Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRP known ✓ | O00591 | 4/20 | 0.48 |
| ▸ | GABRD known ✓ | O14764 | 4/20 | 0.48 |
| ▸ | GABRA1 known ✓ | P14867 | 4/20 | 0.48 |
| ▸ | GABRB1 known ✓ | P18505 | 4/20 | 0.48 |
| ▸ | GABRG2 known ✓ | P18507 | 4/20 | 0.48 |
| ▸ | GABRB3 known ✓ | P28472 | 4/20 | 0.48 |
| ▸ | GABRA5 known ✓ | P31644 | 4/20 | 0.48 |
| ▸ | GABRA3 known ✓ | P34903 | 4/20 | 0.48 |
| ▸ | GABRA2 known ✓ | P47869 | 4/20 | 0.48 |
| ▸ | GABRB2 known ✓ | P47870 | 4/20 | 0.48 |
| ▸ | GABRA4 known ✓ | P48169 | 4/20 | 0.48 |
| ▸ | GABRE known ✓ | P78334 | 4/20 | 0.48 |
| ▸ | GABRA6 known ✓ | Q16445 | 4/20 | 0.48 |
| ▸ | GABRG1 known ✓ | Q8N1C3 | 4/20 | 0.48 |
| ▸ | GABRG3 known ✓ | Q99928 | 4/20 | 0.48 |
| ▸ | GABRQ known ✓ | Q9UN88 | 4/20 | 0.48 |
| ▸ | TUBB4A known ✓ | P04350 | 1/20 | 0.46 |
| ▸ | TUBB known ✓ | P07437 | 1/20 | 0.46 |
| ▸ | TUBA3C known ✓ | P0DPH7 | 1/20 | 0.46 |
| ▸ | TUBA1B known ✓ | P68363 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29660260 | 0.91 | PLA2G4A (0.58) | MEN1KMT2ANQO2PLA2G4ALTB4R | |
| SCHEMBL6719869 | 0.91 | PLA2G4A (0.58) | MEN1KMT2ANQO2PLA2G4ALTB4R | |
| SCHEMBL3676424 | 0.90 | GPR84 (0.58) | MEN1KMT2ANQO2PLA2G4ALTB4R | |
| SCHEMBL6716658 | 0.90 | PLA2G4A (0.58) | MEN1KMT2ANQO2PLA2G4ALTB4R | |
| SCHEMBL29251326 | 0.88 | MEN1 (0.53) | MEN1KMT2ANQO2PLA2G4ALTB4R | |
| SCHEMBL30844114 | 0.88 | MEN1 (0.53) | MEN1KMT2ANQO2PLA2G4ALTB4R | |
| SCHEMBL30844112 | 0.87 | MEN1 (0.55) | MEN1KMT2ANQO2PLA2G4ALTB4R | |
| SCHEMBL29251786 | 0.87 | MEN1 (0.55) | MEN1KMT2ANQO2PLA2G4ALTB4R | |
| SCHEMBL29251311 | 0.85 | MEN1 (0.46) | MEN1KMT2ANQO2PLA2G4ALTB4R | |
| SCHEMBL30844117 | 0.85 | MEN1 (0.46) | MEN1KMT2ANQO2PLA2G4ALTB4R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040186300-A1 | Process for the preparation of zafirlukast | FINETECH LABORATORIES LTD. (IL) | 2004-09-23 | — | — | US | disclosed |
| WO-2002046153-A2 | PROCESS FOR THE PREPARATION OF ZAFIRLUKAST | FINETECH LABORATORIES LTD. (IL) | 2002-06-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040186300-A1 | Process for the preparation of zafirlukast | LTC4S, LTB4R, CMA1 | GABRP 502/4885GABRD 723/4885GABRA1 145/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.