Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 1/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.66 |
| ▸ | ATM | Q13315 | 1/20 | 0.66 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.65 |
| ▸ | CTNNB1 | P35222 | 5/20 | 0.64 |
| ▸ | WNT3A | P56704 | 5/20 | 0.64 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.61 |
| ▸ | LMNA | P02545 | 1/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.57 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.56 |
| ▸ | NPC1 | O15118 | 2/20 | 0.55 |
| ▸ | RAB9A | P51151 | 2/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30839501 | 1.00 | ADAM17 (0.66) | ADAM17ALDH1A1ATMGPR84CTNNB1 | |
| Hydrochloric Acid SCHEMBL20509735 | 0.98 | ADAM17 (0.64) | ADAM17ALDH1A1ATMGPR84CTNNB1 | |
| Bromide SCHEMBL7244503 | 0.98 | ADAM17 (0.64) | ADAM17ALDH1A1ATMGPR84CTNNB1 | |
| Acetic Acid SCHEMBL28541136 | 0.94 | ADAM17 (0.63) | ADAM17ALDH1A1ATMGPR84CTNNB1 | |
| SCHEMBL4056357 | 0.84 | ADAM17 (0.68) | ADAM17ALDH1A1ATMGPR84CTNNB1 | |
| SCHEMBL32685253 | 0.84 | ADAM17 (0.68) | ADAM17ALDH1A1ATMGPR84CTNNB1 | |
| SCHEMBL3717752 | 0.84 | ADAM17 (0.68) | ADAM17ALDH1A1ATMGPR84CTNNB1 | |
| SCHEMBL3122183 | 0.83 | ALDH1A1 (0.67) | ADAM17ALDH1A1ATMGPR84CTNNB1 | |
| SCHEMBL1903034 | 0.82 | ADAM17 (0.66) | ADAM17ALDH1A1ATMGPR84CTNNB1 | |
| SCHEMBL31295276 | 0.82 | ADAM17 (0.66) | ADAM17ALDH1A1ATMGPR84CTNNB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110218206-B | Bisindolylmaleimide derivative and preparation method and application thereof | 中国海洋大学 | 2022-03-04 | — | — | CN | claimed |
| CN-1064359-C | Diindole heterocyclic compounds, preparing method and use thereof | SHANGHAI INST ORGANIC CHEM (CN) | 2001-04-11 | — | — | CN | claimed |
| CN-1224015-A | Diindole heterocyclic compounds, preparing method and use thereof | SHANGHAI INST ORGANIC CHEM (CN) | 1999-07-28 | — | — | CN | claimed |
| WO-2024133499-A1 | GLYCINE DERIVATIVES WITH P2X4 RECEPTOR-BLOCKING ACTIVITY AS DIAGNOSTICS AND FOR THE TREATMENT OF PAIN, INFLAMMATION, CANCER, AND OTHER P2X4 RECEPTOR-RELATED DISEASES | RHEINISCHE-FRIEDRICH-WILHELMS-UNIVERSITÄT BONN (DE) | 2024-06-27 | — | — | WO | disclosed |
| US-20240124408-A1 | Substituted Cyclohexanecarboxamides, Their Preparation and Their Therapeutic Application | SANOFI (FR) | 2024-04-18 | — | — | US | disclosed |
| US-20230263155-A1 | 5-(1H-INDOL-3-YL)-OXAZOLE, -OXADIAZOLE AND -FURAN DERIVATIVES AS ENHANCERS OF SPERM MOTILITY | SPERMATECH AS (NO) | 2023-08-24 | — | — | US | disclosed |
| US-20230263155-A1 | 5-(1H-INDOL-3-YL)-OXAZOLE, -OXADIAZOLE AND -FURAN DERIVATIVES AS ENHANCERS OF SPERM MOTILITY | SPERMATECH AS (NO) | 2023-08-24 | — | — | US | disclosed |
| US-20230257347-A1 | ADVANTAGEOUS TRYPTAMINE COMPOSITIONS FOR MENTAL DISORDERS OR ENHANCEMENT | TACTOGEN INC (US) | 2023-08-17 | — | — | US | disclosed |
| EP-4214192-A1 | ADVANTAGEOUS TRYPTAMINE COMPOSITIONS FOR MENTAL DISORDERS OR ENHANCEMENT | Tactogen Inc. (US) | 2023-07-26 | — | — | EP | disclosed |
| WO-2022061242-A1 | ADVANTAGEOUS TRYPTAMINE COMPOSITIONS FOR MENTAL DISORDERS OR ENHANCEMENT | TACTOGEN INC (US) | 2022-03-24 | — | — | WO | disclosed |
| CN-110218206-B | Bisindolylmaleimide derivative and preparation method and application thereof | 中国海洋大学 | 2022-03-04 | — | — | CN | disclosed |
| US-8993588-B2 | Carboxamide heterocyclic CGRP receptor antagonists | MERCK SHARP & DOHME CORP. (US) | 2015-03-31 | — | — | US | disclosed |
| US-20100179166-A1 | CARBOXAMIDE HETEROCYCLIC CGRP RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME LLC | 2010-07-15 | — | — | US | disclosed |
| US-20100179166-A1 | CARBOXAMIDE HETEROCYCLIC CGRP RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME LLC | 2010-07-15 | — | — | US | disclosed |
| US-7615638-B2 | Synthesis of grossularines-1 and analogs thereof and method of use | CITY OF HOPE (US) | 2009-11-10 | — | — | US | disclosed |
| US-7615638-B2 | Synthesis of grossularines-1 and analogs thereof and method of use | CITY OF HOPE (US) | 2009-11-10 | — | — | US | disclosed |
| US-20080033004-A1 | SYNTHESIS OF GROSSULARINES-1 AND ANALOGS THEREOF AND METHOD OF USE | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2008-02-07 | — | — | US | disclosed |
| EP-1042317-B1 | Indole derivatives as PKC-inhiboitors | ASTRAZENECA AB (SE) | 2003-05-14 | — | — | EP | disclosed |
| EP-1042317-A1 | NEW PHARMACEUTICALLY ACTIVE COMPOUNDS | AstraZeneca AB (SE) | 2000-10-11 | — | — | EP | disclosed |
| WO-1999032483-A1 | NEW PHARMACEUTICALLY ACTIVE COMPOUNDS | ASTRAZENECA AB (SE) | 1999-07-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230263155-A1 | 5-(1H-INDOL-3-YL)-OXAZOLE, -OXADIAZOLE AND -FURAN DERIVATIVES AS ENHANCERS OF SPERM MOTILITY | NR5A1, NR1I3, NR5A2 | ADAM17 3480/4885ALDH1A1 1219/4885ATM 3385/4885 |
| US-20240124408-A1 | Substituted Cyclohexanecarboxamides, Their Preparation and Their Therapeutic Application | TRPM8, TAS2R8, TRPM7 | ADAM17 2249/4885ALDH1A1 3565/4885ATM 2756/4885 |
| US-20100179166-A1 | CARBOXAMIDE HETEROCYCLIC CGRP RECEPTOR ANTAGONISTS | BDKRB1, BDKRB2, CCKBR | ADAM17 2396/4885ALDH1A1 1925/4885ATM 4019/4885 |
| US-20080033004-A1 | SYNTHESIS OF GROSSULARINES-1 AND ANALOGS THEREOF AND METHOD OF USE | INMT, GNMT, HTR5A | ADAM17 1970/4885ALDH1A1 361/4885ATM 4238/4885 |
| US-20230257347-A1 | ADVANTAGEOUS TRYPTAMINE COMPOSITIONS FOR MENTAL DISORDERS OR ENHANCEMENT | HTR6, TPH2, TPH1 | ADAM17 1427/4885ALDH1A1 3674/4885ATM 2259/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.