTIDASE-4 (DPP-4) ENZYME INHIBITOR | LEE PHARMA LIMITED (IN) | 2016-07-14 | — | — | WO | disclosed |
| WO-2016110750-A1 | NOVEL PROCESS FOR THE PREPARATION OF DIPEPTIDYL PEPTIDASE-4 (DPP-4) ENZYME INHIBITOR | LEE PHARMA LIMITED (IN) | 2016-07-14 | — | — | WO | disclosed |
| US-9346755-B2 | Kinetic resolution | THE PROVOST, FELLOWS, FOUNDATION SCHOLARS, AND THE OTHER MEMBERS OF BOARD, OF THE COLLEGE OF THE HOLY AND UNDIVIDED TRINITY OF QUEEN ELIZABETH, NEAR DUBLIN TRINITY COLLEGE, UNIVERSITY OF DUBLIN (IE) | 2016-05-24 | — | — | US | disclosed |
| CN-105481712-A | Racemization recycling method of Pregabalin intermediate mother liquor from resolution | CHANGZHOU SUNLIGHT PHARM CO LTD | 2016-04-13 | — | — | CN | disclosed |
| EP-2391600-B1 | INTERMEDIATES IN THE ENANTIOSELECTIVE SYNTHESIS OF 3-(AMINOMETHYL)-5-METHYL-HEXANOIC ACID | PROVOST FELLOWS & SCHOLARS COLLEGE OF THE HOLY UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN (IE) | 2016-01-06 | — | — | EP | disclosed |
| EP-2391600-B1 | INTERMEDIATES IN THE ENANTIOSELECTIVE SYNTHESIS OF 3-(AMINOMETHYL)-5-METHYL-HEXANOIC ACID | PROVOST FELLOWS & SCHOLARS COLLEGE OF THE HOLY UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN (IE) | 2016-01-06 | — | — | EP | disclosed |
| EP-2035368-B1 | PROCESS FOR THE PREPARATION OF (R)-(-)-3-(CARBAMOYLMETHYL)-5-METHYLHEXANOIC ACID AND OF PREGABALIN AND SYNTHESIS INTERMEDIATES | LABORATORIO CHIMICO INT SPA (IT) | 2015-05-27 | — | — | EP | disclosed |
| US-20150073170-A1 | KINETIC RESOLUTION | The Provost, Fellows, Foundation Scholars, and the Other Members of the Board, of the College of the (IE) | 2015-03-12 | — | — | US | disclosed |
| CN-102465157-B | Preparation of pregabalin chiral intermediate with bio-enzyme method | ZHEJIANG JIUZHOU PHARM CO LTD | 2014-11-26 | — | — | CN | disclosed |
| CN-102465157-B | Preparation of pregabalin chiral intermediate with bio-enzyme method | ZHEJIANG JIUZHOU PHARM CO LTD | 2014-11-26 | — | — | CN | disclosed |
| US-20140323758-A1 | NOVEL PROCESS FOR RACEMIZATION OF AN OPTICALLY ACTIVE (S)-3-CARBAMOYLMETHYL-5-METHYL-HEXANOIC ACID TO CORRESPONDING 3-CARBAMOYLMETHYL-5-METHYL-HEXANOIC ACID RACEMATE | LUPIN LIMITED (IN) | 2014-10-30 | — | — | US | disclosed |
| US-20140323758-A1 | NOVEL PROCESS FOR RACEMIZATION OF AN OPTICALLY ACTIVE (S)-3-CARBAMOYLMETHYL-5-METHYL-HEXANOIC ACID TO CORRESPONDING 3-CARBAMOYLMETHYL-5-METHYL-HEXANOIC ACID RACEMATE | LUPIN LIMITED (IN) | 2014-10-30 | — | — | US | disclosed |
| EP-2782901-A1 | NOVEL PROCESS FOR RACEMIZATION OF AN OPTICALLY ACTIVE (S)-3-CARBAMOYLMETHYL-5-METHYL-HEXANOIC ACID TO CORRESPONDING 3-CARBAMOYLMETHYL-5-METHYL-HEXANOIC ACID RACEMATE | Lupin Limited (IN) | 2014-10-01 | — | — | EP | disclosed |
| EP-2782901-A1 | NOVEL PROCESS FOR RACEMIZATION OF AN OPTICALLY ACTIVE (S)-3-CARBAMOYLMETHYL-5-METHYL-HEXANOIC ACID TO CORRESPONDING 3-CARBAMOYLMETHYL-5-METHYL-HEXANOIC ACID RACEMATE | Lupin Limited (IN) | 2014-10-01 | — | — | EP | disclosed |
| US-8563775-B2 | Process for the preparation of (R)-(−)-3-(carbamoylmethyl)-5-methylhexanoic acid and of pregabalin and synthesis intermediates | LABORATORIO CHIMICO INTERNAZIONALE S.P.A. (IT) | 2013-10-22 | — | — | US | disclosed |
| US-8546112-B2 | Process for the stereoselective enzymatic hydrolysis of 5-methyl-3-nitromethyl-hexanoic acid ester | SANDOZ AG (CH) | 2013-10-01 | — | — | US | disclosed |
| US-8546112-B2 | Process for the stereoselective enzymatic hydrolysis of 5-methyl-3-nitromethyl-hexanoic acid ester | SANDOZ AG (CH) | 2013-10-01 | — | — | US | disclosed |
| US-8476441-B2 | Intermediates in the enantioselective synthesis of 3-(aminomethyl)-5-methyl-hexanoic acid | THE PROVOST, FELLOWS AND SCHOLARS OF THE COLLEGE OF THE HOLY AND UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN (IE) | 2013-07-02 | — | — | US | disclosed |
| US-8476441-B2 | Intermediates in the enantioselective synthesis of 3-(aminomethyl)-5-methyl-hexanoic acid | THE PROVOST, FELLOWS AND SCHOLARS OF THE COLLEGE OF THE HOLY AND UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN (IE) | 2013-07-02 | — | — | US | disclosed |
| WO-2013076630-A1 | NOVEL PROCESS FOR RACEMIZATION OF AN OPTICALLY ACTIVE (S)-3-CARBAMOYLMETHYL-5-METHYL-HEXANOIC ACID TO CORRESPONDING 3-CARBAMOYLMETHYL-5-METHYL-HEXANOIC ACID RACEMATE | LUPIN LIMITED (IN) | 2013-05-30 | — | — | WO | disclosed |
| WO-2013076630-A1 | NOVEL PROCESS FOR RACEMIZATION OF AN OPTICALLY ACTIVE (S)-3-CARBAMOYLMETHYL-5-METHYL-HEXANOIC ACID TO CORRESPONDING 3-CARBAMOYLMETHYL-5-METHYL-HEXANOIC ACID RACEMATE | LUPIN LIMITED (IN) | 2013-05-30 | — | — | WO | disclosed |
| CN-101500985-B | Process for the preparation of (R)-(-)-3-(carbamoylmethyl)-5-methylhexanoic acid and of pregabalin and synthesis intermediates | LABORATORIO CHIMICO INT SPA | 2013-04-03 | — | — | CN | disclosed |
| EP-2294207-B1 | Process for the stereoselective enzymatic hydrolysis of 5-methyl-3-nitromethyl-hexanoic acid ester | SANDOZ AG (CH) | 2012-09-26 | — | — | EP | disclosed |
| WO-2012093411-A2 | PROCESS FOR THE PREPARATION OF R-(-)-3- (CARBAMOYLMETHYL)-5-METHYLHEXANOIC ACID AND THE INTERMEDIATES | DR BRAJA SUNDAR PRADHAN (IN) | 2012-07-12 | — | — | WO | disclosed |
| CN-102465157-A | Preparation of pregabalin chiral intermediate by biological enzyme method | ZHEJIANG JIUZHOU PHARM CO LTD | 2012-05-23 | — | — | CN | disclosed |
| CN-102465157-A | Preparation of pregabalin chiral intermediate by biological enzyme method | ZHEJIANG JIUZHOU PHARM CO LTD | 2012-05-23 | — | — | CN | disclosed |
| US-20120046468-A1 | INTERMEDIATES IN THE ENANTIOSELECTIVE SYNTHESIS OF 3-(AMINOMETHYL)-5-METHYL-HEXANOIC ACID | THE PROVOST,FELLOWS AND SCHOLARS OF THE COLLEGE OF THE HOLY LAND AND UNDIVIDED TRINITY OF QUEEN ELIZ (IE) | 2012-02-23 | — | — | US | disclosed |
| US-20120046468-A1 | INTERMEDIATES IN THE ENANTIOSELECTIVE SYNTHESIS OF 3-(AMINOMETHYL)-5-METHYL-HEXANOIC ACID | THE PROVOST,FELLOWS AND SCHOLARS OF THE COLLEGE OF THE HOLY LAND AND UNDIVIDED TRINITY OF QUEEN ELIZ (IE) | 2012-02-23 | — | — | US | disclosed |
| EP-2391600-A2 | INTERMEDIATES IN THE ENANTIOSELECTIVE SYNTHESIS OF 3-(AMINOMETHYL)-5-METHYL-HEXANOIC ACID | The Provost, Fellows and Scholars of the College of the Holy and Undivided Trinity of Queen Elizabeth near Dublin (IE) | 2011-12-07 | — | — | EP | disclosed |
| WO-2011086565-A1 | METHOD FOR PREPARATION OF ENANTIOMERICALLY ENRICHED AND/OR RACEMIC GAMMA-AMINO ACIDS | LUPIN LIMITED (IN) | 2011-07-21 | — | — | WO | disclosed |
| CN-102126979-A | Preparation method of optically pure 3-(carbamoylmethyl)-5-methyl-hexanoic acid | CHENGDU ORGANIC CHEMICALS CO | 2011-07-20 | — | — | CN | disclosed |
| US-20110165636-A1 | PROCESS FOR THE STEREOSELECTIVE ENZYMATIC HYDROLYSIS OF 5-METHYL-3-NITROMETHYL-HEXANOIC ACID ESTER | SANDOZ AG (CH) | 2011-07-07 | — | — | US | disclosed |
| US-20110165636-A1 | PROCESS FOR THE STEREOSELECTIVE ENZYMATIC HYDROLYSIS OF 5-METHYL-3-NITROMETHYL-HEXANOIC ACID ESTER | SANDOZ AG (CH) | 2011-07-07 | — | — | US | disclosed |
| WO-2011077463-A1 | PROCESS FOR PREPARING PREGABALIN AND ITS INTERMEDIATE | MSN LABORATORIES LIMITED (IN) | 2011-06-30 | — | — | WO | disclosed |
| WO-2011077463-A1 | PROCESS FOR PREPARING PREGABALIN AND ITS INTERMEDIATE | MSN LABORATORIES LIMITED (IN) | 2011-06-30 | — | — | WO | disclosed |
| CN-101857552-A | Resolution method of 3-(carbamoylmethyl)-5-methylhexanol | CHENGDU ORGANIC CHEMICALS CO | 2010-10-13 | — | — | CN | disclosed |
| WO-2010086429-A2 | INTERMEDIATES IN THE ENANTIOSELECTIVE SYNTHESIS OF 3-(AMINOMETHYL)-5-METHYL-HEXANOIC ACID | THE PROVOST, FELLOWS AND SCHOLARS OF THE COLLEGE OF THE HOLY AND UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN (IE) | 2010-08-05 | — | — | WO | disclosed |
| EP-2213659-A1 | Intermediates in the Enantioselective Synthesis of 3-(Aminomethyl)-5-Methyl-Hexanoic Acid | The Provost, Fellows and Scholars of the College of the Holy and Undivided Trinity of Queen Elizabeth near Dublin (IE) | 2010-08-04 | — | — | EP | disclosed |
| CN-101500985-A | Process for the preparation of (R)-(-)-3-(carbamoylmethyl)-5-methylhexanoic acid and of pregabalin and synthesis intermediates | LABORATORIO CHIMICO INT SPA (IT) | 2009-08-05 | — | — | CN | disclosed |
| US-20090192331-A1 | PROCESS FOR THE PREPARATION OF (R)-(-)-3-(CARBAMOYLMETHYL)-5-METHYLHEXANOIC ACID AND OF PREGABALIN AND SYNTHESIS INTERMEDIATES | LABORATORIO CHIMICO INTERNAZIONALE S.P.A. (IT) | 2009-07-30 | — | — | US | disclosed |
| EP-2035368-A1 | PROCESS FOR THE PREPARATION OF (R)-(-)-3-(CARBAMOYLMETHYL)-5-METHYLHEXANOIC ACID AND OF PREGABALIN AND SYNTHESIS INTERMEDIATES | Laboratorio Chimico Internazionale S.p.A. (IT) | 2009-03-18 | — | — | EP | disclosed |
| WO-2008004044-A1 | PROCESS FOR THE PREPARATION OF (R)-(-)-3-(CARBAMOYLMETHYL)-5-METHYLHEXANOIC ACID AND OF PREGABALIN AND SYNTHESIS INTERMEDIATES | LABORATORIO CHIMICO INTERNAZIONALE S.P.A. (IT) | 2008-01-10 | — | — | WO | disclosed |
| EP-0828704-B1 | METHODS OF MAKING (S)-3-(AMINOMETHYL)-5-METHYLHEXANOIC ACID | WARNER LAMBERT CO (US) | 2002-03-13 | — | — | EP | disclosed |
| EP-0828704-A1 | METHODS OF MAKING (S)-3-(AMINOMETHYL)-5-METHYLHEXANOIC ACID | WARNER-LAMBERT COMPANY (US) | 1998-03-18 | — | — | EP | disclosed |
| US-5629447-A | Methods of making (S)-3-(aminomethyl)-5-methylhexanoic acid | WARNER-LAMBERT COMPANY (US) | 1997-05-13 | — | — | US | disclosed |
| US-5616793-A | Methods of making (S)-3-(aminomethyl)-5-methylhexanoic acid | WARNER-LAMBERT COMPANY (US) | 1997-04-01 | — | — | US | disclosed |
| WO-1996038405-A1 | METHODS OF MAKING (S)-3-(AMINOMETHYL)-5-METHYLHEXANOIC ACID | WARNER-LAMBERT COMPANY (US) | 1996-12-05 | — | — | WO | disclosed |
| WO-1996038405-A1 | METHODS OF MAKING (S)-3-(AMINOMETHYL)-5-METHYLHEXANOIC ACID | WARNER-LAMBERT COMPANY (US) | 1996-12-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150073170-A1 | KINETIC RESOLUTION | SPR, ADH5, ADH1C | CACNA2D1 4724/4885CACNB3 2975/4885CACNA1C 3442/4885 |
| US-20090192331-A1 | PROCESS FOR THE PREPARATION OF (R)-(-)-3-(CARBAMOYLMETHYL)-5-METHYLHEXANOIC ACID AND OF PREGABALIN AND SYNTHESIS INTERMEDIATES | GABRA5, GRM5, GRIK5 | CACNA2D1 138/4885CACNB3 130/4885CACNA1C 100/4885 |
| US-20170369422-A1 | METHOD FOR PREPARING PREGABALIN INTERMEDIATE 3-CARBAMOYMETHYL-5-METHYLHEXANOIC ACID WITHOUT SOLVENT | GABRG2, GRHPR, GABRG1 | CACNA2D1 63/4885CACNB3 194/4885CACNA1C 49/4885 |
| US-20180265513-A1 | NOVEL PROCESS FOR THE PREPARATION OF DIPEPTIDYL PEPTIDASE-4 (DPP-4) ENZYME INHIBITOR | DPP4, DPP7, DPP9 | CACNA2D1 3416/4885CACNB3 3646/4885CACNA1C 3395/4885 |
| US-20170334836-A1 | METHOD FOR PREPARING 3-CARBAMOYMETHYL-5-METHYLHEXANOIC ACID IN RECYCLING WAY | ALKBH5, ALKBH3, ALKBH1 | CACNA2D1 1330/4885CACNB3 2445/4885CACNA1C 1211/4885 |
| US-20120046468-A1 | INTERMEDIATES IN THE ENANTIOSELECTIVE SYNTHESIS OF 3-(AMINOMETHYL)-5-METHYL-HEXANOIC ACID | FAAH, ALDH7A1, GABRE | CACNA2D1 1001/4885CACNB3 1586/4885CACNA1C 1293/4885 |
| US-10450315-B2 | Process for the preparation of dipeptidyl peptidase-4 (DPP-4) enzyme inhibitor | DPP4, DPP7, DPP3 | CACNA2D1 3426/4885CACNB3 3789/4885CACNA1C 3352/4885 |
| US-20140323758-A1 | NOVEL PROCESS FOR RACEMIZATION OF AN OPTICALLY ACTIVE (S)-3-CARBAMOYLMETHYL-5-METHYL-HEXANOIC ACID TO CORRESPONDING 3-CARBAMOYLMETHYL-5-METHYL-HEXANOIC ACID RACEMATE | ACMSD, HCAR3, ALKBH5 | CACNA2D1 2516/4885CACNB3 894/4885CACNA1C 1411/4885 |
| US-10131625-B2 | Method for preparing 3-carbamoymethyl-5-methylhexanoic acid in recycling way | ALKBH5, ALKBH1, ALKBH3 | CACNA2D1 2188/4885CACNB3 3038/4885CACNA1C 1584/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.