SCHEMBL12378817

SCHEMBL12378817

CC(=O)O[C@H]1C=C[C@@H](C)C1

nearest known ligand 0.38

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
CA12 O43570 4/20 0.38
CA9 Q16790 4/20 0.38
CA1 P00915 2/20 0.37
CA2 P00918 2/20 0.37
TSHR P16473 2/20 0.37
ALOX15 P16050 1/20 0.32
CHRM2 P08172 4/20 0.31
CHRM4 P08173 4/20 0.31
CHRM1 P11229 4/20 0.31
CHRM3 P20309 4/20 0.31
CHRM5 P08912 2/20 0.31
POLB P06746 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25758606 1.00 CA12 (0.38) CA12CA9CA1CA2TSHR
SCHEMBL254386 0.86 CA12 (0.42) CA12CA9CA1CA2TSHR
SCHEMBL11746006 0.86 CA12 (0.42) CA12CA9CA1CA2TSHR
SCHEMBL2290500 0.86 CA12 (0.42) CA12CA9CA1CA2TSHR
SCHEMBL11548381 0.86 CA12 (0.42) CA12CA9CA1CA2TSHR
SCHEMBL11548379 0.86 CA12 (0.42) CA12CA9CA1CA2TSHR
SCHEMBL23436847 0.82 CA12 (0.38) CA12CA9CA1CA2TSHR
SCHEMBL25916380 0.80 ALDH1A1 (0.35)
SCHEMBL8355844 0.78 CA12 (0.38) CA12CA9CA1CA2TSHR
SCHEMBL307800 0.78 CA12 (0.38) CA12CA9CA1CA2TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 128 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230174477-A1 METHODS FOR SYNTHESIS OF THE TRICYCLIC PROSTAGLANDIN D2 METABOLITE METHYL ESTER PURDUE RESEARCH FOUNDATION 2023-06-08 US disclosed
US-20180170990-A1 MODIFIED POLYNUCLEOTIDES FOR THE PRODUCTION OF NUCLEAR PROTEINS MODERNATX, INC. 2018-06-21 US disclosed
US-20180125937-A1 MODIFIED NUCLEOSIDE, NUCLEOTIDE, AND NUCLEIC ACID COMPOSITIONS MODERNATX, INC. (US) 2018-05-10 US disclosed
US-20180086807-A1 MODIFIED POLYNUCLEOTIDES FOR THE PRODUCTION OF PROTEINS ASSOCIATED WITH HUMAN DISEASE MODERNATX, INC. 2018-03-29 US disclosed
US-9878056-B2 Modified polynucleotides for the production of cosmetic proteins and peptides MODERNATX, INC. (US) 2018-01-30 US disclosed
US-20180002393-A1 MODIFIED POLYNUCLEOTIDES FOR THE PRODUCTION OF ONCOLOGY-RELATED PROTEINS AND PEPTIDES ARES CAPITAL CORPORATION, AS AGENT 2018-01-04 US disclosed
US-20170368200-A1 MODIFIED POLYNUCLEOTIDES FOR THE PRODUCTION OF CYTOPLASMIC AND CYTOSKELETAL PROTEINS ARES CAPITAL CORPORATION, AS AGENT 2017-12-28 US disclosed
US-20170348436-A1 IN VIVO PRODUCTION OF PROTEINS ARES CAPITAL CORPORATION, AS AGENT 2017-12-07 US disclosed
US-9827332-B2 Modified polynucleotides for the production of proteins MODERNATX, INC. (US) 2017-11-28 US disclosed
US-9828416-B2 Modified polynucleotides for the production of secreted proteins MODERNATX, INC. (US) 2017-11-28 US disclosed
US-20130237592-A1 METHOD FOR PRODUCING A PROTEIN OF INTEREST AT THE SITE OF A CLOT modeRNA Therapeutics (US) 2013-09-12 US disclosed
US-20130236974-A1 METHOD FOR INCREASING THE PRODUCTION OF A PROTEIN OF INTEREST modeRNA Therapeutics (US) 2013-09-12 US disclosed
US-20130237593-A1 MULTI-SITE ADMINISTRATION modeRNA Therapeutics (US) 2013-09-12 US disclosed
US-20130165504-A1 METHODS OF INCREASING THE VIABILITY OR LONGEVITY OF AN ORGAN OR ORGAN EXPLANT modeRNA Therapeutics (US) 2013-06-27 US disclosed
US-20130156849-A1 MODIFIED NUCLEOSIDE, NUCLEOTIDE, AND NUCLEIC ACID COMPOSITIONS modeRNA Therapeutics (US) 2013-06-20 US disclosed
US-20130123481-A1 MODIFIED NUCLEOSIDES, NUCLEOTIDES, AND NUCLEIC ACIDS, AND USES THEREOF modeRNA Therapeutics (US) 2013-05-16 US disclosed
US-20130115272-A1 MODIFIED NUCLEOSIDES, NUCLEOTIDES, AND NUCLEIC ACIDS, AND USES THEREOF modeRNA Therapeutics (US) 2013-05-09 US disclosed
US-8304223-B2 Isoforms of pig liver esterase ENZYMICALS AG (DE) 2012-11-06 US disclosed
US-20110207186-A1 Isoforms of Pig Liver Esterase ENZYMICALS AG (DE) 2011-08-25 US disclosed
US-20100113582-A1 METHODS AND COMPOSITIONS FOR TREATING HIV INFECTIONS NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2010-05-06 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (15 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130237593-A1 MULTI-SITE ADMINISTRATION PHAX, IGF2BP1, NSUN2 CA12 2398/4885CA9 3719/4885CA1 3441/4885
US-20130123481-A1 MODIFIED NUCLEOSIDES, NUCLEOTIDES, AND NUCLEIC ACIDS, AND USES THEREOF ADAR, NT5C3B, NSUN2 CA12 3297/4885CA9 2016/4885CA1 4691/4885
US-20180170990-A1 MODIFIED POLYNUCLEOTIDES FOR THE PRODUCTION OF NUCLEAR PROTEINS POLN, POLRMT, MSH2 CA12 4804/4885CA9 4809/4885CA1 4862/4885
US-20130236974-A1 METHOD FOR INCREASING THE PRODUCTION OF A PROTEIN OF INTEREST IGF2BP1, PHAX, IGF2BP2 CA12 3283/4885CA9 3805/4885CA1 3851/4885
US-20130165504-A1 METHODS OF INCREASING THE VIABILITY OR LONGEVITY OF AN ORGAN OR ORGAN EXPLANT RNGTT, L3MBTL3, RNASE1 CA12 4826/4885CA9 4796/4885CA1 4576/4885
US-20180125937-A1 MODIFIED NUCLEOSIDE, NUCLEOTIDE, AND NUCLEIC ACID COMPOSITIONS NSUN2, RNMT, NSUN3 CA12 3349/4885CA9 3192/4885CA1 3762/4885
US-20170368200-A1 MODIFIED POLYNUCLEOTIDES FOR THE PRODUCTION OF CYTOPLASMIC AND CYTOSKELETAL PROTEINS POLRMT, POLN, PHAX CA12 4728/4885CA9 4783/4885CA1 4770/4885
US-20130156849-A1 MODIFIED NUCLEOSIDE, NUCLEOTIDE, AND NUCLEIC ACID COMPOSITIONS NSUN2, RNMT, NSUN3 CA12 3349/4885CA9 3192/4885CA1 3762/4885
US-20130237592-A1 METHOD FOR PRODUCING A PROTEIN OF INTEREST AT THE SITE OF A CLOT TIA1, PAIP1, PHAX CA12 2933/4885CA9 3538/4885CA1 3477/4885
US-20170348436-A1 IN VIVO PRODUCTION OF PROTEINS MSH2, POLRMT, POLN CA12 4661/4885CA9 4809/4885CA1 4762/4885
US-20230174477-A1 METHODS FOR SYNTHESIS OF THE TRICYCLIC PROSTAGLANDIN D2 METABOLITE METHYL ESTER PTGES2, PTGDR2, PTGES CA12 1162/4885CA9 2746/4885CA1 1990/4885
US-20110207186-A1 Isoforms of Pig Liver Esterase CES1, PIGO, PIGS CA12 3259/4885CA9 2432/4885CA1 2799/4885
US-20100113582-A1 METHODS AND COMPOSITIONS FOR TREATING HIV INFECTIONS SERPINB1, HPN, PRSS1 CA12 2604/4885CA9 2429/4885CA1 3327/4885
US-20180086807-A1 MODIFIED POLYNUCLEOTIDES FOR THE PRODUCTION OF PROTEINS ASSOCIATED WITH HUMAN DISEASE POLRMT, POLM, POLN CA12 4659/4885CA9 4722/4885CA1 4838/4885
US-20180002393-A1 MODIFIED POLYNUCLEOTIDES FOR THE PRODUCTION OF ONCOLOGY-RELATED PROTEINS AND PEPTIDES MSH2, POLN, MSH6 CA12 3958/4885CA9 4142/4885CA1 4789/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.