SCHEMBL836019

SCHEMBL836019

CNC(=O)CCN1C(=O)C=CC1=O

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PTGS1 P23219 7/20 0.47
PTGS2 P35354 7/20 0.47
MGLL Q99685 7/20 0.46
FAAH O00519 3/20 0.46
ALDH1A1 P00352 3/20 0.45
LMNA P02545 3/20 0.45
MAPT P10636 2/20 0.45
NPSR1 Q6W5P4 2/20 0.45
HPGD P15428 2/20 0.45
HSP90AA1 P07900 1/20 0.45
TLR9 Q9NR96 1/20 0.45
TP53 P04637 1/20 0.45
PKM P14618 1/20 0.45
XBP1 P17861 1/20 0.45
MAPK1 P28482 1/20 0.45
HTT P42858 1/20 0.45
RECQL P46063 1/20 0.45
RAB9A P51151 1/20 0.45
SMN1; SMN2 Q16637 1/20 0.45
GPR35 Q9HC97 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12581439 0.89 MGLL (0.54) PTGS1PTGS2MGLLFAAHALDH1A1
SCHEMBL22422923 0.88 PTGS1 (0.38) PTGS1PTGS2MGLLFAAHALDH1A1
SCHEMBL14571358 0.87 PTGS1 (0.41) PTGS1PTGS2MGLLFAAHALDH1A1
SCHEMBL19479888 0.87 PTGS1 (0.61) PTGS1PTGS2MGLLFAAHALDH1A1
SCHEMBL14395731 0.86 PTGS1 (0.37) PTGS1PTGS2MGLLFAAHALDH1A1
SCHEMBL27415275 0.86 PTGS1 (0.40) PTGS1PTGS2MGLLFAAHALDH1A1
SCHEMBL12146979 0.85 PTGS1 (0.64) PTGS1PTGS2MGLLFAAHALDH1A1
SCHEMBL3646852 0.85 PTGS1 (0.64) PTGS1PTGS2MGLLFAAHALDH1A1
SCHEMBL26584960 0.85 PTGS1 (0.44) PTGS1PTGS2MGLLFAAHALDH1A1
SCHEMBL12659454 0.84 NAMPT (0.47) PTGS1PTGS2MGLLFAAHALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 228 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024085190-A1 LIPID COMPOSITION AND METHOD OF DELIVERING THERAPEUTIC AGENT FUJIFILM CORPORATION (JP) 2024-04-25 WO disclosed
US-20230381337-A1 MIR-145 MICELLES FOR MITIGATING ATHEROSCLEROSIS NATIONAL INSTITUTES OF HEALTH 2023-11-30 US disclosed
WO-2023215740-A1 IMMUNOMODULATORY ANTIBODY-DRUG CONJUGATES SEAGEN INC. (US) 2023-11-09 WO disclosed
US-20230323028-A1 ADHESIVE PHOTOPROTECTIVE COMPOUNDS AND USES THEREOF SKINOSIVE (FR) 2023-10-12 US disclosed
US-20230265429-A1 SKELETAL MUSCLE DELIVERY PLATFORMS AND METHODS OF USE THEREOF Arrowhead Pharmaceuticals, Inc. 2023-08-24 US disclosed
US-20230256091-A1 ANTI-TUMOR NANO ADJUVANT BASED ON VESICLE FORMED BY CROSS-LINKED BIODEGRADABLE POLYMER, PREPARATION METHOD THEREFOR AND USE THEREOF SOOCHOW UNIVERSITY (CN) 2023-08-17 US disclosed
US-20230256091-A1 ANTI-TUMOR NANO ADJUVANT BASED ON VESICLE FORMED BY CROSS-LINKED BIODEGRADABLE POLYMER, PREPARATION METHOD THEREFOR AND USE THEREOF SOOCHOW UNIVERSITY (CN) 2023-08-17 US disclosed
US-20230158141-A1 Conjugates of Biomolecule and Use Thereof YAFEI SHANGHAI BIOLOG MEDICINE SCIENCE & TECHNOLOG (CN) 2023-05-25 US disclosed
US-20230131121-A1 BRANCHED DISCRETE PEG CONSTRUCTS AUDAX PRIVATE DEBT LLC, AS AGENT 2023-04-27 US disclosed
US-11634448-B2 Metabolic labeling and molecular enhancement of biological materials using bioorthogonal reactions THE GENERAL HOSPITAL CORPORATION (US) 2023-04-25 US disclosed
US-20080226657-A1 Antibody-drug conjugates; Auristatin peptides, including MeVal-Val-Dil-Dap-Norephedrine (MMAE) and MeVal-Val-Dil-Dap-Phe (MMAF); cancer; autoimmune diseases SEATTLE GENETICS, INC. (US) 2008-09-18 US disclosed
US-20080199483-A1 LONG LASTING FUSION PEPTIDE INHIBITORS OF VIRAL INFECTION CONJUCHEM BIOTECHNOLOGIES INC., (CA) 2008-08-21 US disclosed
US-20080176794-A1 LONG LASTING FUSION PEPTIDE INHIBITORS OF VIRAL INFECTION CONJUCHEM BIOTECHNOLOGIES INC. (CA) 2008-07-24 US disclosed
US-20080171040-A1 Maytansinoids linked to antibody which binds to ErbB receptor, or which binds tumor-associated antigens or cell-surface receptors GENENTECH, INC. (US) 2008-07-17 US disclosed
US-20080039532-A1 Compounds For Specific Viral Target ADVANCED DIAGNOSTICS AND DISCOVERY 2008-02-14 US disclosed
US-7307148-B2 Method for purification of albumin conjugates CONJUCHEM BIOTECHNOLOGIES INC. (CA) 2007-12-11 US disclosed
US-7307148-B2 Method for purification of albumin conjugates CONJUCHEM BIOTECHNOLOGIES INC. (CA) 2007-12-11 US disclosed
US-20070134243-A1 Antibody drug conjugates and methods GENENTECH, INC. 2007-06-14 US disclosed
US-20070117153-A1 Molecular conjugate VENTANA MEDICAL SYSTEMS, INC. 2007-05-24 US disclosed
US-20070092940-A1 A free cysteine amino acid is a cysteine residue which has been engineered into the parent antibody and is not part of a disulfide bridge; diagnostics and therapeutics; killing or inhibiting the proliferation of tumor cells or cancer cells GENENTECH, INC. (US) 2007-04-26 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (15 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11634448-B2 Metabolic labeling and molecular enhancement of biological materials using bioorthogonal reactions GALNT14, NEU4, CSGALNACT1 PTGS1 2107/4885PTGS2 2044/4885MGLL 830/4885
US-20230323028-A1 ADHESIVE PHOTOPROTECTIVE COMPOUNDS AND USES THEREOF ICAM1, CDH1, VCAM1 PTGS1 1018/4885PTGS2 1388/4885MGLL 3691/4885
US-20230256091-A1 ANTI-TUMOR NANO ADJUVANT BASED ON VESICLE FORMED BY CROSS-LINKED BIODEGRADABLE POLYMER, PREPARATION METHOD THEREFOR AND USE THEREOF GOT1, WEE1, HADH PTGS1 784/4885PTGS2 1183/4885MGLL 2996/4885
US-20230131121-A1 BRANCHED DISCRETE PEG CONSTRUCTS BTD, IDUA, DNPEP PTGS1 606/4885PTGS2 734/4885MGLL 147/4885
US-20230381337-A1 MIR-145 MICELLES FOR MITIGATING ATHEROSCLEROSIS TGFB1, SENP5, SENP1 PTGS1 2566/4885PTGS2 3401/4885MGLL 1054/4885
US-20230158141-A1 Conjugates of Biomolecule and Use Thereof CD47, FCGR2A, CD40 PTGS1 1461/4885PTGS2 1646/4885MGLL 2474/4885
US-20080199483-A1 LONG LASTING FUSION PEPTIDE INHIBITORS OF VIRAL INFECTION DNPEP, HM13, PELP1 PTGS1 3139/4885PTGS2 3944/4885MGLL 3031/4885
US-20080039532-A1 Compounds For Specific Viral Target HAVCR2, CNBP, SRRM2 PTGS1 3148/4885PTGS2 3273/4885MGLL 4591/4885
US-20080226657-A1 Antibody-drug conjugates; Auristatin peptides, including MeVal-Val-Dil-Dap-Norephedrine (MMAE) and MeVal-Val-Dil-Dap-Phe (MMAF); cancer; autoimmune diseases MMAB, CAD, VIM PTGS1 4626/4885PTGS2 4832/4885MGLL 4677/4885
US-20070134243-A1 Antibody drug conjugates and methods BOD1L1, MKI67, CCNI PTGS1 1967/4885PTGS2 1927/4885MGLL 4187/4885
US-20080171040-A1 Maytansinoids linked to antibody which binds to ErbB receptor, or which binds tumor-associated antigens or cell-surface receptors ERBB2, EGFR, ERBB4 PTGS1 2456/4885PTGS2 3386/4885MGLL 3202/4885
US-20230265429-A1 SKELETAL MUSCLE DELIVERY PLATFORMS AND METHODS OF USE THEREOF MUSK, MYLK2, TNNC1 PTGS1 4352/4885PTGS2 4342/4885MGLL 3971/4885
US-20080176794-A1 LONG LASTING FUSION PEPTIDE INHIBITORS OF VIRAL INFECTION DNPEP, HM13, PELP1 PTGS1 3139/4885PTGS2 3944/4885MGLL 3031/4885
US-20070092940-A1 A free cysteine amino acid is a cysteine residue which has been engineered into the parent antibody and is not part of a disulfide bridge; diagnostics and therapeutics; killing or inhibiting the proliferation of tumor cells or cancer cells LNPEP, CSTB, ALB PTGS1 1595/4885PTGS2 2320/4885MGLL 2872/4885
US-20070117153-A1 Molecular conjugate CA12, FCGR2A, CA14 PTGS1 2352/4885PTGS2 1788/4885MGLL 3988/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.