Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.50 |
| ▸ | MEN1 | O00255 | 7/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.50 |
| ▸ | HPGD | P15428 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 7/20 | 0.48 |
| ▸ | NPC1 | O15118 | 5/20 | 0.48 |
| ▸ | RAB9A | P51151 | 4/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | CASP3 | P42574 | 1/20 | 0.48 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.48 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.48 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1360297 | 0.69 | ALDH1A1 (0.46) | KDM4EALDH1A1MEN1KMT2AHPGD | |
| SCHEMBL70645 | 0.68 | ALDH1A1 (0.42) | KDM4EALDH1A1MEN1KMT2AHPGD | |
| SCHEMBL443517 | 0.68 | LMNA (0.43) | KDM4EKMT2AMAPTNPC1RAB9A | |
| SCHEMBL1201661 | 0.68 | KDM4E (0.55) | KDM4EALDH1A1MEN1KMT2AHPGD | |
| SCHEMBL9454292 | 0.68 | DYRK1A (0.34) | — | |
| SCHEMBL19347423 | 0.68 | CYP1A2 (0.34) | CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL679889 | 0.68 | ALDH1A1 (0.40) | KDM4EALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL498897 | 0.67 | KDM4E (1.00) | KDM4EALDH1A1MEN1KMT2AHPGD | |
| SCHEMBL1379282 | 0.67 | KDM4E (0.48) | KDM4EALDH1A1MEN1KMT2AHPGD | |
| SCHEMBL2710465 | 0.67 | KDM4E (0.48) | KDM4EALDH1A1MEN1KMT2AHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 233 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2592072-B1 | Human protein tyrosine phosphatase inhibitors and their use | AERPIO THERAPEUTICS INC (US) | 2017-09-20 | — | — | EP | claimed |
| EP-2152664-B1 | DIPEPTIDE ANALOGS AS COAGULATION FACTOR INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2014-09-03 | — | — | EP | claimed |
| US-20140243371-A1 | MICROBIOCIDAL PYRAZOLE DERIVATIVES | SYNGENTA PARTICIPATIONS AG (CH) | 2014-08-28 | — | — | US | claimed |
| EP-2768828-A1 | MICROBIOCIDAL PYRAZOLE DERIVATIVES | Syngenta Participations AG (CH) | 2014-08-27 | — | — | EP | claimed |
| EP-2271613-B1 | HYDROXYMETHYLCYCLOHEXYLAMINES | GRUENENTHAL GMBH (DE) | 2014-06-18 | — | — | EP | claimed |
| WO-2013056911-A1 | MICROBIOCIDAL PYRAZOLE DERIVATIVES | SYNGENTA PARTICIPATIONS AG (CH) | 2013-04-25 | — | — | WO | claimed |
| US-8288406-B2 | Hydroxymethylcyclohexylamines | GRUENENTHAL GMBH (DE) | 2012-10-16 | — | — | US | claimed |
| US-20110059999-A1 | Hydroxymethylcyclohexylamines | Grünenthal GmbH (DE) | 2011-03-10 | — | — | US | claimed |
| EP-1863477-B1 | 3,4-SUBSTITUTED PYRROLIDINE DERIVATIVES FOR THE TREATMENT OF HYPERTENSION | NOVARTIS AG (CH) | 2010-11-03 | — | — | EP | claimed |
| EP-2246329-A1 | 4(1H)-pyridinone derivatives and their use as antimalaria agents | Glaxo Group Limited (GB) | 2010-11-03 | — | — | EP | claimed |
| US-7135486-B1 | Adenosine A1, A2a, and A2b receptor ligands; coupling the 2-mercapto-3,5-dicyano-4-aryl-6-aminopyridine to a substituted alkyl or alkenyl compound; antiischemic agents; cardiovascular disorders | BAYER AKTIENGESELISCHAFT (DE) | 2006-11-14 | — | — | US | claimed |
| WO-2006100036-A1 | 3, 4-SUBSTITUTED PYRROLIDINE DERIVATIVES FOR THE TREATMENT OF HYPERTENSION | NOVARTIS AG (CH) | 2006-09-28 | — | — | WO | claimed |
| EP-1368342-B1 | BENZIMIDAZOLE AND PYRIDYLIMIDAZOLE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS | NEUROGEN CORP (US) | 2005-09-07 | — | — | EP | claimed |
| US-20040157834-A1 | Somatostatin antagonists and agonists that act at the SST subtype 2 receptor | PFIZER INC | 2004-08-12 | — | — | US | claimed |
| US-6720330-B2 | INCREASING SECRETION OF GROWTH HORMONE, GASTRIN, OR GLUCAGON IN A MAMMAL; INHIBITING THE BINDING OF SOMATOSTATIN TO AN SST2 RECEPTOR | PFIZER INC. | 2004-04-13 | — | — | US | claimed |
| US-20020091090-A1 | Somatostatin antagonists and agonists | COLE BRIDGET M (US) | 2002-07-11 | — | — | US | claimed |
| US-20020091125-A1 | Somatostatin antagonists and agonists that act at the SST subtype 2 receptor | HAY BRUCE A (US) | 2002-07-11 | — | — | US | claimed |
| EP-0769006-A4 | — | GUILFORD PHARM INC (US) | 1997-05-28 | — | — | EP | claimed |
| EP-0769006-A1 | SMALL MOLECULE INHIBITORS OF ROTAMASE ENZYME ACTIVITY | GUILFORD PHARMACEUTICALS INC. (US) | 1997-04-23 | — | — | EP | claimed |
| US-4551460-A | ANTICOAGULANTS, CARDIOVASCULAR DISORDERS | HOFFMANN-LA ROCHE INC. (US) | 1985-11-05 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110059999-A1 | Hydroxymethylcyclohexylamines | OPRL1, OPRM1, OPRD1 | KDM4E 1466/4885ALDH1A1 610/4885MEN1 3034/4885 |
| US-20140243371-A1 | MICROBIOCIDAL PYRAZOLE DERIVATIVES | ARG1, ARG2, NOX3 | KDM4E 4482/4885ALDH1A1 1214/4885MEN1 913/4885 |
| US-20020091090-A1 | Somatostatin antagonists and agonists | GHSR, GHRHR, SSTR3 | KDM4E 1412/4885ALDH1A1 2908/4885MEN1 882/4885 |
| US-20040157834-A1 | Somatostatin antagonists and agonists that act at the SST subtype 2 receptor | SSTR2, GHSR, SSTR1 | KDM4E 4445/4885ALDH1A1 3746/4885MEN1 1156/4885 |
| US-20020091125-A1 | Somatostatin antagonists and agonists that act at the SST subtype 2 receptor | SSTR2, GHSR, SSTR1 | KDM4E 4346/4885ALDH1A1 3752/4885MEN1 1012/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.