SCHEMBL8416378

SCHEMBL8416378

C=CC(=O)OCCOC(=O)C(O)CC(=O)O

nearest known ligand 0.53

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
TSHR P16473 7/20 0.53
ALDH1A1 P00352 4/20 0.53
TP53 P04637 3/20 0.53
HIF1A Q16665 3/20 0.53
HSD17B10 Q99714 1/20 0.53
CYP3A4 P08684 2/20 0.48
THRB P10828 2/20 0.45
HPGD P15428 1/20 0.44
SMN1; SMN2 Q16637 2/20 0.40
MAPK1 P28482 1/20 0.36
SLC22A6 Q4U2R8 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL261228 0.85 TSHR (0.53) TSHRALDH1A1TP53HIF1AHSD17B10
Hydroxyl Radical SCHEMBL28232486 0.84 TSHR (0.52) TSHRALDH1A1TP53HIF1AHSD17B10
SCHEMBL1201601 0.81 SMN1; SMN2 (0.43) TSHRALDH1A1TP53HIF1AHSD17B10
Malic Acid SCHEMBL261227 0.81 TSHR (0.63) TSHRALDH1A1TP53HIF1AHSD17B10
SCHEMBL811744 0.80 TSHR (0.52) TSHRALDH1A1TP53HIF1AHSD17B10
SCHEMBL260837 0.79 TSHR (0.55) TSHRALDH1A1TP53HIF1AHSD17B10
Malic Acid SCHEMBL260836 0.78 TSHR (0.50) TSHRALDH1A1TP53HIF1AHSD17B10
SCHEMBL5144706 0.77 TSHR (0.49) TSHRALDH1A1TP53HIF1AHSD17B10
SCHEMBL17736524 0.77 TSHR (0.48) TSHRALDH1A1TP53HIF1AHSD17B10
SCHEMBL30604742 0.77 TSHR (0.84) TSHRALDH1A1TP53HIF1AHSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 81 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4725470-A1 CURABLE DENTAL COMPOSITION Kuraray Noritake Dental Inc. (JP) 2026-04-15 EP disclosed
EP-4717249-A1 DENTAL COMPOSITION Shofu Inc. (JP) 2026-04-01 EP disclosed
US-20260083644-A1 METHOD FOR PRODUCING DENTAL POLYMERIZABLE COMPOSITION OR DENTAL POLYMERIZABLE COMPOSITION INTERMEDIATE SHOFU INC (JP) 2026-03-26 US disclosed
US-20260083642-A1 DENTAL COMPOSITION SHOFU INC (JP) 2026-03-26 US disclosed
US-12564543-B2 Dental composition KURARAY NORITAKE DENTAL INC. (JP) 2026-03-03 US disclosed
US-12527725-B2 Solvent-free dental adhesive composition KURARAY NORITAKE DENTAL INC. (JP) 2026-01-20 US disclosed
US-20250381101-A1 HIGHLY FLOWABLE DENTAL CURABLE COMPOSITION SHOFU INC. (JP) 2025-12-18 US disclosed
EP-4649938-A1 DENTAL COMPOSITION Kuraray Noritake Dental Inc. (JP) 2025-11-19 EP disclosed
US-12377026-B2 Dental adhesive material kit KURARAY NORITAKE DENTAL INC. (JP) 2025-08-05 US disclosed
US-20250223282-A1 ASCORBIC ACID DERIVATIVE OR SALT THEREOF, ADDITIVE FOR POLYMERIZATION INITIATION, POLYMERIZATION INITIATOR, CURABLE COMPOSITION PREPARATION KIT, CURABLE COMPOSITION, CURED PRODUCT, AND DENTAL MATERIAL MITSUI CHEMICALS, INC. (JP) 2025-07-10 US disclosed
EP-4043002-A1 DENTAL COMPOSITION Kuraray Noritake Dental Inc. (JP) 2022-08-17 EP disclosed
US-11400030-B2 Two-paste dental curable composition KURARAY NORITAKE DENTAL INC. (JP) 2022-08-02 US disclosed
US-20220175621-A1 SOLVENT-FREE DENTAL ADHESIVE COMPOSITION KURARAY NORITAKE DENTAL INC. (JP) 2022-06-09 US disclosed
EP-2873410-B1 DENTAL ADHESIVE COMPOSITION TOKUYAMA DENTAL CORP (JP) 2022-05-04 EP disclosed
US-11304879-B2 Adhesive composition for dental use KURARAY NORITAKE DENTAL INC. (JP) 2022-04-19 US disclosed
US-20220071852-A1 ADHESIVE COMPOSITION FOR DENTAL USE KURARAY NORITAKE DENTAL INC. (JP) 2022-03-10 US disclosed
WO-2022030642-A1 COMPOSITION FOR DENTAL ATTACHMENT クラレノリタケデンタル株式会社 2022-02-10 WO disclosed
EP-0712622-B1 Dental composition and kit TOKUYAMA CORP (JP) 1999-09-01 EP disclosed
US-5925690-A UNSATURATED PHOSPHATE AND UNSATURATED POLYCARBOXYLIC ACID MONOMERS; BONDING AND TENSILE STRENGTH TO DENTIN AND ENAMEL TOKUYAMA CORPROATION (JP) 1999-07-20 US disclosed
EP-0712622-A1 Dental composition and kit TOKUYAMA CORPORATION (JP) 1996-05-22 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250223282-A1 ASCORBIC ACID DERIVATIVE OR SALT THEREOF, ADDITIVE FOR POLYMERIZATION INITIATION, POLYMERIZATION INITIATOR, CURABLE COMPOSITION PREPARATION KIT, CURABLE COMPOSITION, CURED PRODUCT, AND DENTAL MATERIAL PROC, THEM6, RBCK1 TSHR 4865/4885ALDH1A1 335/4885TP53 3719/4885
US-20220175621-A1 SOLVENT-FREE DENTAL ADHESIVE COMPOSITION CDH1, ICAM1, ITGA1 TSHR 4862/4885ALDH1A1 666/4885TP53 2287/4885
US-20260083644-A1 METHOD FOR PRODUCING DENTAL POLYMERIZABLE COMPOSITION OR DENTAL POLYMERIZABLE COMPOSITION INTERMEDIATE ARCN1, LBR, POLL TSHR 3634/4885ALDH1A1 2312/4885TP53 1209/4885
US-12527725-B2 Solvent-free dental adhesive composition CDH1, ITGA1, ITGB8 TSHR 3896/4885ALDH1A1 1885/4885TP53 3320/4885
US-11304879-B2 Adhesive composition for dental use PTK2, CDH1, ITGA1 TSHR 4724/4885ALDH1A1 148/4885TP53 3432/4885
US-20250381101-A1 HIGHLY FLOWABLE DENTAL CURABLE COMPOSITION RCC1, H1-0, H1-3 TSHR 2062/4885ALDH1A1 1031/4885TP53 1290/4885
US-12564543-B2 Dental composition CAD, ARCN1, MAT1A TSHR 4074/4885ALDH1A1 306/4885TP53 1778/4885
US-20220071852-A1 ADHESIVE COMPOSITION FOR DENTAL USE CDH1, CAD, DIAPH1 TSHR 4854/4885ALDH1A1 1273/4885TP53 1532/4885
US-11400030-B2 Two-paste dental curable composition CAD, DNMT3A, DNMT3B TSHR 4487/4885ALDH1A1 1331/4885TP53 1879/4885
US-20260083642-A1 DENTAL COMPOSITION TAS2R42, COL2A1, TAS2R1 TSHR 1588/4885ALDH1A1 1319/4885TP53 1688/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.