Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ANPEP | P15144 | 1/20 | 0.47 |
| ▸ | ENPEP | Q07075 | 1/20 | 0.47 |
| ▸ | SLC6A1 | P30531 | 2/20 | 0.41 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.41 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.41 |
| ▸ | SLC6A12 | P48065 | 2/20 | 0.41 |
| ▸ | SLC6A11 | P48066 | 2/20 | 0.41 |
| ▸ | SLC6A13 | Q9NSD5 | 2/20 | 0.41 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.41 |
| ▸ | GABRR1 | P24046 | 1/20 | 0.41 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.41 |
| ▸ | SLC1A2 | P43004 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10232799 | 1.00 | ANPEP (0.47) | ANPEPENPEPSLC6A1GABRA5GABRB2 | |
| SCHEMBL939910 | 1.00 | ANPEP (0.47) | ANPEPENPEPSLC6A1GABRA5GABRB2 | |
| SCHEMBL13910150 | 0.88 | ANPEP (0.41) | ANPEPENPEPSLC6A1GABRA5GABRB2 | |
| SCHEMBL27726415 | 0.84 | ROCK2 (0.34) | ANPEPENPEPTDP1LMNAROCK2 | |
| SCHEMBL7882668 | 0.83 | ANPEP (0.44) | ANPEPENPEPSLC6A1GABRA5GABRB2 | |
| SCHEMBL15080323 | 0.83 | ROCK2 (0.33) | ANPEPENPEPTDP1ALDH1A1LMNA | |
| SCHEMBL17430747 | 0.81 | ANPEP (0.34) | ANPEPENPEPSLC6A1GABRA5GABRB2 | |
| SCHEMBL24483919 | 0.81 | ROCK2 (0.33) | ANPEPENPEPTDP1LMNAROCK2 | |
| SCHEMBL10232826 | 0.81 | ALOX5 (0.39) | ANPEPENPEPSLC1A2TDP1LMNA | |
| SCHEMBL7874370 | 0.81 | ALOX5 (0.39) | ANPEPENPEPSLC1A2TDP1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11161856-B2 | Spirocycle compounds and methods of making and using same | H. LUNDBECK A/S (DK) | 2021-11-02 | — | — | US | disclosed |
| WO-2020251957-A1 | PROSTAGLANDIN E2 RECEPTOR 4 ANTAGONISTS AND USES THEREOF | TEON THERAPEUTICS, INC. (US) | 2020-12-17 | — | — | WO | disclosed |
| US-10406140-B2 | 5-substituted benzimidazole and 5-substituted azabenzimidazole derivative both having AMPK activation effect | SHIONOGI & CO., LTD. (JP) | 2019-09-10 | — | — | US | disclosed |
| US-20190183866-A1 | 5-SUBSTITUTED BENZIMIDAZOLE AND 5-SUBSTITUTED AZABENZIMIDAZOLE DERIVATIVE BOTH HAVING AMPK ACTIVATION EFFECT | SHIONOGI & CO., LTD. (JP) | 2019-06-20 | — | — | US | disclosed |
| US-20160361295-A1 | FURO[3, 2-B] PYRR0L-3-ONES AS CATHESPIN S INHIBITORS | AMURA THERAPEUTICS LTD (GB) | 2016-12-15 | — | — | US | disclosed |
| CN-105367911-A | Auto part rubber coating TPV and preparation method thereof | ANHUI XIONGYA PLASTIC TECH CO LTD | 2016-03-02 | — | — | CN | disclosed |
| US-20160015685-A1 | FURO [3, 2-B] PYRR0L-3-0NES AS CATHESPIN S INHIBITORS | AMURA THERAPEUTICS LTD (GB) | 2016-01-21 | — | — | US | disclosed |
| US-20150164912-A1 | FURO[3, 2-B] PYRR0L-3-ONES AS CATHESPIN S INHIBITORS | AMURA THERAPEUTICS LTD (GB) | 2015-06-18 | — | — | US | disclosed |
| US-8933109-B2 | Furo[3, 2-B] pyrrol-3-ones as cathespin S inhibitors | AMURA LIMITED (GB) | 2015-01-13 | — | — | US | disclosed |
| US-20140038944-A1 | FURO[3, 2-B] PYRR0L-3-ONES AS CATHESPIN S INHIBITORS | AMURA THERAPEUTICS LIMITED (GB) | 2014-02-06 | — | — | US | disclosed |
| US-20110009386-A1 | FURO[3, 2-B] PYRR0L-3-0NES AS CATHESPIN S INHIBITORS | AMURA THERAPEUTICS LIMITED (GB) | 2011-01-13 | — | — | US | disclosed |
| WO-2010118207-A1 | PYRAZOLO [1, 5-A] PYRIMIDINE DERIVATIVES AS MTOR INHIBITORS | SCHERING CORPORATION (US) | 2010-10-14 | — | — | WO | disclosed |
| EP-1920042-B1 | PARTICLES CONTAINING PERFUME HAVING IMPROVED FRAGRANCED PROPERTIES | HENKEL AG & CO KGAA (DE) | 2010-06-23 | — | — | EP | disclosed |
| WO-2009112826-A1 | FURO [3, 2-B] PYRR0L-3-0NES AS CATHEPSIN S INHIBITORS | AMURA THERAPEUTICS LIMITED (GB) | 2009-09-17 | — | — | WO | disclosed |
| US-20090186830-A1 | MACROCYCLES AND THEIR USES | NOVARTIS AG (CH) | 2009-07-23 | — | — | US | disclosed |
| US-4329296-A | Branched chain and cycloaliphatic esters of the androstane and oestrane series and pharmaceutical compositions containing same | AKZONA INCORPORATED (US) | 1982-05-11 | — | — | US | disclosed |
| US-4312864-A | ANDROGENIC, ANABOLIC, ESTROGENIC, ANTIESTROGENIC | AKZONA INCORPORATED (US) | 1982-01-26 | — | — | US | disclosed |
| US-4307086-A | ANTIESTROGENS | AKZONA INCORPORATED (US) | 1981-12-22 | — | — | US | disclosed |
| US-4307087-A | ANTIESTROGENS | AKZONA INCORPORATED (US) | 1981-12-22 | — | — | US | disclosed |
| US-4212864-A | ANDROGENIC, ANABOLIC, ESTROGENIC AND ANTI-ESTROGENIC PROPERTIES | AKZONA INCORPORATED (US) | 1980-07-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11161856-B2 | Spirocycle compounds and methods of making and using same | OPRL1, MGLL, VKORC1L1 | ANPEP 4008/4885ENPEP 4302/4885SLC6A1 3063/4885 |
| US-20160015685-A1 | FURO [3, 2-B] PYRR0L-3-0NES AS CATHESPIN S INHIBITORS | CTSS, CTSL, CTSK | ANPEP 390/4885ENPEP 824/4885SLC6A1 2735/4885 |
| US-20090186830-A1 | MACROCYCLES AND THEIR USES | CYP11B2, OAT, CYP27A1 | ANPEP 1741/4885ENPEP 851/4885SLC6A1 1481/4885 |
| US-20160361295-A1 | FURO[3, 2-B] PYRR0L-3-ONES AS CATHESPIN S INHIBITORS | CTSS, CTSL, CTSK | ANPEP 470/4885ENPEP 1039/4885SLC6A1 2372/4885 |
| US-20190183866-A1 | 5-SUBSTITUTED BENZIMIDAZOLE AND 5-SUBSTITUTED AZABENZIMIDAZOLE DERIVATIVE BOTH HAVING AMPK ACTIVATION EFFECT | PRKAG2, PRKAB2, PRKAG1 | ANPEP 3129/4885ENPEP 3168/4885SLC6A1 2837/4885 |
| US-10406140-B2 | 5-substituted benzimidazole and 5-substituted azabenzimidazole derivative both having AMPK activation effect | PRKAG2, PRKAB2, PRKAG1 | ANPEP 3129/4885ENPEP 3168/4885SLC6A1 2837/4885 |
| US-20150164912-A1 | FURO[3, 2-B] PYRR0L-3-ONES AS CATHESPIN S INHIBITORS | CTSS, CTSL, CTSK | ANPEP 470/4885ENPEP 1039/4885SLC6A1 2372/4885 |
| US-20140038944-A1 | FURO[3, 2-B] PYRR0L-3-ONES AS CATHESPIN S INHIBITORS | CTSS, CTSL, CTSK | ANPEP 470/4885ENPEP 1039/4885SLC6A1 2372/4885 |
| US-20110009386-A1 | FURO[3, 2-B] PYRR0L-3-0NES AS CATHESPIN S INHIBITORS | CTSS, CTSL, CTSK | ANPEP 390/4885ENPEP 824/4885SLC6A1 2735/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.