SCHEMBL14935720

SCHEMBL14935720

Cc1c(C)c(S(=O)(=O)NC(=N)NCCC[C@@H](N)CC(=O)O)c(C)c2c1OC(C)(C)C2

nearest known ligand 0.36

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
PLG P00747 3/20 0.36
PLAU P00749 2/20 0.36
F2 P00734 1/20 0.36
ST14 Q9Y5Y6 1/20 0.36
HDAC3 O15379 1/20 0.34
HDAC6 Q9UBN7 1/20 0.34
F10 P00742 1/20 0.33
KLKB1 P03952 1/20 0.33
HSP90AA1 P07900 1/20 0.31
HSP90AB1 P08238 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4428216 0.91 PLG (0.40) PLGPLAUF2ST14F10
SCHEMBL15406855 0.89 PLG (0.37) PLGPLAUF2ST14HDAC3
SCHEMBL21690009 0.89 PLG (0.37) PLGPLAUF2ST14HDAC3
SCHEMBL20561401 0.89 PLG (0.37) PLGPLAUF2ST14HDAC3
SCHEMBL29401470 0.89 PLG (0.37) PLGPLAUF2ST14HDAC3
Hydrochloric Acid SCHEMBL16893616 0.88 PLG (0.37) PLGPLAUF2ST14HDAC3
Hydrochloric Acid SCHEMBL4994024 0.88 PLG (0.37) PLGPLAUF2ST14HDAC3
SCHEMBL29401478 0.87 PLG (0.39) PLGPLAUF2ST14HDAC3
SCHEMBL29358214 0.87 PLG (0.35) PLGPLAUF2ST14HDAC3
SCHEMBL16893905 0.86 PLG (0.37) PLGPLAUF2ST14HDAC3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 99 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024083220-A1 LIGAND-OLIGONUCLEOTIDE CONJUGATE AND LINKER FOR CONJUGATE 上海京新生物医药有限公司 2024-04-25 WO disclosed
US-20240131032-A1 AN ACTIVITY-GUIDED MAP OF ELECTROPHILE-CYSTEINE INTERACTIONS IN PRIMARY HUMAN IMMUNE CELLS THE SCRIPPS RESEARCH INSTITUTE 2024-04-25 US disclosed
US-20240123078-A1 COMPOUNDS AND METHODS FOR MODULATING IMMUNE-RELATED PROTEINS VIVIDION THERAPEUTICS, INC. 2024-04-18 US disclosed
US-11957787-B2 Wnt compositions and methods for purification THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) 2024-04-16 US disclosed
US-20240117363-A1 PRODUCTION OF UNNATURAL NUCLEOTIDES USING A CRISPR/CAS9 SYSTEM THE SCRIPPS RESEARCH INSTITUTE 2024-04-11 US disclosed
WO-2024043250-A1 CYCLIC PEPTIDE OR SALT THEREOF, AND MDMX INHIBITOR 富士フイルム株式会社 2024-02-29 WO disclosed
WO-2024043249-A1 CYCLIC PEPTIDE OR SALT THEREOF AND MDMX INHIBITOR 富士フイルム株式会社 2024-02-29 WO disclosed
US-11879145-B2 Reagents and methods for replication, transcription, and translation in semi-synthetic organisms THE SCRIPPS RESEARCH INSTITUTE (US) 2024-01-23 US disclosed
US-20230372536-A1 NANOMATERIAL AND METHODS OF USE THEREOF UNIVERSITY OF CONNECTICUT 2023-11-23 US disclosed
US-11761007-B2 Production of unnatural nucleotides using a CRISPR/Cas9 system THE SCRIPPS RESEARCH INSTITUTE (US) 2023-09-19 US disclosed
US-20160101145-A1 PEPTIDOMIMETIC MACROCYCLES AND FORMULATIONS THEREOF AILERON THERAPEUTICS, INC. 2016-04-14 US disclosed
US-20160052970-A1 PEPTIDOMIMETIC MACROCYCLES AND USE THEREOF IN REGULATING HIF1ALPHA AILERON THERAPEUTICS, INC. 2016-02-25 US disclosed
US-9096684-B2 Peptidomimetic macrocycles AILERON THERAPEUTICS, INC. (US) 2015-08-04 US disclosed
US-20150183825-A1 TRIAZOLE-CROSSLINKED AND THIOETHER-CROSSLINKED PEPTIDOMIMETIC MACROCYCLES AILERON THERAPEUTICS, INC. 2015-07-02 US disclosed
US-8987414-B2 Triazole-crosslinked and thioether-crosslinked peptidomimetic macrocycles AILERON THERAPEUTICS, INC. (US) 2015-03-24 US disclosed
US-20150051155-A1 PEPTIDOMIMETIC MACROCYCLES HOFFMANN-LA ROCHE, INC. 2015-02-19 US disclosed
US-8927500-B2 Peptidomimetic macrocycles AILERON THERAPEUTICS, INC. (US) 2015-01-06 US disclosed
US-20130274205-A1 PEPTIDOMIMETIC MACROCYCLES AILERON THERAPEUTICS, INC. 2013-10-17 US disclosed
US-20130210745-A1 TRIAZOLE-CROSSLINKED AND THIOETHER-CROSSLINKED PEPTIDOMIMETIC MACROCYCLES AILERON THERAPEUTICS, INC. (US) 2013-08-15 US disclosed
US-20130123169-A1 PEPTIDOMIMETIC MACROCYCLES AILERON THERAPEUTICS, INC. (US) 2013-05-16 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (12 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11957787-B2 Wnt compositions and methods for purification WNT3A, CTNNBL1, WNT1 PLG 1197/4885PLAU 1868/4885F2 4680/4885
US-20160101145-A1 PEPTIDOMIMETIC MACROCYCLES AND FORMULATIONS THEREOF MDM2, TP53, TP53BP1 PLG 2562/4885PLAU 2259/4885F2 3230/4885
US-20240123078-A1 COMPOUNDS AND METHODS FOR MODULATING IMMUNE-RELATED PROTEINS CD4, ICOS, NFATC1 PLG 3996/4885PLAU 3594/4885F2 3360/4885
US-20240131032-A1 AN ACTIVITY-GUIDED MAP OF ELECTROPHILE-CYSTEINE INTERACTIONS IN PRIMARY HUMAN IMMUNE CELLS GSTK1, GSTA2, GSTA1 PLG 4142/4885PLAU 4369/4885F2 3161/4885
US-20230372536-A1 NANOMATERIAL AND METHODS OF USE THEREOF ILK, EPCAM, MMP8 PLG 354/4885PLAU 71/4885F2 2360/4885
US-20150051155-A1 PEPTIDOMIMETIC MACROCYCLES TP53, MDM2, MDM4 PLG 2025/4885PLAU 2445/4885F2 2798/4885
US-20130123169-A1 PEPTIDOMIMETIC MACROCYCLES GHRHR, GHSR, GHITM PLG 1437/4885PLAU 671/4885F2 2487/4885
US-20160052970-A1 PEPTIDOMIMETIC MACROCYCLES AND USE THEREOF IN REGULATING HIF1ALPHA HIF1A, HIF1AN, EGLN3 PLG 1977/4885PLAU 2190/4885F2 3942/4885
US-11879145-B2 Reagents and methods for replication, transcription, and translation in semi-synthetic organisms RNGTT, MAX, POLRMT PLG 3503/4885PLAU 3166/4885F2 3231/4885
US-20130210745-A1 TRIAZOLE-CROSSLINKED AND THIOETHER-CROSSLINKED PEPTIDOMIMETIC MACROCYCLES IL33, TPR, CDC37 PLG 995/4885PLAU 1595/4885F2 769/4885
US-20130274205-A1 PEPTIDOMIMETIC MACROCYCLES PROKR1, GLP1R, PROKR2 PLG 676/4885PLAU 374/4885F2 3155/4885
US-20150183825-A1 TRIAZOLE-CROSSLINKED AND THIOETHER-CROSSLINKED PEPTIDOMIMETIC MACROCYCLES IL33, TPR, CDC37 PLG 995/4885PLAU 1595/4885F2 769/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.