Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DNMT1 | P26358 | 6/20 | 0.63 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.63 |
| ▸ | TK1 | P04183 | 2/20 | 0.60 |
| ▸ | DNMT3B | Q9UBC3 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | PNP | P00491 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.49 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.49 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.49 |
| ▸ | FPR2 | P25090 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | BLM | P54132 | 1/20 | 0.47 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ibacitabine SCHEMBL5981937 | 1.00 | DNMT1 (0.63) | DNMT1ADRB1TK1DNMT3BLMNA | |
| Ibacitabine SCHEMBL21423094 | 1.00 | DNMT1 (0.63) | DNMT1ADRB1TK1DNMT3BLMNA | |
| Ibacitabine SCHEMBL225403 | 1.00 | DNMT1 (0.63) | DNMT1ADRB1TK1DNMT3BLMNA | |
| Ibacitabine SCHEMBL5981939 | 1.00 | DNMT1 (0.63) | DNMT1ADRB1TK1DNMT3BLMNA | |
| Ibacitabine SCHEMBL13812993 | 1.00 | DNMT1 (0.63) | DNMT1ADRB1TK1DNMT3BLMNA | |
| Ibacitabine SCHEMBL225402 | 1.00 | DNMT1 (0.63) | DNMT1ADRB1TK1DNMT3BLMNA | |
| Ibacitabine SCHEMBL244921 | 1.00 | DNMT1 (0.63) | DNMT1ADRB1TK1DNMT3BLMNA | |
| SCHEMBL1635378 | 0.91 | DNMT1 (0.52) | DNMT1ADRB1TK1DNMT3BFPR2 | |
| SCHEMBL1635376 | 0.91 | DNMT1 (0.52) | DNMT1ADRB1TK1DNMT3BFPR2 | |
| Ibacitabine SCHEMBL9710365 | 0.91 | DNMT1 (0.54) | DNMT1ADRB1TK1DNMT3BLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 46 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230203083-A1 | NUCLEOTIDE ANALOGUES | FIRST-CITIZENS BANK & TRUST COMPANY | 2023-06-29 | — | — | US | disclosed |
| US-11649451-B2 | Evolution of bioactive sequence-defined synthetic polymers using DNA-templated polymerization | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2023-05-16 | — | — | US | disclosed |
| US-11649451-B2 | Evolution of bioactive sequence-defined synthetic polymers using DNA-templated polymerization | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2023-05-16 | — | — | US | disclosed |
| US-11085076-B2 | Synthesis of novel disulfide linker based nucleotides as reversible terminators for DNA sequencing by synthesis | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2021-08-10 | — | — | US | disclosed |
| US-20200172896-A1 | EVOLUTION OF BIOACTIVE SEQUENCE-DEFINED SYNTHETIC POLYMERS USING DNA-TEMPLATED POLYMERIZATION | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2020-06-04 | — | — | US | disclosed |
| US-10669538-B2 | Templated molecules and methods for using such molecules | NUEVOLUTION A/S (DK) | 2020-06-02 | — | — | US | disclosed |
| WO-2019227526-A1 | FLUORESCENTLY LABELLED NUCLEOTIDE AND PREPARATION METHOD AND USE THEREOF | 苏州百源基因技术有限公司 (CN) | 2019-12-05 | — | — | WO | disclosed |
| WO-2019010441-A1 | EVOLUTION BIOACTIVE SEQUENCE-DEFINED SYNTHETIC POLYMERS USING DNA-TEMPLATED POLYMERIZATION | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2019-01-10 | — | — | WO | disclosed |
| WO-2018143893-A1 | IDOXURIDINE AND ITS ANALOGS AS NEUROPROTECTANS FOR THE TREATMENT OF PARKINSONISM | SVENNINGSSON PER (SE) | 2018-08-09 | — | — | WO | disclosed |
| US-10000801-B2 | Four-color DNA sequencing by synthesis using cleavable fluorescent nucleotide reversible terminators | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2018-06-19 | — | — | US | disclosed |
| US-8193335-B2 | Click chemistry for the production of reporter molecules | BASECLICK GMBH (DE) | 2012-06-05 | — | — | US | disclosed |
| US-8105770-B2 | Method of detecting amplification or deletion in genomic DNA Fragment | WAKO PURE CHEMICAL INDUSTRIES, LTD. (JP) | 2012-01-31 | — | — | US | disclosed |
| US-7883869-B2 | for sequencing single-stranded DNA by employing a nanopore and modified nucleotides | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2011-02-08 | — | — | US | disclosed |
| US-7727713-B2 | Templated molecules and methods for using such molecules | NUEVOLUTION A/S (DK) | 2010-06-01 | — | — | US | disclosed |
| US-7727713-B2 | Templated molecules and methods for using such molecules | NUEVOLUTION A/S (DK) | 2010-06-01 | — | — | US | disclosed |
| US-20100112711-A1 | METHOD OF DETECTING AMPLIFICATION OR DELETION IN GENOMIC DNA FRAGMENT | WAKO PURE CHEMICAL INDUSTRIES, LTD. (JP) | 2010-05-06 | — | — | US | disclosed |
| US-20100092952-A1 | FOUR-COLOR DNA SEQUENCING BY SYNTHESIS USING CLEAVABLE FLUORESCENT NUCLEOTIDE REVERSIBLE TERMINATORS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2010-04-15 | — | — | US | disclosed |
| US-20100081137-A1 | Click Chemistry for the Production of Reporter Molecules | BASECLICK GMBH (DE) | 2010-04-01 | — | — | US | disclosed |
| US-20100016177-A1 | TEMPLATED MOLECULES AND METHODS FOR USING SUCH MOLECULES | NUEVOLUTION A/S (DK) | 2010-01-21 | — | — | US | disclosed |
| US-20090069546-A1 | PYRAZOLE-BASED CYANINE DYE | WAKO PURE CHEMICAL INDUSTRIES, LTD. (JP) | 2009-03-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090069546-A1 | PYRAZOLE-BASED CYANINE DYE | CBR3, CYB5R3, TST | DNMT1 3683/4885ADRB1 1209/4885TK1 3542/4885 |
| US-20100112711-A1 | METHOD OF DETECTING AMPLIFICATION OR DELETION IN GENOMIC DNA FRAGMENT | GLB1, GDA, DNTT | DNMT1 199/4885ADRB1 4446/4885TK1 7/4885 |
| US-20200172896-A1 | EVOLUTION OF BIOACTIVE SEQUENCE-DEFINED SYNTHETIC POLYMERS USING DNA-TEMPLATED POLYMERIZATION | PCSK9, IL6, PCSK6 | DNMT1 473/4885ADRB1 4715/4885TK1 1078/4885 |
| US-20100016177-A1 | TEMPLATED MOLECULES AND METHODS FOR USING SUCH MOLECULES | INTS6, ABL1, INMT | DNMT1 319/4885ADRB1 4209/4885TK1 772/4885 |
| US-20100081137-A1 | Click Chemistry for the Production of Reporter Molecules | DNTT, RNGTT, NSUN3 | DNMT1 552/4885ADRB1 4572/4885TK1 313/4885 |
| US-11085076-B2 | Synthesis of novel disulfide linker based nucleotides as reversible terminators for DNA sequencing by synthesis | POLRMT, RNGTT, MTR | DNMT1 86/4885ADRB1 4821/4885TK1 78/4885 |
| US-11649451-B2 | Evolution of bioactive sequence-defined synthetic polymers using DNA-templated polymerization | PCSK9, IL6, PCSK6 | DNMT1 473/4885ADRB1 4715/4885TK1 1078/4885 |
| US-10669538-B2 | Templated molecules and methods for using such molecules | ABL1, DHFR, TYMS | DNMT1 551/4885ADRB1 4795/4885TK1 503/4885 |
| US-20230203083-A1 | NUCLEOTIDE ANALOGUES | ITPA, POLB, NUDT1 | DNMT1 303/4885ADRB1 3502/4885TK1 98/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.