Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Dihydrolipoic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSTK1 | Q9Y2Q3 | 2/20 | 0.46 |
| ▸ | FOLH1 | Q04609 | 5/20 | 0.45 |
| ▸ | ENPEP | Q07075 | 4/20 | 0.44 |
| ▸ | ANPEP | P15144 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.37 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dihydrolipoic Acid SCHEMBL718014 | 0.93 | NFKB1 (0.43) | GSTK1FOLH1ENPEPNFKB1 | |
| Dihydrolipoic Acid SCHEMBL5827361 | 0.89 | NFKB1 (0.39) | GSTK1FOLH1ENPEPNFKB1 | |
| Dihydrolipoic Acid SCHEMBL2582100 | 0.89 | NFKB1 (0.39) | GSTK1FOLH1ENPEPNFKB1 | |
| Dihydrolipoic Acid SCHEMBL1659440 | 0.89 | NFKB1 (0.39) | GSTK1ENPEPNFKB1 | |
| Dihydrolipoic Acid SCHEMBL1115003 | 0.89 | FOLH1 (0.56) | GSTK1FOLH1ENPEPANPEPNFKB1 | |
| Dihydrolipoic Acid SCHEMBL19773 | 0.89 | FOLH1 (0.56) | GSTK1FOLH1ENPEPANPEPNFKB1 | |
| Dihydrolipoic Acid SCHEMBL618576 | 0.89 | FOLH1 (0.56) | GSTK1FOLH1ENPEPANPEPNFKB1 | |
| Dihydrolipoic Acid SCHEMBL867951 | 0.89 | FOLH1 (0.56) | GSTK1FOLH1ENPEPANPEPNFKB1 | |
| Dihydrolipoic Acid SCHEMBL4761909 | 0.87 | NFKB1 (0.38) | GSTK1FOLH1ENPEPNFKB1 | |
| SCHEMBL21611884 | 0.87 | GSTK1 (0.57) | GSTK1FOLH1ENPEPANPEPNFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9271913-B2 | Structured depilatory compositions | JOHNSON & JOHNSON CONSUMER INC. (US) | 2016-03-01 | — | — | US | disclosed |
| US-8623344-B2 | Structured depilatory compositions | MCNEIL-PPC, INC. (US) | 2014-01-07 | — | — | US | disclosed |
| EP-2011544-A2 | Structured Depilatory Compositions | McNeil-PPC, Inc. (US) | 2009-01-07 | — | — | EP | disclosed |
| US-20090005462-A1 | STRUCTURED DEPILATORY COMPOSITIONS | APPLIED OPTOELECTRONICS INC | 2009-01-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090005462-A1 | STRUCTURED DEPILATORY COMPOSITIONS | PSAP, HDAC6, MPO | GSTK1 992/4885FOLH1 2952/4885ENPEP 1929/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.