Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1D | P25100 | 8/20 | 0.64 |
| ▸ | ADRA1A | P35348 | 8/20 | 0.64 |
| ▸ | ADRA1B | P35368 | 8/20 | 0.64 |
| ▸ | ADRB2 | P07550 | 3/20 | 0.64 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.64 |
| ▸ | HTR1A | P08908 | 1/20 | 0.64 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.64 |
| ▸ | DRD2 | P14416 | 1/20 | 0.64 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.64 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.64 |
| ▸ | HTR2A | P28223 | 1/20 | 0.64 |
| ▸ | HTR7 | P34969 | 1/20 | 0.64 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.64 |
| ▸ | DRD3 | P35462 | 1/20 | 0.64 |
| ▸ | HTR2B | P41595 | 1/20 | 0.64 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.64 |
| ▸ | SIGMAR1 | Q99720 | 7/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10820229 | 1.00 | ADRA1D (0.64) | ADRA1DADRA1AADRA1BADRB2ADRB1 | |
| SCHEMBL12284587 | 0.90 | ADRA1D (0.61) | ADRA1DADRA1AADRA1BADRB2ADRB1 | |
| SCHEMBL13623737 | 0.89 | ADRA1D (0.50) | ADRA1DADRA1AADRA1BADRB2ADRB1 | |
| SCHEMBL13623722 | 0.89 | ADRA1D (0.50) | ADRA1DADRA1AADRA1BADRB2ADRB1 | |
| SCHEMBL51245 | 0.87 | ADRA1D (0.67) | ADRA1DADRA1AADRA1BADRB2ADRB1 | |
| SCHEMBL9548034 | 0.87 | ADRA1D (0.67) | ADRA1DADRA1AADRA1BADRB2ADRB1 | |
| Hydrochloric Acid SCHEMBL9548113 | 0.86 | ADRA1D (0.66) | ADRA1DADRA1AADRA1BADRB2ADRB1 | |
| SCHEMBL11218388 | 0.84 | ADRA1D (0.66) | ADRA1DADRA1AADRA1BADRB2ADRB1 | |
| SCHEMBL14018837 | 0.82 | SIGMAR1 (0.49) | ADRA1DADRA1AADRA1BADRB2ADRB1 | |
| SCHEMBL14275116 | 0.82 | SMN1; SMN2 (0.47) | ADRA1DADRA1AADRA1BADRB2ADRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9198904-B2 | Pharmaceutical composition for oral administration | ASTELLAS PHARMA INC. (JP) | 2015-12-01 | — | — | US | disclosed |
| US-8017803-B2 | Process for the preparation of tamsulosin and intermediates thereof | HOVIONE INTER LTD. (CH) | 2011-09-13 | — | — | US | disclosed |
| US-20100331361-A1 | PHARMACEUTICAL COMPOSITION CONTAINING ALPHA-ADRENERGIC RECEPTOR ANTAGONIST AND AN ANTI-MUSCARINIC AGENT AND METHOD OF IMPROVING LOWER URINARY TRACT SYMPTOMS ASSOCIATED WITH PROSTATIC HYPERTROPHY | ASTELLAS PHARMA INC. (JP) | 2010-12-30 | — | — | US | disclosed |
| US-20100261770-A1 | PHARMACEUTICAL COMPOSITION FOR IMPROVING LOWER URINARY TRACT SYMPTOMS | ASTELLAS PHARMA INC. (JP) | 2010-10-14 | — | — | US | disclosed |
| US-20100233260-A1 | PHARMACEUTICAL COMPOSITION FOR ORAL ADMINISTRATION | ASTELLAS PHARMA INC. (JP) | 2010-09-16 | — | — | US | disclosed |
| US-7638649-B2 | Method of preparation of (R)-(−)-5-(2-aminopropyl)-2-methoxybenzenesulfonamide | ZENTIVA, K.S. (CZ) | 2009-12-29 | — | — | US | disclosed |
| US-20090234154-A1 | Process for the preparation of tamsulosin and intermediates thereof | HOVIONE INTER LTD. | 2009-09-17 | — | — | US | disclosed |
| US-20080319225-A1 | Method of Preparation of (R)-(-)-5(2-Aminopropyl)-2-Methoxybenzenesulfonamide | ZENTIVA, A.S. (CZ) | 2008-12-25 | — | — | US | disclosed |
| US-7329780-B2 | Method of preparing optically pure phenethylamine derivatives | CJ CORPORATION (KR) | 2008-02-12 | — | — | US | disclosed |
| US-20070269514-A1 | TABLET COMPOSITION WITH A PROLONGED RELEASE OF TAMSULOSIN | SYNTHON BV (NL) | 2007-11-22 | — | — | US | disclosed |
| US-7282606-B2 | Process for preparation of tamsulosin and its aralkylamine derivatives | WELL-BEING BIOCHEMICAL CORP. (TW) | 2007-10-16 | — | — | US | disclosed |
| US-20070197828-A1 | Method of preparing optically pure phenethylamine derivatives | CJ CORPORATION (KR) | 2007-08-23 | — | — | US | disclosed |
| US-20070015939-A1 | Process for preparation of tamsulosin and its aralkylamine derivatives | WELL-BEING BIOCHEMICAL CORP (TW) | 2007-01-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070269514-A1 | TABLET COMPOSITION WITH A PROLONGED RELEASE OF TAMSULOSIN | PTGER1, PTGER2, PTGER3 | ADRA1D 21/4885ADRA1A 29/4885ADRA1B 15/4885 |
| US-20090234154-A1 | Process for the preparation of tamsulosin and intermediates thereof | AVPR2, AVPR1B, TACR2 | ADRA1D 31/4885ADRA1A 57/4885ADRA1B 9/4885 |
| US-20080319225-A1 | Method of Preparation of (R)-(-)-5(2-Aminopropyl)-2-Methoxybenzenesulfonamide | NPSR1, TPSAB1, TPSB2 | ADRA1D 22/4885ADRA1A 45/4885ADRA1B 10/4885 |
| US-20100331361-A1 | PHARMACEUTICAL COMPOSITION CONTAINING ALPHA-ADRENERGIC RECEPTOR ANTAGONIST AND AN ANTI-MUSCARINIC AGENT AND METHOD OF IMPROVING LOWER URINARY TRACT SYMPTOMS ASSOCIATED WITH PROSTATIC HYPERTROPHY | ADRB1, ADRA2B, ADRB3 | ADRA1D 9/4885ADRA1A 6/4885ADRA1B 5/4885 |
| US-20070197828-A1 | Method of preparing optically pure phenethylamine derivatives | KMT2A, PNMT, PTMA | ADRA1D 92/4885ADRA1A 5/4885ADRA1B 57/4885 |
| US-20100261770-A1 | PHARMACEUTICAL COMPOSITION FOR IMPROVING LOWER URINARY TRACT SYMPTOMS | BPHL, REN, PRSS2 | ADRA1D 333/4885ADRA1A 501/4885ADRA1B 210/4885 |
| US-20070015939-A1 | Process for preparation of tamsulosin and its aralkylamine derivatives | ADRB1, ADRA2B, ADRA2A | ADRA1D 7/4885ADRA1A 5/4885ADRA1B 4/4885 |
| US-20100233260-A1 | PHARMACEUTICAL COMPOSITION FOR ORAL ADMINISTRATION | ADRB3, ADRB1, ADRA1B | ADRA1D 5/4885ADRA1A 9/4885ADRA1B 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.