Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 7/20 | 0.59 |
| ▸ | CA1 | P00915 | 4/20 | 0.59 |
| ▸ | CA9 | Q16790 | 4/20 | 0.59 |
| ▸ | CA12 | O43570 | 3/20 | 0.59 |
| ▸ | CA7 | P43166 | 3/20 | 0.59 |
| ▸ | CA14 | Q9ULX7 | 3/20 | 0.59 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.53 |
| ▸ | GAA | P10253 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.46 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | EGFR | P00533 | 3/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28205156 | 0.94 | CA2 (0.53) | CA2CA1CA9CA12CA7 | |
| SCHEMBL29541454 | 0.86 | ALDH1A1 (0.49) | CA2CA1CA9CA12CA7 | |
| SCHEMBL17363910 | 0.85 | HSD17B10 (0.62) | CA2CA1CA9CA12CA7 | |
| SCHEMBL2642603 | 0.85 | CA2 (0.61) | CA2CA1CA9CA12CA7 | |
| SCHEMBL4419601 | 0.85 | PTGS2 (0.63) | CA2CA1CA9CA12CA7 | |
| SCHEMBL11745347 | 0.84 | PTGS2 (0.56) | CA2CA1CA9CA12CA7 | |
| SCHEMBL11745342 | 0.84 | PTGS2 (0.56) | CA2CA1CA9CA12CA7 | |
| SCHEMBL4904491 | 0.83 | ALDH1A1 (0.47) | CA2GAAMEN1KMT2ATSHR | |
| SCHEMBL27319746 | 0.83 | CA2 (0.59) | CA2CA1CA9CA12CA7 | |
| SCHEMBL18547926 | 0.83 | ALDH1A1 (0.65) | CA2GAAMEN1KMT2ATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 63 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105777669-B | The method that 2 ethyoxyl 5 (the base sulfonyl of 4 methyl piperazine 1) benzoic acid are prepared with gaultherolin | 锦州医科大学 | 2018-03-20 | — | — | CN | claimed |
| CN-105777669-A | Method for preparing 2-ethyoxyl-5-(4-methyl piperazine-1-sulfonyl) benzoic acid from methyl salicylate | 锦州医科大学 | 2016-07-20 | — | — | CN | claimed |
| CN-117800904-A | ROR gamma inhibitors containing sulfonyl structures | 正大天晴药业集团股份有限公司 | 2024-04-02 | — | — | CN | disclosed |
| WO-2024028169-A1 | NOVEL SPECIFICALLY SUBSTITUTED THIOPHENOLIC COMPOUNDS | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2024-02-08 | — | — | WO | disclosed |
| US-20240010641-A1 | N-Linked Glycosylation Inhibitors and Methods of Using Same | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2024-01-11 | — | — | US | disclosed |
| CN-113166061-B | ROR gamma inhibitors containing sulfonyl structures | 正大天晴药业集团股份有限公司 | 2023-11-21 | — | — | CN | disclosed |
| CN-110511173-B | Indole alkyl piperazine benzamide compound and application thereof | 复旦大学 | 2023-06-23 | — | — | CN | disclosed |
| US-11396503-B2 | Sulfonyl substituted bicyclic compound which acts as ROR inhibitor | CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD. (CN) | 2022-07-26 | — | — | US | disclosed |
| CN-111094267-B | Sulfonyl-substituted bicyclic compounds as ROR gamma inhibitors | 正大天晴药业集团股份有限公司 | 2022-06-14 | — | — | CN | disclosed |
| WO-2022051286-A1 | N-LINKED GLYCOSYLATION INHIBITORS AND METHODS OF USING SAME | YALE UNIVERSITY (US) | 2022-03-10 | — | — | WO | disclosed |
| US-11219625-B2 | Inhibitors of N-linked glycosylation and methods using same | YALE UNIVERSITY (US) | 2022-01-11 | — | — | US | disclosed |
| US-7582660-B2 | 2-thio-substituted imidazole derivatives and their use in pharmaceutics | C-A-I-R BIOSCIENCES GMBH (DE) | 2009-09-01 | — | — | US | disclosed |
| CN-100396677-C | 2-thio-substituted imidazole derivatives and their use in pharmaceutics | MERCKLE GMBH (DE) | 2008-06-25 | — | — | CN | disclosed |
| US-20060235054-A1 | 2-Thio-substituted imidazole derivatives and their use in pharmaceutics | MERCKLE-GMBH (DE) | 2006-10-19 | — | — | US | disclosed |
| WO-2005110981-A1 | AMINOALCOHOL DERIVATIVES | ASTELLAS PHARMA INC. (JP) | 2005-11-24 | — | — | WO | disclosed |
| CN-1675197-A | 2-thio-substituted imidazole derivatives and their use in pharmaceutics | MERCKLE GMBH (DE) | 2005-09-28 | — | — | CN | disclosed |
| US-20050130983-A1 | Pyrrolopyrimidinone derivatives, process for preparation thereof, and method of using and composition comprising them | IN2GEN CO., LTD. (KR) | 2005-06-16 | — | — | US | disclosed |
| US-20040106653-A1 | Aminoalcohol derivatives | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2004-06-03 | — | — | US | disclosed |
| WO-2004045610-A1 | AMINOALCOHOL DERIVATIVES AND THEIR USE AS BETA-3 ADRENERGIC RECEPTOR AGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD (JP) | 2004-06-03 | — | — | WO | disclosed |
| EP-1362858-A1 | Pyrrolopyrimidinone derivates, process of preparation and use | SK Chemicals Co., Ltd. (KR) | 2003-11-19 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240010641-A1 | N-Linked Glycosylation Inhibitors and Methods of Using Same | ENGASE, UGGT1, GALNT1 | CA2 3676/4885CA1 2832/4885CA9 1394/4885 |
| US-20060235054-A1 | 2-Thio-substituted imidazole derivatives and their use in pharmaceutics | IL2, TPMT, IFNG | CA2 1113/4885CA1 3585/4885CA9 3579/4885 |
| US-11219625-B2 | Inhibitors of N-linked glycosylation and methods using same | ENGASE, FUT5, B3GNT2 | CA2 3839/4885CA1 2582/4885CA9 1949/4885 |
| US-20050130983-A1 | Pyrrolopyrimidinone derivatives, process for preparation thereof, and method of using and composition comprising them | DHPS, SDHA, FDPS | CA2 4395/4885CA1 4438/4885CA9 3146/4885 |
| US-11396503-B2 | Sulfonyl substituted bicyclic compound which acts as ROR inhibitor | RORC, RORA, RORB | CA2 2877/4885CA1 2135/4885CA9 2273/4885 |
| US-20040106653-A1 | Aminoalcohol derivatives | FANCD2, FANCI, HRH2 | CA2 696/4885CA1 2450/4885CA9 1808/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.