SCHEMBL14948862

SCHEMBL14948862

Nc1nc2c([nH]c(=O)n2C2OC(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)C(O)C2O)c(=O)[nH]1

nearest known ligand 0.66

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
P2RX3 P56373 1/20 0.61
P2RY2 P41231 9/20 0.58
TGM2 P21980 1/20 0.54
UMPS P11172 1/20 0.52
P2RY6 Q15077 4/20 0.52
P2RY4 P51582 2/20 0.52
KRAS P01116 2/20 0.51
FUT5 Q11128 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6465095 1.00 P2RX3 (0.61) P2RX3P2RY2TGM2UMPSP2RY6
SCHEMBL29868101 0.99 P2RX3 (0.60) P2RX3P2RY2TGM2UMPSP2RY6
SCHEMBL15038134 0.91 P2RY2 (0.53) P2RX3P2RY2TGM2UMPSP2RY6
SCHEMBL16160997 0.90 UMPS (0.51) P2RX3P2RY2TGM2UMPSP2RY6
SCHEMBL5315097 0.85 TGM2 (0.58) P2RX3P2RY2TGM2P2RY6P2RY4
SCHEMBL5315091 0.85 TGM2 (0.58) P2RX3P2RY2TGM2P2RY6P2RY4
SCHEMBL17893049 0.85 PNP (0.66) P2RX3P2RY2TGM2P2RY6P2RY4
SCHEMBL14930893 0.84 P2RX3 (0.44) P2RX3P2RY2TGM2UMPSP2RY6
SCHEMBL154964 0.84 POLB (0.55) P2RX3P2RY2P2RY6P2RY4FUT5
SCHEMBL15794376 0.84 TGM2 (0.59) P2RX3P2RY2TGM2P2RY6P2RY4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20190255194-A1 ALTERNATIVE NUCLEIC ACID MOLECULES AND USES THEREOF MODERNATX INC (US) 2019-08-22 US disclosed
US-20170252461-A1 HETEROLOGOUS UNTRANSLATED REGIONS FOR MRNA MODERNATX, INC. 2017-09-07 US disclosed
US-20170136131-A1 ALTERNATIVE NUCLEIC ACID MOLECULES AND USES THEREOF Modema Therapeutics, Inc. (US) 2017-05-18 US disclosed
US-20170136132-A1 ALTERNATIVE NUCLEIC ACID MOLECULES AND USES THEREOF MODERNA THERAPEUTICS, INC. (US) 2017-05-18 US disclosed
US-20170056528-A1 MODIFIED NUCLEOSIDES, NUCLEOTIDES, AND NUCLEIC ACIDS, AND USES THEREOF MODERNATX, INC. 2017-03-02 US disclosed
US-20160354493-A1 MODIFIED NUCLEIC ACID MOLECULES AND USES THEREOF MODERNATX, INC. 2016-12-08 US disclosed
US-20160354491-A1 MODIFIED NUCLEIC ACID MOLECULES AND USES THEREOF MODERNA THERAPEUTICS INC (US) 2016-12-08 US disclosed
US-20160354490-A1 MODIFIED NUCLEIC ACID MOLECULES AND USES THEREOF MODERNA THERAPEUTICS INC (US) 2016-12-08 US disclosed
US-20160354492-A1 MODIFIED NUCLEIC ACID MOLECULES AND USES THEREOF MODERNA THERAPEUTICS INC (US) 2016-12-08 US disclosed
US-20160348099-A1 MODIFIED NUCLEIC ACID MOLECULES AND USES THEREOF MODERNA THERAPEUTICS INC (US) 2016-12-01 US disclosed
US-20160022840-A1 HETEROLOGOUS UNTRANSLATED REGIONS FOR MRNA MODERNATX, INC. 2016-01-28 US disclosed
US-20160022774-A1 DIAGNOSIS AND TREATMENT OF FIBROSIS MODERNATX, INC. 2016-01-28 US disclosed
US-20150307542-A1 MODIFIED NUCLEIC ACID MOLECULES AND USES THEREOF MODERNATX, INC. 2015-10-29 US disclosed
WO-2015089511-A2 MODIFIED NUCLEIC ACID MOLECULES AND USES THEREOF MODERNA THERAPEUTICS, INC. (US) 2015-06-18 WO disclosed
US-20150167017-A1 ALTERNATIVE NUCLEIC ACID MOLECULES AND USES THEREOF MODERNA THERAPEUTICS, INC. 2015-06-18 US disclosed
US-20140378538-A1 METHODS OF RESPONDING TO A BIOTHREAT MODERNATX, INC. 2014-12-25 US disclosed
US-20140343129-A1 MODIFIED NUCLEIC ACIDS, AND ACUTE CARE USES THEREOF MODERNATX, INC. 2014-11-20 US disclosed
WO-2014093924-A1 MODIFIED NUCLEIC ACID MOLECULES AND USES THEREOF MODERNA THERAPEUTICS, INC. (US) 2014-06-19 WO disclosed
WO-2013130161-A1 METHODS OF RESPONDING TO A BIOTHREAT modeRNA Therapeutics (US) 2013-09-06 WO disclosed
US-20130123481-A1 MODIFIED NUCLEOSIDES, NUCLEOTIDES, AND NUCLEIC ACIDS, AND USES THEREOF modeRNA Therapeutics (US) 2013-05-16 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (15 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160354492-A1 MODIFIED NUCLEIC ACID MOLECULES AND USES THEREOF NSUN2, ADAR, NSUN3 P2RX3 3314/4885P2RY2 2899/4885TGM2 1916/4885
US-20130123481-A1 MODIFIED NUCLEOSIDES, NUCLEOTIDES, AND NUCLEIC ACIDS, AND USES THEREOF ADAR, NT5C3B, NSUN2 P2RX3 736/4885P2RY2 558/4885TGM2 2181/4885
US-20170056528-A1 MODIFIED NUCLEOSIDES, NUCLEOTIDES, AND NUCLEIC ACIDS, AND USES THEREOF ADAR, NT5C3B, NSUN2 P2RX3 736/4885P2RY2 558/4885TGM2 2181/4885
US-20160348099-A1 MODIFIED NUCLEIC ACID MOLECULES AND USES THEREOF NSUN2, ADAR, NSUN3 P2RX3 3314/4885P2RY2 2899/4885TGM2 1916/4885
US-20160022774-A1 DIAGNOSIS AND TREATMENT OF FIBROSIS MMP1, COL2A1, COL1A1 P2RX3 2167/4885P2RY2 2517/4885TGM2 535/4885
US-20170136132-A1 ALTERNATIVE NUCLEIC ACID MOLECULES AND USES THEREOF NSUN2, RNGTT, NSUN3 P2RX3 2081/4885P2RY2 2786/4885TGM2 2234/4885
US-20190255194-A1 ALTERNATIVE NUCLEIC ACID MOLECULES AND USES THEREOF NSUN2, RNGTT, NSUN3 P2RX3 2081/4885P2RY2 2786/4885TGM2 2234/4885
US-20160354490-A1 MODIFIED NUCLEIC ACID MOLECULES AND USES THEREOF NSUN2, ADAR, NSUN3 P2RX3 3314/4885P2RY2 2899/4885TGM2 1916/4885
US-20160354491-A1 MODIFIED NUCLEIC ACID MOLECULES AND USES THEREOF NSUN2, ADAR, NSUN3 P2RX3 3314/4885P2RY2 2899/4885TGM2 1916/4885
US-20170136131-A1 ALTERNATIVE NUCLEIC ACID MOLECULES AND USES THEREOF NSUN2, RNGTT, NSUN3 P2RX3 2081/4885P2RY2 2786/4885TGM2 2234/4885
US-20160354493-A1 MODIFIED NUCLEIC ACID MOLECULES AND USES THEREOF NSUN2, ADAR, NSUN3 P2RX3 3314/4885P2RY2 2899/4885TGM2 1916/4885
US-20160022840-A1 HETEROLOGOUS UNTRANSLATED REGIONS FOR MRNA RNGTT, NSUN3, CPSF6 P2RX3 3487/4885P2RY2 3990/4885TGM2 3649/4885
US-20150307542-A1 MODIFIED NUCLEIC ACID MOLECULES AND USES THEREOF NSUN2, ADAR, NSUN3 P2RX3 3314/4885P2RY2 2899/4885TGM2 1916/4885
US-20170252461-A1 HETEROLOGOUS UNTRANSLATED REGIONS FOR MRNA RNGTT, NSUN3, CPSF6 P2RX3 3487/4885P2RY2 3990/4885TGM2 3649/4885
US-20140378538-A1 METHODS OF RESPONDING TO A BIOTHREAT POLRMT, RNMT, RNGTT P2RX3 3056/4885P2RY2 2414/4885TGM2 2094/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.