Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 5/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | HPGD | P15428 | 3/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 4/20 | 0.50 |
| ▸ | NPC1 | O15118 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | GLA | P06280 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.48 |
| ▸ | MMP13 | P45452 | 7/20 | 0.47 |
| ▸ | MMP2 | P08253 | 5/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22688131 | 0.84 | CYP1A2 (0.44) | RAB9AKDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL18034454 | 0.84 | ALDH1A1 (0.54) | RAB9AKDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL1244713 | 0.84 | ALDH1A1 (0.54) | RAB9AKDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL1244756 | 0.82 | ALOX15 (0.56) | RAB9AKDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL1245047 | 0.82 | ALDH1A1 (0.51) | RAB9AKDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL15850382 | 0.82 | ALDH1A1 (0.51) | RAB9AKDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL31229530 | 0.81 | ALDH1A1 (0.56) | KDM4EALDH1A1HPGDLMNANPC1 | |
| SCHEMBL6626487 | 0.79 | ALDH1A1 (0.49) | RAB9AKDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL6625018 | 0.79 | KDM4E (0.49) | RAB9AKDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL24038046 | 0.78 | RAB9A (0.48) | RAB9AKDM4EALDH1A1HPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 71 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118434822-A | Powdery pigment composition, method for producing powdery pigment composition, resin composition, and molded article | DIC株式会社 | 2024-08-02 | — | — | CN | disclosed |
| US-11981680-B2 | Substituted thienopyrroles as PAD4 inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2024-05-14 | — | — | US | disclosed |
| EP-3833671-B1 | SUBSTITUTED THIENOPYRROLES AS PAD4 INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2022-08-24 | — | — | EP | disclosed |
| US-20220127267-A1 | THIENO[3,2-B] PYRROLE[3,2-D]PYRIDAZINONE DERIVATIVES AND THEIR USE AS PKM2 DERIVATIVES FOR THE TREATMENT OF CANCER, OBESITY AND DIABETES RELATED DISORDERS | AGIOS PHARMACEUTICALS INC (US) | 2022-04-28 | — | — | US | disclosed |
| US-20220064180-A1 | SUBSTITUTED THIENOPYRROLES AS PAD4 INHIBITORS | LG ENERGY SOLUTION, LTD. (KR) | 2022-03-03 | — | — | US | disclosed |
| EP-3924056-A1 | THIENO[3,2-B] PYRROLE[3,2-D]PYRIDAZINONE DERIVATIVES AND THEIR USE AS PKM2 DERIVATIVES FOR THE TREATMENT OF CANCER, OBESITY AND DIABETES RELATED DISORDERS | Agios Pharmaceuticals, Inc. (US) | 2021-12-22 | — | — | EP | disclosed |
| CN-113646050-A | Thieno [3,2-B ] pyrrolo [3,2-D ] pyridazinone derivatives and their use as PKM2 derivatives for the treatment of cancer, obesity and diabetes related disorders | 安吉奥斯医药品有限公司 | 2021-11-12 | — | — | CN | disclosed |
| EP-3833671-A1 | SUBSTITUTED THIENOPYRROLES AS PAD4 INHIBITORS | Bristol-Myers Squibb Company (US) | 2021-06-16 | — | — | EP | disclosed |
| WO-2020167976-A1 | THIENO[3,2-B] PYRROLE[3,2-D]PYRIDAZINONE DERIVATIVES AND THEIR USE AS PKM2 DERIVATIVES FOR THE TREATMENT OF CANCER, OBESITY AND DIABETES RELATED DISORDERS | AGIOS PHARMACEUTICALS, INC. (US) | 2020-08-20 | — | — | WO | disclosed |
| WO-2020033490-A1 | SUBSTITUTED THIENOPYRROLES AS PAD4 INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2020-02-13 | — | — | WO | disclosed |
| WO-2007039773-A1 | USE OF FUSED PYRROLE CARBOXYLIC ACIDS FOR THE TREATMENT OF NEURODEGENERATIVE AND PSYCHIATRIC DISEASES AS D-AMINO ACID OXIDASE INHIBITORS | MERCK SHARP & DOHME LIMITED (GB) | 2007-04-12 | — | — | WO | disclosed |
| US-6828343-B2 | For therapy and prophylaxis of atherosclerosis, diabetes, insulin resistance, diabetic neuropathy, diabetic nephropathy, diabetic retinopathy, cataracts, hypercholesterolemia, hypertriglyceridemia, hyperlipidemia, hyperglycemia | PFIZER, INC. | 2004-12-07 | — | — | US | disclosed |
| EP-1391460-A1 | Tricyclic pyrrolyl amides as glycogen phosphorylase inhibitors | Pfizer Products Inc. (US) | 2004-02-25 | — | — | EP | disclosed |
| EP-1088824-B1 | Bicyclic pyrrolyl amides as glycogen phosphorylase inhibitors | PFIZER PROD INC (US) | 2004-01-07 | — | — | EP | disclosed |
| US-20030195361-A1 | Bicyclic pyrrolyl amides as glycogen phosphorylase inhibitors | PFIZER INC. | 2003-10-16 | — | — | US | disclosed |
| US-6576653-B2 | For therapy of diabetes, insulin resistance, diabetic neuropathy, diabetic nephropathy, diabetic retinopathy, cataracts, hyperglycemia, hypercholesterolemia, hypertension, hyperinsulinemia, hyperlipidemia, atherosclerosis | PFIZER INC. | 2003-06-10 | — | — | US | disclosed |
| US-20030004162-A1 | Use of glycogen phosphorylase inhibitors | TREADWAY JUDITH L (US) | 2003-01-02 | — | — | US | disclosed |
| US-20020183369-A1 | Bicyclic pyrrolyl amides as glycogen phosphorylase inhibitors | DU BOIS DAISY JOE (US) | 2002-12-05 | — | — | US | disclosed |
| EP-1136071-A2 | Use of glycogen phosphorylase inhibitors | Pfizer Products Inc. (US) | 2001-09-26 | — | — | EP | disclosed |
| EP-1088824-A2 | Bicyclic pyrrolyl amides as glycogen phosphorylase inhibitors | Pfizer Products Inc. (US) | 2001-04-04 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220127267-A1 | THIENO[3,2-B] PYRROLE[3,2-D]PYRIDAZINONE DERIVATIVES AND THEIR USE AS PKM2 DERIVATIVES FOR THE TREATMENT OF CANCER, OBESITY AND DIABETES RELATED DISORDERS | PDK2, PDK1, PDK3 | RAB9A 3825/4885KDM4E 480/4885ALDH1A1 509/4885 |
| US-20220064180-A1 | SUBSTITUTED THIENOPYRROLES AS PAD4 INHIBITORS | PADI4, PADI1, PADI6 | RAB9A 4487/4885KDM4E 120/4885ALDH1A1 142/4885 |
| US-20030195361-A1 | Bicyclic pyrrolyl amides as glycogen phosphorylase inhibitors | PYGL, GYS1, PYGM | RAB9A 3214/4885KDM4E 3388/4885ALDH1A1 1450/4885 |
| US-20020183369-A1 | Bicyclic pyrrolyl amides as glycogen phosphorylase inhibitors | PYGL, PYGM, PYGB | RAB9A 4025/4885KDM4E 2517/4885ALDH1A1 1268/4885 |
| US-20030004162-A1 | Use of glycogen phosphorylase inhibitors | PYGL, PYGM, GYS2 | RAB9A 4822/4885KDM4E 2087/4885ALDH1A1 2056/4885 |
| US-11981680-B2 | Substituted thienopyrroles as PAD4 inhibitors | PADI4, PADI1, PADI6 | RAB9A 4487/4885KDM4E 120/4885ALDH1A1 142/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.