Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 14/20 | 0.85 |
| ▸ | HTR2A | P28223 | 13/20 | 0.85 |
| ▸ | HTR2C | P28335 | 3/20 | 0.84 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.84 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.84 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.84 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.84 |
| ▸ | DRD1 | P21728 | 2/20 | 0.84 |
| ▸ | DRD4 | P21917 | 2/20 | 0.84 |
| ▸ | DRD5 | P21918 | 2/20 | 0.84 |
| ▸ | HTR1D | P28221 | 2/20 | 0.84 |
| ▸ | HTR1B | P28222 | 2/20 | 0.84 |
| ▸ | HTR7 | P34969 | 2/20 | 0.84 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.84 |
| ▸ | HRH1 | P35367 | 2/20 | 0.84 |
| ▸ | DRD3 | P35462 | 2/20 | 0.84 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.84 |
| ▸ | KCND3 | Q9UK17 | 1/20 | 0.84 |
| ▸ | HTR1A | P08908 | 4/20 | 0.76 |
| ▸ | ACHE | P22303 | 3/20 | 0.76 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Paliperidone SCHEMBL67205 | 0.91 | DRD2 (1.00) | DRD2HTR2AHTR2CKCNH2ADRA2A | |
| Paliperidone SCHEMBL20572022 | 0.91 | DRD2 (1.00) | DRD2HTR2AHTR2CKCNH2ADRA2A | |
| Paliperidone SCHEMBL29377584 | 0.91 | DRD2 (1.00) | DRD2HTR2AHTR2CKCNH2ADRA2A | |
| Paliperidone SCHEMBL436689 | 0.91 | DRD2 (1.00) | DRD2HTR2AHTR2CKCNH2ADRA2A | |
| Paliperidone SCHEMBL11899798 | 0.91 | DRD2 (1.00) | DRD2HTR2AHTR2CKCNH2ADRA2A | |
| SCHEMBL17245287 | 0.91 | DRD2 (0.84) | DRD2HTR2AHTR2CKCNH2ADRA2A | |
| Paliperidone SCHEMBL29409219 | 0.91 | DRD2 (1.00) | DRD2HTR2AHTR2CKCNH2ADRA2A | |
| SCHEMBL22146698 | 0.91 | DRD2 (0.84) | DRD2HTR2AHTR2CKCNH2ADRA2A | |
| Paliperidone SCHEMBL1443676 | 0.91 | DRD2 (0.98) | DRD2HTR2AHTR2CKCNH2ADRA2A | |
| SCHEMBL21074591 | 0.91 | HTR2A (0.83) | DRD2HTR2AHTR2CKCNH2ADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11559482-B2 | Biodegradable polyethylene glycol based water-insoluble hydrogels | ASCENDIS PHARMA A/S (DE) | 2023-01-24 | — | — | US | disclosed |
| US-20180064713-A1 | Modulators of Androgen Synthesis | Tangent Reprofiling Limited (GB) | 2018-03-08 | — | — | US | disclosed |
| US-9808462-B2 | Modulators of androgen synthesis | Tangent Reprofiling Limited (GB) | 2017-11-07 | — | — | US | disclosed |
| US-20170189407-A1 | Modulators of Androgen Synthesis | Tangent Reprofiling Limited (GB) | 2017-07-06 | — | — | US | disclosed |
| US-20170165268-A1 | Modulators of Androgen Synthesis | Tangent Reprofiling Limited (GB) | 2017-06-15 | — | — | US | disclosed |
| US-9585887-B2 | Modulators of androgen synthesis | Tangent Reprofiling Limited (GB) | 2017-03-07 | — | — | US | disclosed |
| US-20120071493-A1 | SUBSTITUTED 8-SULFONYL-2,3,4,5-TETRAHYDRO-1H-GAMMA-CARBOLINES, LIGANDS AND PHARMACEUTICAL COMPOSITION; METHOD FOR THE PRODUCTION AND USE OF SAME | IVASHCHENKO ANDREY ALEXANDROVICH (RU) | 2012-03-22 | — | — | US | disclosed |
| US-20120071493-A1 | SUBSTITUTED 8-SULFONYL-2,3,4,5-TETRAHYDRO-1H-GAMMA-CARBOLINES, LIGANDS AND PHARMACEUTICAL COMPOSITION; METHOD FOR THE PRODUCTION AND USE OF SAME | IVASHCHENKO ANDREY ALEXANDROVICH (RU) | 2012-03-22 | — | — | US | disclosed |
| US-7977480-B2 | Synthesis of paliperidone | SYNTHON BV (NL) | 2011-07-12 | — | — | US | disclosed |
| US-20110136853-A1 | LIGAND WITH A BROAD SPECTRUM OF PHARMACOLOGICAL ACTIVITY, A PHARMACEUTICAL COMPOSITION, A MEDICINAL AGENT AND A METHOD OF TREATMENT | IVASCHENKO ANDREY ALEXANDROVICH | 2011-06-09 | — | — | US | disclosed |
| EP-2236511-A2 | LIGANDS OF ALPHA-ADRENOCEPTORS AND OF DOPAMINE, HISTAMINE, IMIDAZOLINE AND SEROTONIN RECEPTORS AND THE USE THEREOF | Alla Chem, LLC. (US) | 2010-10-06 | — | — | EP | disclosed |
| US-20100010218-A1 | SYNTHESIS OF PALIPERIDONE | SYNTHON BV (NL) | 2010-01-14 | — | — | US | disclosed |
| WO-2009082268-A2 | LIGANDS OF α-ADRENOCEPTORS AND OF DOPAMINE, HISTAMINE, IMIDAZOLINE AND SEROTONIN RECEPTORS AND THE USE THEREOF | ALLA CHEM, LLC (US) | 2009-07-02 | — | — | WO | disclosed |
| US-20090156810-A1 | SYNTHESIS OF PALIPERIDONE | SYNTHON BV (NL) | 2009-06-18 | — | — | US | disclosed |
| US-20090036470-A1 | PALIPERIDONE DERIVATIVES | SYNTHON BV (NL) | 2009-02-05 | — | — | US | disclosed |
| WO-2009016653-A1 | STABLE POLYMORPHIC FORM OF PALIPERIDONE AND PROCESS FOR ITS PREPARATION | NATCO PHARMA LIMITED (IN) | 2009-02-05 | — | — | WO | disclosed |
| US-20080214808-A1 | Preparation of Aseptic 3-[2-[4-((6-Fluoro-1,2-Benzisoxazol-3-Yl)-1-Piperidinyl]-6,7,8,9-Tetrahydro-9-Hydroxy-2-Methyl-4H-Pyrido[1,2-a]Pyrimidin-4-One Palmitate Ester | SPITTAELS THOMAS FREDERIK ERNESTINE | 2008-09-04 | — | — | US | disclosed |
| EP-0453042-B1 | Novel 2,9-disubstituted-4H-pyrido-[1,2-a]pyrimidin-4-ones | JANSSEN PHARMACEUTICA NV (BE) | 1999-11-03 | — | — | EP | disclosed |
| US-5482943-A | ANTIPSYCHOTIC AGENTS, DOPAMINE ANTAGONIST | JANSSEN PHARMACEUTICA N.V. (BE) | 1996-01-09 | — | — | US | disclosed |
| EP-0453042-A1 | Novel 2,9-disubstituted-4H-pyrido-[1,2-a]pyrimidin-4-ones | JANSSEN PHARMACEUTICA N.V. (BE) | 1991-10-23 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100010218-A1 | SYNTHESIS OF PALIPERIDONE | AVPR2, NPPA, GCG | DRD2 1126/4885HTR2A 890/4885HTR2C 1370/4885 |
| US-20110136853-A1 | LIGAND WITH A BROAD SPECTRUM OF PHARMACOLOGICAL ACTIVITY, A PHARMACEUTICAL COMPOSITION, A MEDICINAL AGENT AND A METHOD OF TREATMENT | CNR1, TRPV1, TRPM7 | DRD2 98/4885HTR2A 130/4885HTR2C 76/4885 |
| US-20180064713-A1 | Modulators of Androgen Synthesis | NR5A1, AR, CYP17A1 | DRD2 4195/4885HTR2A 1165/4885HTR2C 1291/4885 |
| US-20090156810-A1 | SYNTHESIS OF PALIPERIDONE | ACOX1, ALOX15B, ALOX15 | DRD2 1765/4885HTR2A 633/4885HTR2C 726/4885 |
| US-20090036470-A1 | PALIPERIDONE DERIVATIVES | NPY1R, NPY4R, GLP1R | DRD2 440/4885HTR2A 501/4885HTR2C 383/4885 |
| US-11559482-B2 | Biodegradable polyethylene glycol based water-insoluble hydrogels | PLG, PHYKPL, PLOD3 | DRD2 3619/4885HTR2A 4239/4885HTR2C 4218/4885 |
| US-20120071493-A1 | SUBSTITUTED 8-SULFONYL-2,3,4,5-TETRAHYDRO-1H-GAMMA-CARBOLINES, LIGANDS AND PHARMACEUTICAL COMPOSITION; METHOD FOR THE PRODUCTION AND USE OF SAME | SIGMAR1, ADRA2C, ADRB2 | DRD2 62/4885HTR2A 47/4885HTR2C 9/4885 |
| US-20170165268-A1 | Modulators of Androgen Synthesis | NR5A1, AR, CYP17A1 | DRD2 4195/4885HTR2A 1165/4885HTR2C 1291/4885 |
| US-20170189407-A1 | Modulators of Androgen Synthesis | NR5A1, AR, CYP17A1 | DRD2 4195/4885HTR2A 1165/4885HTR2C 1291/4885 |
| US-20080214808-A1 | Preparation of Aseptic 3-[2-[4-((6-Fluoro-1,2-Benzisoxazol-3-Yl)-1-Piperidinyl]-6,7,8,9-Tetrahydro-9-Hydroxy-2-Methyl-4H-Pyrido[1,2-a]Pyrimidin-4-One Palmitate Ester | CASP1, FFAR1, FFAR4 | DRD2 3643/4885HTR2A 1860/4885HTR2C 2619/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.