SCHEMBL8437822

SCHEMBL8437822

C=C(C)C(=O)Nc1ccc(OC(C)=O)c(C(=O)[O-])c1.[Na+]

nearest known ligand 0.47

Known targets — ChEMBL curated mechanism

ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PTGS1 known ✓ P23219 1/20 0.36
PTGS2 known ✓ P35354 1/20 0.36
TDP1 Q9NUW8 3/20 0.47
POLB P06746 2/20 0.47
L3MBTL1 Q9Y468 2/20 0.47
BLM P54132 2/20 0.45
RECQL P46063 1/20 0.45
RXFP1 Q9HBX9 1/20 0.43
CFD P00746 2/20 0.41
TOP1 P11387 4/20 0.41
BAZ1A Q9NRL2 1/20 0.39
ALDH1A1 P00352 3/20 0.39
NR1H4 Q96RI1 1/20 0.39
EGFR P00533 1/20 0.38
ERBB2 P04626 1/20 0.38
PKM P14618 2/20 0.38
NPC1 O15118 1/20 0.38
RAB9A P51151 1/20 0.38
SMN1; SMN2 Q16637 1/20 0.38
KDM4E B2RXH2 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8436420 0.87 CFD (0.56) TDP1POLBL3MBTL1BLMRECQL
SCHEMBL8440505 0.86 TDP1 (0.47) TDP1POLBL3MBTL1BLMRECQL
SCHEMBL8437783 0.86 TDP1 (0.47) TDP1POLBL3MBTL1BLMRECQL
SCHEMBL8438097 0.81 MAPT (0.45) TDP1POLBL3MBTL1BLMRECQL
SCHEMBL2350573 0.79 KDM4E (0.55) TDP1POLBL3MBTL1BLMRECQL
SCHEMBL2345862 0.78 TDP1 (0.49) TDP1POLBL3MBTL1BLMRECQL
SCHEMBL6535486 0.78 TDP1 (0.52) TDP1POLBL3MBTL1BLMRECQL
SCHEMBL8437875 0.75 EGFR (0.40) TDP1POLBL3MBTL1BLMRECQL
SCHEMBL179011 0.74 TOP1 (0.58) TOP1ALDH1A1PKMNPC1RAB9A
SCHEMBL28190954 0.73 IMPDH2 (0.63) TDP1POLBL3MBTL1ALDH1A1NPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0732322-B1 Acetylsalicylic acid derivatives having a vinyl group UBE INDUSTRIES (JP) 1999-12-22 EP disclosed
US-5693320-A ANTICOAGULANTS, BIOCOMPATIBILITY, MEDICAL EQUIPMENT UBE INDUSTRIES, LTD. (JP) 1997-12-02 US disclosed
EP-0732322-A1 Acetylsalicylic acid derivatives having a vinyl group UBE INDUSTRIES, LTD. (JP) 1996-09-18 EP disclosed