Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Dihydrolipoic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 known ✓ | P00915 | 3/20 | 0.40 |
| ▸ | CA2 known ✓ | P00918 | 1/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.38 |
| ▸ | GSTK1 | Q9Y2Q3 | 2/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.33 |
| ▸ | ENPEP | Q07075 | 1/20 | 0.33 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.33 |
| ▸ | BBOX1 | O75936 | 1/20 | 0.33 |
| ▸ | FABP3 | P05413 | 2/20 | 0.32 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.32 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.32 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.32 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.32 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dihydrolipoic Acid SCHEMBL2582100 | 0.96 | NFKB1 (0.39) | NFKB1CA1GPR84CA2GSTK1 | |
| Dihydrolipoic Acid SCHEMBL5827361 | 0.96 | NFKB1 (0.39) | NFKB1CA1GPR84CA2GSTK1 | |
| Dihydrolipoic Acid SCHEMBL1659440 | 0.96 | NFKB1 (0.39) | NFKB1CA1GPR84GSTK1ENPEP | |
| Dihydrolipoic Acid SCHEMBL4761909 | 0.94 | NFKB1 (0.38) | NFKB1CA1GPR84CA2GSTK1 | |
| Dihydrolipoic Acid SCHEMBL4094129 | 0.93 | GSTK1 (0.46) | NFKB1GSTK1ENPEPFOLH1 | |
| SCHEMBL3276879 | 0.86 | HDAC3 (0.36) | NFKB1HDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL3276632 | 0.84 | HDAC3 (0.41) | HDAC3HDAC1HDAC2HDAC8HDAC4 | |
| Dihydrolipoic Acid SCHEMBL715539 | 0.84 | NFKB1 (0.33) | NFKB1CA1 | |
| SCHEMBL19951022 | 0.83 | NFKB1 (0.39) | NFKB1CA1GPR84HDAC3HDAC1 | |
| Tetrabuthylammonium SCHEMBL7185399 | 0.82 | NFKB1 (0.47) | NFKB1CA1GPR84CA2BBOX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 136 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12364656-B2 | Depilatory compositions comprising aminoalkylpropanol | Reckitt Benckiser Health Limited (GB) | 2025-07-22 | — | — | US | claimed |
| US-20250161178-A1 | DEPILATORY COMPOSITIONS COMPRISING AMINOALKYLPROPANOL | Reckitt Benckiser Health Limited (GB) | 2025-05-22 | — | — | US | claimed |
| US-20220265536-A1 | Depilatory Compositions Comprising Aminoalkylpropanol | RECKITT BENCKISER (BRANDS) LIMITED (GB) | 2022-08-25 | — | — | US | claimed |
| US-9795558-B2 | Depilatory formulations and methods of using same | RECKITT & COLMAN (OVERSEAS) LIMITED (GB) | 2017-10-24 | — | — | US | claimed |
| US-9573001-B2 | Depilatory composition | RECKITT & COLMAN (OVERSEAS) LIMITED (GB) | 2017-02-21 | — | — | US | claimed |
| EP-2155808-B1 | METHOD FOR TREATING THE SURFACE OF A SUBSTRATE BASED ON SULPHUR POLYMER, INTENDED TO BE COVERED WITH A COATING | ESSILOR INT (COMPAGNIE GÉNÉRALE D'OPTIQUE) (FR) | 2016-12-14 | — | — | EP | claimed |
| CN-105534743-A | DEPILATORY COMPOSITION | RECKITT & COLMAN OVERSEAS | 2016-05-04 | — | — | CN | claimed |
| CN-102985057-B | Improvements in or relating to depilatory compositions | RECKITT & COLMAN (OVERSEAS) LTD. (GB) | 2016-02-03 | — | — | CN | claimed |
| US-9110223-B2 | Method for treating the surface of a substrate based on sulphur polymer, intended to be covered with a coating | ESSILOR INTERNATIONAL (COMPAGNIE GENERALE D'OPTIQUE) (FR) | 2015-08-18 | — | — | US | claimed |
| US-20150202140-A1 | Depilatory Formulations And Methods Of Using Same | RECKITT & COLMAN (OVERSEAS) HEALTH LIMITED (GB) | 2015-07-23 | — | — | US | claimed |
| WO-2008155507-A1 | METHOD FOR TREATING THE SURFACE OF A SUBSTRATE BASED ON SULPHUR POLYMER, INTENDED TO BE COVERED WITH A COATING | ESSILOR INTERNATIONAL (COMPAGNIE GENERALE D'OPTIQUE) (FR) | 2008-12-24 | — | — | WO | claimed |
| US-20080260671-A1 | Depilatory Compositions | RECKITT BENCKISER (UK) LIMITED (GB) | 2008-10-23 | — | — | US | claimed |
| EP-1765270-B1 | IMPROVEMENTS IN OR RELATING TO DEPILATORY COMPOSITIONS | RECKITT BENCKISER UK LTD (GB) | 2008-09-17 | — | — | EP | claimed |
| WO-2007128983-A1 | PERSONAL CARE ARTICLE | RECKITT BENCKISER (UK) LIMITED (GB) | 2007-11-15 | — | — | WO | claimed |
| CN-100335037-C | Free-flowing powder composition comprising alpha-lipoic acid (derivatives) | DEGUSSA (DE) | 2007-09-05 | — | — | CN | claimed |
| CN-1662222-A | Free-flowing powder composition comprising alpha-lipoic acid (derivatives) | DEGUSSA (DE) | 2005-08-31 | — | — | CN | claimed |
| EP-1001735-B1 | DEPILATORY COMPOSITIONS, METHODS FOR THEIR PREPARATION AND THEIR USE | RECKITT BENCKISER FRANCE (FR) | 2003-03-19 | — | — | EP | claimed |
| US-6306380-B1 | FOR REMOVING UNWANTED BODY HAIR | RECKITT & COLMAN FRANCE (FR) | 2001-10-23 | — | — | US | claimed |
| EP-1001735-A1 | DEPILATORY COMPOSITIONS, METHODS FOR THEIR PREPARATION AND THEIR USE | Reckitt & Colman France (FR) | 2000-05-24 | — | — | EP | claimed |
| WO-1999002125-A1 | DEPILATORY COMPOSITIONS, METHODS FOR THEIR PREPARATION AND THEIR USE | RECKITT & COLMAN FRANCE (FR) | 1999-01-21 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080260671-A1 | Depilatory Compositions | TYR, NQO1, COMT | CA1 3338/4885CA2 4212/4885NFKB1 1035/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.