Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.59 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 2/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.42 |
| ▸ | BACE1 | P56817 | 2/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29509787 | 1.00 | AMY1A (0.59) | AMY1ATRPA1ALOX15HSD17B10ALDH1A1 | |
| SCHEMBL10440353 | 0.82 | TRPA1 (0.52) | AMY1ATRPA1ALOX15HSD17B10ALDH1A1 | |
| SCHEMBL29402131 | 0.81 | AMY1A (0.83) | AMY1ATRPA1ALOX15HSD17B10ALDH1A1 | |
| SCHEMBL29621432 | 0.81 | AMY1A (0.83) | AMY1ATRPA1ALOX15HSD17B10ALDH1A1 | |
| SCHEMBL9008165 | 0.81 | AMY1A (0.63) | AMY1ATRPA1ALOX15HSD17B10ALDH1A1 | |
| SCHEMBL50622 | 0.81 | AMY1A (0.83) | AMY1ATRPA1ALOX15HSD17B10ALDH1A1 | |
| SCHEMBL29395472 | 0.79 | AMY1A (0.61) | AMY1ATRPA1ALOX15HSD17B10ALDH1A1 | |
| SCHEMBL1023280 | 0.79 | AMY1A (0.61) | AMY1ATRPA1ALOX15HSD17B10ALDH1A1 | |
| SCHEMBL255991 | 0.79 | AMY1A (0.61) | AMY1ATRPA1ALOX15HSD17B10ALDH1A1 | |
| Methyl Alcohol SCHEMBL3081581 | 0.79 | AMY1A (0.80) | AMY1ATRPA1ALOX15HSD17B10ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 65 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3615015-B1 | GAMMA-KETOALDEHYDE SCAVENGERS FOR TREATING ATHEROSCLEROSIS | UNIV VANDERBILT (US) | 2024-03-13 | — | — | EP | claimed |
| US-20250214939-A1 | METHOD FOR TREATING INFLAMMATION AND HYPERTENSION WITH GAMMA-KETOALDEHYDE SKAVENGERS | VANDERBILT UNIVERSITY | 2025-07-03 | — | — | US | disclosed |
| US-20250034093-A1 | METHOD FOR TREATING LUPUS WITH GAMMA-KETOALDEHYDE SKAVENGERS | VANDERBILT UNIVERSITY | 2025-01-30 | — | — | US | disclosed |
| EP-3334464-B1 | MANGANESE-BASED CHELATE CONJUGATES FOR MOLECULAR MR IMAGING | MASSACHUSETTS GEN HOSPITAL (US) | 2024-04-10 | — | — | EP | disclosed |
| EP-2731597-B1 | METHODS FOR TREATING INFLAMMATION AND HYPERTENSION WITH GAMMA-KETOALDEHYDE SKAVENGERS | UNIV VANDERBILT (US) | 2023-12-20 | — | — | EP | disclosed |
| US-20230355549-A1 | METHOD OF PREVENTING KIDNEY INJURY DISRUPTION OF INTESTINAL LYMPHATICS | VANDERBILT UNIVERSITY | 2023-11-09 | — | — | US | disclosed |
| US-20230355549-A1 | METHOD OF PREVENTING KIDNEY INJURY DISRUPTION OF INTESTINAL LYMPHATICS | VANDERBILT UNIVERSITY | 2023-11-09 | — | — | US | disclosed |
| US-20230330049-A1 | COMPOSITIONS AND METHODS OF USE OF GAMMA-KETOALDHEYDE SCAVENGERS FOR TREATING, PREVENTING OR IMPROVING FIBROSIS OF THE LIVER | MTI BIOTECH, INC. | 2023-10-19 | — | — | US | disclosed |
| US-20230330049-A1 | COMPOSITIONS AND METHODS OF USE OF GAMMA-KETOALDHEYDE SCAVENGERS FOR TREATING, PREVENTING OR IMPROVING FIBROSIS OF THE LIVER | MTI BIOTECH, INC. | 2023-10-19 | — | — | US | disclosed |
| US-11696903-B2 | Compounds and methods for scavenging dicarbonyl electrophiles | VANDERBILT UNIVERSITY (US) | 2023-07-11 | — | — | US | disclosed |
| EP-1970375-A1 | ARYLMETHYLENE UREA DERIVATIVE AND USE THEREOF | TORAY INDUSTRIES, INC. (JP) | 2008-09-17 | — | — | EP | disclosed |
| EP-1970375-A1 | ARYLMETHYLENE UREA DERIVATIVE AND USE THEREOF | TORAY INDUSTRIES, INC. (JP) | 2008-09-17 | — | — | EP | disclosed |
| US-20070213407-A1 | Compounds to treat Alzheimer's disease | ELAN PHARMACEUTICALS AND PHARMACIA & UPJOHN COMPANY LLC | 2007-09-13 | — | — | US | disclosed |
| US-7214715-B2 | Compounds to treat Alzheimer's disease | PHARMACIA & UPJOHN (US) | 2007-05-08 | — | — | US | disclosed |
| US-20060106256-A1 | Substituted hydroxyethylamines | PHARMACIA & UPJOHN COMPANY | 2006-05-18 | — | — | US | disclosed |
| EP-1503980-A2 | SUBSTITUTED HYDROXYETHYLAMINES | Elan Pharmaceuticals, Inc. (US) | 2005-02-09 | — | — | EP | disclosed |
| EP-1353898-A2 | COMPOUNDS TO TREAT ALZHEIMER'S DISEASE | Elan Pharmaceuticals, Inc. (US) | 2003-10-22 | — | — | EP | disclosed |
| WO-2003072535-A2 | SUBSTITUTED HYDROXYETHYLAMINES | ELAN PHARMACEUTICALS, INC. (US) | 2003-09-04 | — | — | WO | disclosed |
| US-20020128255-A1 | Compounds to treat alzheimer's disease | PHARMACIA & UPJOHN COMPANY | 2002-09-12 | — | — | US | disclosed |
| WO-2002002512-A2 | COMPOUNDS TO TREAT ALZHEIMER'S DISEASE | ELAN PHARMACEUTICALS, INC. (US) | 2002-01-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020128255-A1 | Compounds to treat alzheimer's disease | PSEN2, PSEN1, APP | AMY1A 383/4885TRPA1 3165/4885ALOX15 1351/4885 |
| US-20070213407-A1 | Compounds to treat Alzheimer's disease | PSEN2, PSEN1, CHAT | AMY1A 1203/4885TRPA1 2601/4885ALOX15 1151/4885 |
| US-20250034093-A1 | METHOD FOR TREATING LUPUS WITH GAMMA-KETOALDEHYDE SKAVENGERS | SSB, GLO1, HMGCR | AMY1A 1963/4885TRPA1 4150/4885ALOX15 319/4885 |
| US-20250214939-A1 | METHOD FOR TREATING INFLAMMATION AND HYPERTENSION WITH GAMMA-KETOALDEHYDE SKAVENGERS | NFKBIA, PTGS1, HMGCR | AMY1A 1729/4885TRPA1 2382/4885ALOX15 204/4885 |
| US-20230355549-A1 | METHOD OF PREVENTING KIDNEY INJURY DISRUPTION OF INTESTINAL LYMPHATICS | FABP2, SI, MLN | AMY1A 2617/4885TRPA1 3226/4885ALOX15 621/4885 |
| US-20230330049-A1 | COMPOSITIONS AND METHODS OF USE OF GAMMA-KETOALDHEYDE SCAVENGERS FOR TREATING, PREVENTING OR IMPROVING FIBROSIS OF THE LIVER | GGT1, GGH, AKR7A2 | AMY1A 452/4885TRPA1 4358/4885ALOX15 510/4885 |
| US-20060106256-A1 | Substituted hydroxyethylamines | HNMT, PNMT, BCHE | AMY1A 2198/4885TRPA1 4445/4885ALOX15 2901/4885 |
| US-11696903-B2 | Compounds and methods for scavenging dicarbonyl electrophiles | OGG1, LGMN, GLO1 | AMY1A 1500/4885TRPA1 1725/4885ALOX15 462/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.