Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 3/20 | 0.70 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.70 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.70 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.70 |
| ▸ | NPC1 | O15118 | 1/20 | 0.70 |
| ▸ | HPGD | P15428 | 1/20 | 0.70 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.70 |
| ▸ | RAB9A | P51151 | 1/20 | 0.70 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | HRH1 | P35367 | 1/20 | 0.43 |
| ▸ | SCN1A | P35498 | 1/20 | 0.43 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.43 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.43 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.39 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14227426 | 1.00 | CYP2D6 (0.70) | CYP2D6CYP1A2CYP2C19KDM4ENPC1 | |
| SCHEMBL14227427 | 1.00 | CYP2D6 (0.70) | CYP2D6CYP1A2CYP2C19KDM4ENPC1 | |
| SCHEMBL16931709 | 1.00 | CYP2D6 (0.70) | CYP2D6CYP1A2CYP2C19KDM4ENPC1 | |
| SCHEMBL19841237 | 1.00 | CYP2D6 (0.70) | CYP2D6CYP1A2CYP2C19KDM4ENPC1 | |
| SCHEMBL3088977 | 1.00 | CYP2D6 (0.70) | CYP2D6CYP1A2CYP2C19KDM4ENPC1 | |
| SCHEMBL20833321 | 1.00 | CYP2D6 (0.70) | CYP2D6CYP1A2CYP2C19KDM4ENPC1 | |
| SCHEMBL20833053 | 0.95 | CYP2D6 (0.63) | CYP2D6CYP1A2CYP2C19KDM4ENPC1 | |
| SCHEMBL20833279 | 0.95 | CYP2D6 (0.63) | CYP2D6CYP1A2CYP2C19KDM4ENPC1 | |
| SCHEMBL20833147 | 0.95 | CYP2D6 (0.63) | CYP2D6CYP1A2CYP2C19KDM4ENPC1 | |
| SCHEMBL20850797 | 0.93 | CYP2D6 (0.61) | CYP2D6CYP1A2CYP2C19KDM4ENPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11718638-B2 | Compounds, compositions and methods for synthesis | WAVE LIFE SCIENCES LTD. (SG) | 2023-08-08 | — | — | US | disclosed |
| EP-4137572-A1 | CHIRAL DESIGN | Wave Life Sciences Ltd. (SG) | 2023-02-22 | — | — | EP | disclosed |
| EP-2872147-B1 | METHOD FOR MAKING CHIRAL OLIGONUCLEOTIDES | WAVE LIFE SCIENCES LTD (SG) | 2022-12-21 | — | — | EP | disclosed |
| US-20220145300-A1 | OLIGONUCLEOTIDE COMPOSITIONS AND METHODS OF USE THEREOF | WAVE LIFE SCIENCES LTD. (SG) | 2022-05-12 | — | — | US | disclosed |
| US-20220098585-A1 | OLIGONUCLEOTIDE COMPOSITIONS AND METHODS THEREOF | WAVE LIFE SCIENCES LTD. (SG) | 2022-03-31 | — | — | US | disclosed |
| US-20210130821-A1 | CHIRAL CONTROL | WAVE LIFE SCIENCES LTD. (SG) | 2021-05-06 | — | — | US | disclosed |
| CN-112007045-A | Chiral control | 波涛生命科学有限公司 | 2020-12-01 | — | — | CN | disclosed |
| US-20200231620-A1 | TECHNOLOGIES FOR OLIGONUCLEOTIDE PREPARATION | WAVE LIFE SCIENCES LTD. (SG) | 2020-07-23 | — | — | US | disclosed |
| CN-104661664-B | Chiral control | 波涛生命科学有限公司 | 2020-07-03 | — | — | CN | disclosed |
| US-20200157545-A1 | OLIGONUCLEOTIDE COMPOSITIONS AND METHODS OF USE THEREOF | WAVE LIFE SCIENCES LTD. (SG) | 2020-05-21 | — | — | US | disclosed |
| WO-2018067973-A1 | OLIGONUCLEOTIDE COMPOSITIONS AND METHODS THEREOF | WAVE LIFE SCIENCES LTD. (SG) | 2018-04-12 | — | — | WO | disclosed |
| US-9885037-B2 | — | — | 2018-02-06 | — | — | US | disclosed |
| WO-2017192664-A1 | OLIGONUCLEOTIDE COMPOSITIONS AND METHODS THEREOF | WAVE LIFE SCIENCES LTD. (SG) | 2017-11-09 | — | — | WO | disclosed |
| US-9701601-B2 | Optically active axially chiral alpha-allenic alcohol, synthesis method and use thereof | SHANGHAI INSTITUTE OF ORGANIC CHEMISTRY, CHINESE ACADEMY OF SCIENCES (CN) | 2017-07-11 | — | — | US | disclosed |
| US-9695211-B2 | Method for the synthesis of phosphorus atom modified nucleic acids | WAVE LIFE SCIENCES JAPAN, INC. (JP) | 2017-07-04 | — | — | US | disclosed |
| US-9695211-B2 | Method for the synthesis of phosphorus atom modified nucleic acids | WAVE LIFE SCIENCES JAPAN, INC. (JP) | 2017-07-04 | — | — | US | disclosed |
| US-20160347780-A1 | METHOD FOR THE SYNTHESIS OF PHOSPHORUS ATOM MODIFIED NUCLEIC ACIDS | WAVE LIFE SCIENCES LTD. (SG) | 2016-12-01 | — | — | US | disclosed |
| US-20160347780-A1 | METHOD FOR THE SYNTHESIS OF PHOSPHORUS ATOM MODIFIED NUCLEIC ACIDS | WAVE LIFE SCIENCES LTD. (SG) | 2016-12-01 | — | — | US | disclosed |
| CN-104661664-A | Chiral control | WAVE LIFE SCIENCES PTY LTD | 2015-05-27 | — | — | CN | disclosed |
| US-20150105567-A1 | OPTICALLY ACTIVE AXIALLY CHIRAL ALPHA-ALLENIC ALCOHOL, SYNTHESIS METHOD AND USE THEREOF | SHANGHAI INSTITUTE OF ORGANIC CHEMISTRY, CHINESE ACADEMY OF SCIENCES (CN) | 2015-04-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11718638-B2 | Compounds, compositions and methods for synthesis | ALKBH1, DUT, RNGTT | CYP2D6 888/4885CYP1A2 4059/4885CYP2C19 3230/4885 |
| US-20210130821-A1 | CHIRAL CONTROL | RNGTT, POLI, NSUN3 | CYP2D6 2805/4885CYP1A2 4590/4885CYP2C19 4466/4885 |
| US-20220145300-A1 | OLIGONUCLEOTIDE COMPOSITIONS AND METHODS OF USE THEREOF | TARDBP, GRN, FUS | CYP2D6 4837/4885CYP1A2 4884/4885CYP2C19 4880/4885 |
| US-20200157545-A1 | OLIGONUCLEOTIDE COMPOSITIONS AND METHODS OF USE THEREOF | RNASE1, RNASEH1, RNASEL | CYP2D6 3117/4885CYP1A2 4868/4885CYP2C19 4805/4885 |
| US-20200231620-A1 | TECHNOLOGIES FOR OLIGONUCLEOTIDE PREPARATION | POLRMT, DCLRE1B, RNGTT | CYP2D6 3929/4885CYP1A2 4658/4885CYP2C19 4618/4885 |
| US-20160347780-A1 | METHOD FOR THE SYNTHESIS OF PHOSPHORUS ATOM MODIFIED NUCLEIC ACIDS | ADAR, PNP, NUDT1 | CYP2D6 2661/4885CYP1A2 4741/4885CYP2C19 4231/4885 |
| US-20150105567-A1 | OPTICALLY ACTIVE AXIALLY CHIRAL ALPHA-ALLENIC ALCOHOL, SYNTHESIS METHOD AND USE THEREOF | ALDH18A1, ADH1C, ADH1A | CYP2D6 1087/4885CYP1A2 418/4885CYP2C19 1422/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.