Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP14 | P50281 | 2/20 | 0.38 |
| ▸ | MMP13 | P45452 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 6/20 | 0.37 |
| ▸ | MAOA | P21397 | 5/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | PGR | P06401 | 2/20 | 0.35 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.35 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.35 |
| ▸ | KIF11 | P52732 | 1/20 | 0.34 |
| ▸ | MMP3 | P08254 | 2/20 | 0.33 |
| ▸ | MMP2 | P08253 | 2/20 | 0.33 |
| ▸ | MMP9 | P14780 | 1/20 | 0.33 |
| ▸ | MMP8 | P22894 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7199008 | 1.00 | MMP14 (0.38) | MMP14MMP13MAOBMAOASMN1; SMN2 | |
| SCHEMBL6841100 | 0.83 | ALDH1A1 (0.46) | SMN1; SMN2ALDH1A1NPSR1MMP3MMP2 | |
| SCHEMBL12378669 | 0.81 | ALDH1A1 (0.42) | SMN1; SMN2ALDH1A1NPSR1MMP2MMP9 | |
| SCHEMBL12378821 | 0.79 | ADAMTS5 (0.43) | MMP14MMP13MAOBMAOASMN1; SMN2 | |
| SCHEMBL6210406 | 0.79 | ADAMTS5 (0.43) | MMP14MMP13MAOBMAOASMN1; SMN2 | |
| SCHEMBL6876082 | 0.78 | MMP13 (0.47) | MMP14MMP13SMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL941823 | 0.76 | MMP13 (0.46) | MMP14MMP13SMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL941821 | 0.75 | MMP2 (0.49) | MMP14MMP13SMN1; SMN2NOTUMNPSR1 | |
| SCHEMBL2872428 | 0.70 | POLB (0.52) | MMP14MMP13SMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL2872659 | 0.69 | GRIA1 (0.46) | MMP13MMP3MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040147573-A1 | Metalloproteinase inhibitors | ASTRAZENECA AB (SE) | 2004-07-29 | — | — | US | disclosed |
| US-20040106659-A1 | Metalloproteinase inhibitors | ASTRAZENECA AB (SE) | 2004-06-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040106659-A1 | Metalloproteinase inhibitors | MMP9, TIMP3, MMP11 | MMP14 6/4885MMP13 11/4885MAOB 270/4885 |
| US-20040147573-A1 | Metalloproteinase inhibitors | MMP12, MMP7, MMP10 | MMP14 10/4885MMP13 19/4885MAOB 123/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.