Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | APAF1 | O14727 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | PDE2A | O00408 | 3/20 | 0.35 |
| ▸ | GLS | O94925 | 1/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.32 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | FCGR1A | P12314 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23240257 | 0.82 | SMN1; SMN2 (0.39) | SMN1; SMN2LMNAAPAF1POLBGLS | |
| SCHEMBL24248353 | 0.80 | PDE2A (0.36) | SMN1; SMN2LMNAAPAF1POLBPDE2A | |
| SCHEMBL15686686 | 0.79 | MEN1 (0.42) | SMN1; SMN2LMNAGLSMEN1KMT2A | |
| SCHEMBL2737328 | 0.78 | ALDH1A1 (0.35) | — | |
| SCHEMBL20320308 | 0.77 | LMNA (0.35) | SMN1; SMN2LMNAAPAF1POLB | |
| SCHEMBL10429623 | 0.77 | LMNA (0.45) | SMN1; SMN2LMNAAPAF1POLBKDM4E | |
| SCHEMBL19102161 | 0.76 | GLS (0.34) | SMN1; SMN2LMNAAPAF1POLBGLS | |
| SCHEMBL2508297 | 0.74 | NOS3 (0.33) | — | |
| SCHEMBL22882519 | 0.74 | — | — | |
| SCHEMBL12248406 | 0.74 | RECQL (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 379 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024151638-A2 | COMPOUNDS FOR FGFRS INHIBITORS | COGENT BIOSCIENCES, INC. (US) | 2024-07-18 | — | — | WO | disclosed |
| US-20240218021-A1 | CYCLIN INHIBITORS | CIRCLE PHARMA, INC. | 2024-07-04 | — | — | US | disclosed |
| WO-2024086814-A2 | CYCLIN INHIBITORS | CIRCLE PHARMA, INC. (US) | 2024-04-25 | — | — | WO | disclosed |
| WO-2024020091-A1 | INHIBITORS OF SHORT-CHAIN DEHYDROGENASE ACTIVITY FOR REDUCING GLIAL FIBRILLARY ACIDIC PROTEIN LEVELS | CASE WESTERN RESERVE UNIVERSITY (US) | 2024-01-25 | — | — | WO | disclosed |
| US-11833210-B2 | ASH1L inhibitors and methods of treatment therewith | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2023-12-05 | — | — | US | disclosed |
| US-11833210-B2 | ASH1L inhibitors and methods of treatment therewith | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2023-12-05 | — | — | US | disclosed |
| US-20230357179-A1 | RAF KINASE INHIBITORS AND METHODS OF USE THEREOF | DECIPHERA PHARMACEUTICALS, LLC | 2023-11-09 | — | — | US | disclosed |
| US-11807626-B2 | Compounds and methods for CD73 modulation and indications therefor | Opna Bio SA (CH) | 2023-11-07 | — | — | US | disclosed |
| US-20230348435-A1 | 1-((1H-PYRAZOL-4-YL)METHYL)-3-(PHENYL)-1,3-DIHYDRO-2H-IMIDAZOL-2-ONE DERIVATIVES AND RELATED COMPOUNDS AS GPR139 ANTAGONISTS FOR THE TREATMENT OF E.G. DEPRESSION | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2023-11-02 | — | — | US | disclosed |
| US-20230339980-A1 | COMPOUNDS AND METHODS USEFUL FOR STABILIZING PHENYLALANINE HYDROXYLASE MUTATIONS | AGIOS PHARMACEUTICALS, INC. (US) | 2023-10-26 | — | — | US | disclosed |
| US-20070135631-A1 | HETEROCYCLIC CETP INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY | 2007-06-14 | — | — | US | disclosed |
| US-20070129252-A1 | 2-Halo-6-alkylphenyl-substituted spirocyclic tetramic acid derivatives | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2007-06-07 | — | — | US | disclosed |
| US-20070093391-A1 | 4-Biphenyl-substituted pyrazolidin-3 5-diones pesticide agent and/or microbicide and/or herbicide | BAYER CROPSCIENCE AG (DE) | 2007-04-26 | — | — | US | disclosed |
| US-20070066488-A1 | Hetaryl-substituted pyrazolidindione derivatives with pesticidal characteristics | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2007-03-22 | — | — | US | disclosed |
| US-20070043074-A1 | IMIDAZO[1,2-A] PYRIDINE ANXIOLYTICS | SEPRACOR INC. (US) | 2007-02-22 | — | — | US | disclosed |
| US-20070043074-A1 | IMIDAZO[1,2-A] PYRIDINE ANXIOLYTICS | SEPRACOR INC. (US) | 2007-02-22 | — | — | US | disclosed |
| US-20070032478-A1 | Kinase Inhibitors | ALLERGAN, INC. | 2007-02-08 | — | — | US | disclosed |
| US-20070032478-A1 | Kinase Inhibitors | ALLERGAN, INC. | 2007-02-08 | — | — | US | disclosed |
| US-20070015748-A1 | Kinase Inhibitors | ALLERGAN, INC. | 2007-01-18 | — | — | US | disclosed |
| US-20070015664-A1 | 2,4,6-Phenyl substituted cyclic ketoenols | BAYER CROPSCIENCE AG (DE) | 2007-01-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (14 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070015664-A1 | 2,4,6-Phenyl substituted cyclic ketoenols | CYP4X1, KDM4E, KCNE1 | SMN1; SMN2 4514/4885LMNA 4052/4885APAF1 2978/4885 |
| US-11833210-B2 | ASH1L inhibitors and methods of treatment therewith | ASH1L, DOT1L, ASH2L | SMN1; SMN2 1979/4885LMNA 2874/4885APAF1 1096/4885 |
| US-20070066488-A1 | Hetaryl-substituted pyrazolidindione derivatives with pesticidal characteristics | DDT, CYP1A2, HPD | SMN1; SMN2 4638/4885LMNA 4367/4885APAF1 1626/4885 |
| US-20070093391-A1 | 4-Biphenyl-substituted pyrazolidin-3 5-diones pesticide agent and/or microbicide and/or herbicide | DDT, CYP4X1, HPD | SMN1; SMN2 4748/4885LMNA 4727/4885APAF1 1303/4885 |
| US-20070135631-A1 | HETEROCYCLIC CETP INHIBITORS | CETP, CES1, NPC1 | SMN1; SMN2 4707/4885LMNA 170/4885APAF1 930/4885 |
| US-20070043074-A1 | IMIDAZO[1,2-A] PYRIDINE ANXIOLYTICS | CNR1, CNR2, GABRA5 | SMN1; SMN2 1946/4885LMNA 2323/4885APAF1 4655/4885 |
| US-20230357179-A1 | RAF KINASE INHIBITORS AND METHODS OF USE THEREOF | BRAF, RAF1, ARAF | SMN1; SMN2 3970/4885LMNA 2596/4885APAF1 1123/4885 |
| US-20070129252-A1 | 2-Halo-6-alkylphenyl-substituted spirocyclic tetramic acid derivatives | TBCA, CA6, TRIP13 | SMN1; SMN2 4187/4885LMNA 3066/4885APAF1 3413/4885 |
| US-20240218021-A1 | CYCLIN INHIBITORS | CCNI, CCNC, CDK2 | SMN1; SMN2 2812/4885LMNA 671/4885APAF1 1624/4885 |
| US-20230348435-A1 | 1-((1H-PYRAZOL-4-YL)METHYL)-3-(PHENYL)-1,3-DIHYDRO-2H-IMIDAZOL-2-ONE DERIVATIVES AND RELATED COMPOUNDS AS GPR139 ANTAGONISTS FOR THE TREATMENT OF E.G. DEPRESSION | GPR139, GPR142, HTR2C | SMN1; SMN2 956/4885LMNA 4728/4885APAF1 4768/4885 |
| US-11807626-B2 | Compounds and methods for CD73 modulation and indications therefor | ENTPD5, ENTPD1, ADORA2A | SMN1; SMN2 1115/4885LMNA 1207/4885APAF1 2375/4885 |
| US-20230339980-A1 | COMPOUNDS AND METHODS USEFUL FOR STABILIZING PHENYLALANINE HYDROXYLASE MUTATIONS | PAH, KDM8, PHF8 | SMN1; SMN2 1592/4885LMNA 798/4885APAF1 4313/4885 |
| US-20070015748-A1 | Kinase Inhibitors | ABL1, LCK, ERBB2 | SMN1; SMN2 4664/4885LMNA 4604/4885APAF1 1408/4885 |
| US-20070032478-A1 | Kinase Inhibitors | ABL1, LCK, ERBB2 | SMN1; SMN2 4664/4885LMNA 4604/4885APAF1 1408/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.