SCHEMBL786516

SCHEMBL786516

Nc1ccc(I)cc1C(F)(F)F

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
FFAR4 Q5NUL3 11/20 0.40
GLA P06280 1/20 0.40
POLB P06746 1/20 0.40
GAA P10253 1/20 0.40
TSHR P16473 1/20 0.40
FFAR1 O14842 3/20 0.38
SMN1; SMN2 Q16637 1/20 0.37
AR P10275 1/20 0.36
CFTR P13569 1/20 0.35
KIF11 P52732 1/20 0.34
CA12 O43570 1/20 0.34
CA1 P00915 1/20 0.34
CA2 P00918 1/20 0.34
CA4 P22748 1/20 0.34
CA6 P23280 1/20 0.34
CA5A P35218 1/20 0.34
CA7 P43166 1/20 0.34
CA9 Q16790 1/20 0.34
CA14 Q9ULX7 1/20 0.34
CA5B Q9Y2D0 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29354776 1.00 FFAR4 (0.40) FFAR4GLAPOLBGAATSHR
SCHEMBL29616267 0.82 KIF11 (0.41) FFAR4GLAPOLBGAATSHR
SCHEMBL1555044 0.78 NOTUM (0.37) GLAPOLBGAATSHRKIF11
SCHEMBL482274 0.77 ALDH1A1 (0.33) FFAR4GAATSHRFFAR1SMN1; SMN2
SCHEMBL29402330 0.76 GAA (0.67) FFAR4GLAPOLBGAATSHR
SCHEMBL3534403 0.76 GLA (0.54) GLAPOLBGAATSHRAR
SCHEMBL29403371 0.76 KIF11 (0.50) FFAR4GLAPOLBGAATSHR
SCHEMBL670777 0.76 GAA (0.67) FFAR4GLAPOLBGAATSHR
SCHEMBL349356 0.76 KIF11 (0.50) FFAR4GLAPOLBGAATSHR
SCHEMBL6058773 0.76 NOTUM (0.35) GLAPOLBGAATSHRCFTR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 39 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11603350-B2 Compound, composition, cured object, optically anisotropic body, and reflective film FUJIFILM CORPORATION (JP) 2023-03-14 US disclosed
US-11555026-B2 AHR inhibitors and uses thereof Ikena Oncology, Inc. (US) 2023-01-17 US disclosed
EP-3481819-B1 COMPOUNDS AND THEIR USE FOR REDUCING URIC ACID LEVELS ACQUIST LLC (US) 2022-06-01 EP disclosed
US-20210236495-A1 Compounds and Their Use for Reducing Uric Acid Levels ACQUIST LLC (US) 2021-08-05 US disclosed
US-11020397-B2 Compounds and their use for reducing uric acid levels ACQUIST LLC (US) 2021-06-01 US disclosed
US-20210040326-A1 AZACYANINE DYES AND USE THEREOF ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL) (CH) 2021-02-11 US disclosed
US-10907099-B2 Compound, composition, cured object, optically anisotropic body, and reflective film FUJIFILM CORPORATION (JP) 2021-02-02 US disclosed
US-10907099-B2 Compound, composition, cured object, optically anisotropic body, and reflective film FUJIFILM CORPORATION (JP) 2021-02-02 US disclosed
US-20210017153-A1 AHR INHIBITORS AND USES THEREOF PAHR THERAPEUTICS, INC. 2021-01-21 US disclosed
US-20210017153-A1 AHR INHIBITORS AND USES THEREOF PAHR THERAPEUTICS, INC. 2021-01-21 US disclosed
WO-2015154725-A1 QUINAZOLINE DERIVATIVE AND PREPARATION METHOD AND USE IN MEDICINE THEREOF 四川海思科制药有限公司 2015-10-15 WO disclosed
EP-1861357-B1 NOVEL COMPOUNDS OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF AS VANILLOID RECEPTOR ANTAGONIST; AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME AMOREPACIFIC CORP (KR) 2013-04-24 EP disclosed
WO-2012037108-A1 AMINOQUINOLINE DERIVATIVES AS ANTIVIRAL AGENTS GLAXOSMITHKLINE LLC (US) 2012-03-22 WO disclosed
WO-2012037108-A1 AMINOQUINOLINE DERIVATIVES AS ANTIVIRAL AGENTS GLAXOSMITHKLINE LLC (US) 2012-03-22 WO disclosed
US-7763657-B2 Compounds, isomer thereof, or pharmaceutically acceptable salts thereof as vanilloid receptor antagonist; and pharmaceutical compositions containing the same AMOREPACIFIC CORPORATION (KR) 2010-07-27 US disclosed
US-20090105258-A1 NOVEL COMPOUNDS, ISOMER THEREOF, OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF AS VANILLOID RECEPTOR ANTAGONIST; AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME AMOREPACIFIC CORPORATION (KR) 2009-04-23 US disclosed
WO-2007142426-A1 NOVEL COMPOUNDS, ISOMER THEREOF OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF AS VANILLOID RECEPTOR ANTAGONIST; AND A PHARMACEUTICAL COMPOSITION CONTAINING THE SAME AMOREPACIFIC CORPORATION (KR) 2007-12-13 WO disclosed
EP-1862454-A1 Novel compounds, isomer thereof or pharmaceutically acceptable salts thereof as vanilloid receptor antagonist; and a pharmaceutical composition containing the same Amorepacific Corporation (KR) 2007-12-05 EP disclosed
EP-1861357-A1 NOVEL COMPOUNDS, ISOMER THEREOF, OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF AS VANILLOID RECEPTOR ANTAGONIST; AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME Amorepacific Corporation (KR) 2007-12-05 EP disclosed
WO-2006101318-A1 NOVEL COMPOUNDS, ISOMER THEREOF, OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF AS VANILLOID RECEPTOR ANTAGONIST; AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME AMOREPACIFIC CORPORATION (KR) 2006-09-28 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11555026-B2 AHR inhibitors and uses thereof AHR, ARNT, AIPL1 FFAR4 814/4885GLA 3423/4885POLB 3508/4885
US-20210017153-A1 AHR INHIBITORS AND USES THEREOF AHR, ARNT, AIPL1 FFAR4 814/4885GLA 3423/4885POLB 3508/4885
US-20090105258-A1 NOVEL COMPOUNDS, ISOMER THEREOF, OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF AS VANILLOID RECEPTOR ANTAGONIST; AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME TRPV1, TRPA1, VIPR1 FFAR4 202/4885GLA 4290/4885POLB 4833/4885
US-10907099-B2 Compound, composition, cured object, optically anisotropic body, and reflective film CFL1, ADCY10, ADCY1 FFAR4 66/4885GLA 3379/4885POLB 4265/4885
US-20210040326-A1 AZACYANINE DYES AND USE THEREOF INMT, AZI2, MYADM FFAR4 2664/4885GLA 1975/4885POLB 4325/4885
US-20210236495-A1 Compounds and Their Use for Reducing Uric Acid Levels XDH, OAT, URB2 FFAR4 1875/4885GLA 657/4885POLB 1802/4885
US-11020397-B2 Compounds and their use for reducing uric acid levels XDH, OAT, UGT2B7 FFAR4 702/4885GLA 1414/4885POLB 1797/4885
US-11603350-B2 Compound, composition, cured object, optically anisotropic body, and reflective film FLNA, CFL1, MKI67 FFAR4 611/4885GLA 3203/4885POLB 3314/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.