Trandolaprilat

Trandolaprilat

SCHEMBL683838

C[C@H](N[C@@H](CCc1ccccc1)C(=O)O)C(=O)N1[C@H](C(=O)O)C[C@@H]2CCCC[C@@H]21

nearest known ligand 0.82

Full drug profile on Sugi Atlas →

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
ACE P12821 14/20 0.82
MEN1 O00255 2/20 0.82
KMT2A Q03164 2/20 0.82
USP2 O75604 1/20 0.82
LMNA P02545 1/20 0.82
CYP3A4 P08684 1/20 0.79
ALOX15 P16050 1/20 0.79

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Trandolaprilat SCHEMBL156829 1.00 ACE (0.82) ACEMEN1KMT2AUSP2LMNA
Trandolaprilat SCHEMBL11076552 1.00 ACE (0.82) ACEMEN1KMT2AUSP2LMNA
Trandolaprilat SCHEMBL678354 1.00 ACE (0.82) ACEMEN1KMT2AUSP2LMNA
Trandolaprilat SCHEMBL5567196 1.00 ACE (0.82) ACEMEN1KMT2AUSP2LMNA
Trandolaprilat SCHEMBL9173132 1.00 ACE (0.82) ACEMEN1KMT2AUSP2LMNA
Trandolaprilat SCHEMBL9173121 1.00 ACE (0.82) ACEMEN1KMT2AUSP2LMNA
Trandolaprilat SCHEMBL11286342 1.00 ACE (0.82) ACEMEN1KMT2AUSP2LMNA
Trandolaprilat SCHEMBL5794079 1.00 ACE (0.82) ACEMEN1KMT2AUSP2LMNA
Trandolaprilat SCHEMBL9173113 1.00 ACE (0.82) ACEMEN1KMT2AUSP2LMNA
Trandolaprilat SCHEMBL7388097 1.00 ACE (0.82) ACEMEN1KMT2AUSP2LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3921420-B1 DRUG DELIVERY COMPOSITIONS FOR OCULAR ADMINISTRATION OF THERAPEUTICS AND METHODS OF USE THEREOF OHIO STATE INNOVATION FOUNDATION (US) 2026-04-08 EP disclosed
US-20260053737-A1 METHODS AND COMPOSITIONS FOR SUSTAINED RELEASE MICROPARTICLES FOR OCULAR DRUG DELIVERY OHIO STATE INNOVATION FOUNDATION (US) 2026-02-26 US disclosed
US-20260007778-A1 METHODS FOR TREATING AND DIAGNOSING BLINDING EYE DISEASES TRANSLATUM MEDICUS INC (CA) 2026-01-08 US disclosed
US-20250387449-A1 PHARMACEUTICAL COMBINATION COMPRISING AN IBAT INHIBITOR AND A BILE ACID BINDER ALBIREO AB (SE) 2025-12-25 US disclosed
EP-4662203-A1 BINDARIT CONJUGATES, COMPOSITIONS AND METHODS FOR TREATING OCULAR DISEASES OR DISORDERS Translatum Medicus Inc. (CA) 2025-12-17 EP disclosed
EP-3956813-B1 DETECTION, PREDICTION, AND CLASSIFICATION FOR OCULAR DISEASE TRACERY OPHTHALMICS INC (CA) 2025-11-26 EP disclosed
US-12377171-B2 Methods for treating and diagnosing blinding eye diseases Translatum Medicus Inc. (CA) 2025-08-05 US disclosed
US-12357564-B2 Methods and compositions for sustained release microparticles for ocular drug delivery OHIO STATE INNOVATION FOUNDATION (US) 2025-07-15 US disclosed
US-20250152781-A1 TISSUE ENGINEERING AND DRUG DELIVERY DEVICE OHIO STATE INNOVATION FOUNDATION 2025-05-15 US disclosed
US-20240335585-A1 TISSUE-ENGINEERED SCAFFOLDS AND METHODS OF MAKING GEORGIA TECH RESEARCH CORPORATION 2024-10-10 US disclosed
US-20220207729-A1 DETECTION, PREDICTION, AND CLASSIFICATION FOR OCULAR DISEASE TRACERY OPHTHALMICS INC. (CA) 2022-06-30 US disclosed
US-20220117888-A1 DRUG DELIVERY COMPOSITIONS FOR OCULAR ADMINISTRATION OF THERAPEUTICS AND METHODS OF USE THEREOF OHIO STATE INNOVATION FOUNDATION 2022-04-21 US disclosed
US-20220118159-A1 ANTIOXIDANT-RELEASING VITREOUS SUBSTITUTES AND USES THEREOF OHIO STATE INNOVATION FOUNDATION 2022-04-21 US disclosed
EP-3956813-A1 DETECTION, PREDICTION, AND CLASSIFICATION FOR OCULAR DISEASE Boyd, Shelley (CA) 2022-02-23 EP disclosed
US-20110269717-A1 NEUROGENESIS BY MODULATING ANGIOTENSIN BRAINCELLS INC. (US) 2011-11-03 US disclosed
US-20110269717-A1 NEUROGENESIS BY MODULATING ANGIOTENSIN BRAINCELLS INC. (US) 2011-11-03 US disclosed
US-20110046090-A1 MODULATION OF NEUROGENESIS WITH GABA AGENTS AND GABA ANALOGS BRAINCELLS INC. (US) 2011-02-24 US disclosed
US-20110046090-A1 MODULATION OF NEUROGENESIS WITH GABA AGENTS AND GABA ANALOGS BRAINCELLS INC. (US) 2011-02-24 US disclosed
US-5225401-A Endopeptidase inhibitors for congestive heart failure E. R. SQUIBB & SONS, INC. (US) 1993-07-06 US disclosed
EP-0527624-A2 Use of a selective inhibitor of neutral endopeptidase and an angiotensin converting enzyme inhibitor in the preparation of a pharmaceutical for treating congestive heart failure E.R. Squibb & Sons, Inc. (US) 1993-02-17 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260053737-A1 METHODS AND COMPOSITIONS FOR SUSTAINED RELEASE MICROPARTICLES FOR OCULAR DRUG DELIVERY ARG1, ARG2, PDE6D ACE 3556/4885MEN1 2591/4885KMT2A 3583/4885
US-20260007778-A1 METHODS FOR TREATING AND DIAGNOSING BLINDING EYE DISEASES AGER, ALDH1A2, RBP1 ACE 1283/4885MEN1 3538/4885KMT2A 4305/4885
US-12357564-B2 Methods and compositions for sustained release microparticles for ocular drug delivery PDE6C, CHMP4B, PDE6D ACE 1928/4885MEN1 1122/4885KMT2A 4733/4885
US-20250387449-A1 PHARMACEUTICAL COMBINATION COMPRISING AN IBAT INHIBITOR AND A BILE ACID BINDER SLC10A2, SLC10A1, ABCB11 ACE 2964/4885MEN1 3166/4885KMT2A 1813/4885
US-20110046090-A1 MODULATION OF NEUROGENESIS WITH GABA AGENTS AND GABA ANALOGS GAP43, GABRB1, GABRB3 ACE 4514/4885MEN1 3647/4885KMT2A 2044/4885
US-12377171-B2 Methods for treating and diagnosing blinding eye diseases ALDH1A2, RBP1, RBP4 ACE 220/4885MEN1 4428/4885KMT2A 4415/4885
US-20110269717-A1 NEUROGENESIS BY MODULATING ANGIOTENSIN NGF, DCX, BDNF ACE 6/4885MEN1 1910/4885KMT2A 1893/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.