Sugi Predict

Sugi Predict / Compounds / SCHEMBL1417702

SCHEMBL1417702

SCHEMBL1417702

N#Cc1ccc(C(=O)O)c(C(F)(F)F)c1

nearest known ligand 0.53

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
▸ TRPV4 Q9HBA0 1/20 0.53
▸ MRGPRX4 Q96LA9 1/20 0.50
▸ XDH P47989 4/20 0.47
▸ SLC22A12 Q96S37 4/20 0.47
▸ TMPRSS4 Q9NRS4 1/20 0.47
▸ MAP2K1 Q02750 1/20 0.46
▸ TAS2R14 Q9NYV8 2/20 0.45
▸ P4HB P07237 2/20 0.45
▸ CES2 O00748 1/20 0.44
▸ KIF11 P52732 1/20 0.44
▸ PTGS2 P35354 1/20 0.43
▸ KDM4E B2RXH2 1/20 0.42
▸ ALDH1A1 P00352 1/20 0.42
▸ HPGD P15428 1/20 0.42
▸ HSD17B10 Q99714 1/20 0.42
▸ ASPH Q12797 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7566278 0.88 P4HB (0.46) TRPV4MRGPRX4XDHSLC22A12TMPRSS4
SCHEMBL8612254 0.86 TRPV4 (0.50) TRPV4MRGPRX4XDHSLC22A12TMPRSS4
SCHEMBL23370123 0.86 TRPV4 (0.50) TRPV4MRGPRX4XDHSLC22A12TMPRSS4
SCHEMBL26020582 0.83 TRPV4 (0.51) TRPV4MRGPRX4SLC22A12TMPRSS4P4HB
SCHEMBL1417558 0.82 TMPRSS4 (0.48) TRPV4MRGPRX4TMPRSS4P4HBCES2
SCHEMBL22834192 0.82 TAS2R14 (0.45) TAS2R14CES2PTGS2KDM4EALDH1A1
SCHEMBL1417596 0.80 TRPV4 (0.48) TRPV4MRGPRX4XDHSLC22A12TMPRSS4
SCHEMBL24152864 0.79 TRPV4 (0.46) TRPV4MRGPRX4TMPRSS4P4HBCES2
SCHEMBL27218352 0.79 XDH (0.45) TRPV4MRGPRX4XDHSLC22A12TMPRSS4
SCHEMBL3157619 0.79 XDH (0.53) XDHSLC22A12MAP2K1ALDH1A1HSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116836081-A Ether epoxy toughening agent and preparation method and application thereof 中国林业科学研究院林产化学工业研究所 2023-10-03 — — CN claimed
WO-2025072539-A1 AMINO ACID COMPOUNDS WITH NITROGEN LINKERS AND USES THEREOF PLIANT THERAPEUTICS, INC. (US) 2025-04-03 — — WO disclosed
US-11780821-B2 Inhibitors of fibroblast activation protein Praxis Biotech LLC (US) 2023-10-10 — — US disclosed
US-11780821-B2 Inhibitors of fibroblast activation protein Praxis Biotech LLC (US) 2023-10-10 — — US disclosed
CN-116836081-A Ether epoxy toughening agent and preparation method and application thereof 中国林业科学研究院林产化学工业研究所 2023-10-03 — — CN disclosed
US-20230077268-A1 INDAZOLES AND AZAINDAZOLES AS LRRK2 INHIBITORS E-SCAPE BIO, INC. 2023-03-09 — — US disclosed
US-20230026801-A1 SSAO INHIBITORS AND USE THEREOF ECCOGENE INC. 2023-01-26 — — US disclosed
US-11427558-B1 Indazoles and azaindazoles as LRRK2 inhibitors ESCAPE Bio, Inc. (US) 2022-08-30 — — US disclosed
WO-2022155419-A1 INDAZOLES AND AZAINDAZOLES AS LRRK2 INHIBITORS ESCAPE Bio, Inc. (US) 2022-07-21 — — WO disclosed
EP-3997081-A1 INDAZOLES AND AZAINDAZOLES AS LRRK2 INHIBITORS Escape Bio, Inc. (US) 2022-05-18 — — EP disclosed
US-8377923-B2 Triazole derivative or salt thereof ASTELLAS PHARMA INC. (JP) 2013-02-19 — — US disclosed
US-8377923-B2 Triazole derivative or salt thereof ASTELLAS PHARMA INC. (JP) 2013-02-19 — — US disclosed
US-8377923-B2 Triazole derivative or salt thereof ASTELLAS PHARMA INC. (JP) 2013-02-19 — — US disclosed
US-20110105460-A1 TRIAZOLE DERIVATIVE OR SALT THEREOF ASTELLAS PHARMA INC. (JP) 2011-05-05 — — US disclosed
US-20110105460-A1 TRIAZOLE DERIVATIVE OR SALT THEREOF ASTELLAS PHARMA INC. (JP) 2011-05-05 — — US disclosed
US-20110105460-A1 TRIAZOLE DERIVATIVE OR SALT THEREOF ASTELLAS PHARMA INC. (JP) 2011-05-05 — — US disclosed
EP-2298747-A1 TRIAZOLE DERIVATIVE OR SALT THEREOF Astellas Pharma Inc. (JP) 2011-03-23 — — EP disclosed
EP-1390357-A2 ANTI-THROMBOTIC COMPOUNDS, PRODUCTION AND USE THEREOF AS MEDICAMENTS Boehringer Ingelheim Pharma GmbH & Co. KG (DE) 2004-02-25 — — EP disclosed
US-20020151534-A1 Antithrombotic compounds BOEHRINGER INGELHEIM PHARMA KG (DE) 2002-10-17 — — US disclosed
WO-2002062778-A2 ANTI-THROMBOTIC COMPOUNDS, PRODUCTION AND USE THEREOF AS MEDICAMENTS BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) 2002-08-15 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11427558-B1 Indazoles and azaindazoles as LRRK2 inhibitors LRRK2, PARK7, GDI2 TRPV4 4400/4885MRGPRX4 3778/4885XDH 3699/4885
US-20110105460-A1 TRIAZOLE DERIVATIVE OR SALT THEREOF HSD11B1, HSD11B2, HSD3B1 TRPV4 4738/4885MRGPRX4 4637/4885XDH 444/4885
US-20230026801-A1 SSAO INHIBITORS AND USE THEREOF SSB, HAO1, SORD TRPV4 2555/4885MRGPRX4 1264/4885XDH 22/4885
US-20230077268-A1 INDAZOLES AND AZAINDAZOLES AS LRRK2 INHIBITORS LRRK2, PARK7, GDI2 TRPV4 4400/4885MRGPRX4 3778/4885XDH 3699/4885
US-20020151534-A1 Antithrombotic compounds SERPINC1, PF4, F2 TRPV4 1849/4885MRGPRX4 2050/4885XDH 1452/4885
US-11780821-B2 Inhibitors of fibroblast activation protein FAP, FIBP, FRS2 TRPV4 3305/4885MRGPRX4 2435/4885XDH 3840/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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