Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | MMP2 | P08253 | 6/20 | 0.44 |
| ▸ | MMP9 | P14780 | 5/20 | 0.44 |
| ▸ | MMP3 | P08254 | 1/20 | 0.44 |
| ▸ | MMP8 | P22894 | 2/20 | 0.41 |
| ▸ | LIPG | Q9Y5X9 | 2/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | ADAMTS5 | Q9UNA0 | 3/20 | 0.39 |
| ▸ | LIPC | P11150 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | HRH1 | P35367 | 1/20 | 0.38 |
| ▸ | SCN1A | P35498 | 1/20 | 0.38 |
| ▸ | SCN4A | P35499 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12378669 | 0.86 | ALDH1A1 (0.42) | ALDH1A1MMP2MMP9LIPGADAMTS5 | |
| SCHEMBL12378821 | 0.83 | ADAMTS5 (0.43) | ALDH1A1MMP2MMP9MMP3ADAMTS5 | |
| SCHEMBL6210406 | 0.83 | ADAMTS5 (0.43) | ALDH1A1MMP2ADAMTS5SMN1; SMN2NPSR1 | |
| SCHEMBL6879272 | 0.83 | MMP14 (0.38) | ALDH1A1MMP2MMP9MMP3MMP8 | |
| SCHEMBL7199008 | 0.83 | MMP14 (0.38) | ALDH1A1MMP2MMP9MMP3MMP8 | |
| SCHEMBL941821 | 0.80 | MMP2 (0.49) | MMP2MMP9MMP3MMP8SMN1; SMN2 | |
| SCHEMBL14085483 | 0.75 | ALDH1A1 (0.45) | ALDH1A1MMP2MMP9MMP3MMP8 | |
| SCHEMBL12416702 | 0.75 | ALDH1A1 (0.48) | ALDH1A1MMP2MMP9MMP3MMP8 | |
| SCHEMBL944078 | 0.74 | ALDH1A1 (0.57) | ALDH1A1MMP2MMP9MMP8ADAMTS5 | |
| SCHEMBL941900 | 0.74 | ALDH1A1 (0.57) | ALDH1A1MMP2MMP9MMP8ADAMTS5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080226618-A1 | HYDANTOIN DERIVATIVES USEFUL AS ANTIBACTERIAL AGENTS | SCHERING CORPORATION | 2008-09-18 | — | — | US | disclosed |
| US-20040147573-A1 | Metalloproteinase inhibitors | ASTRAZENECA AB (SE) | 2004-07-29 | — | — | US | disclosed |
| US-20040106659-A1 | Metalloproteinase inhibitors | ASTRAZENECA AB (SE) | 2004-06-03 | — | — | US | disclosed |
| EP-1370536-A1 | METALLOPROTEINASE INHIBITORS | AstraZeneca AB (SE) | 2003-12-17 | — | — | EP | disclosed |
| WO-2002074750-A1 | METALLOPROTEINASE INHIBITORS | ASTRAZENECA AB (SE) | 2002-09-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080226618-A1 | HYDANTOIN DERIVATIVES USEFUL AS ANTIBACTERIAL AGENTS | LPXN, HAX1, LCT | ALDH1A1 1419/4885MMP2 1337/4885MMP9 1850/4885 |
| US-20040106659-A1 | Metalloproteinase inhibitors | MMP9, TIMP3, MMP11 | ALDH1A1 712/4885MMP2 9/4885MMP9 1/4885 |
| US-20040147573-A1 | Metalloproteinase inhibitors | MMP12, MMP7, MMP10 | ALDH1A1 1250/4885MMP2 11/4885MMP9 8/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.