Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | IDO1 | P14902 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | P2RX7 | Q99572 | 6/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | NLRP1 | Q9C000 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | CTRC | Q99895 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11518880 | 0.84 | HDAC3 (0.42) | CYP3A4HDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL15093979 | 0.83 | CYP3A4 (0.48) | CYP3A4HDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL12603786 | 0.83 | ALOX5 (0.41) | CYP3A4CYP1A2CYP2C19 | |
| SCHEMBL8337975 | 0.82 | CYP3A4 (0.40) | CYP3A4HDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL998743 | 0.81 | CYP3A4 (0.43) | CYP3A4HDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL27628619 | 0.81 | CYP3A4 (0.43) | CYP3A4HDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL8418306 | 0.81 | CYP3A4 (0.48) | CYP3A4IDO1POLBGAALMNA | |
| SCHEMBL3782085 | 0.80 | IDO1 (0.44) | CYP3A4IDO1MAPK1CYP1A2CYP2C9 | |
| SCHEMBL3162880 | 0.79 | IDO1 (0.61) | CYP3A4HDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL193074 | 0.79 | CYP3A4 (0.46) | CYP3A4HDAC3HDAC1HDAC2HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 95 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023122298-A1 | PROTEIN STABILIZING COMPOUNDS CONTAINING USP28 AND/OR USP25 TARGETING LIGANDS | Stablix, Inc. (US) | 2023-06-29 | — | — | WO | disclosed |
| US-20230102258-A1 | C5AR ANTAGONISTS | CHEMOCENTRYX, INC. | 2023-03-30 | — | — | US | disclosed |
| EP-4005572-A1 | BENZAMIDE DERIVATIVE, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL COMPOSITION COMPRISING SAME AS ACTIVE INGREDIENT FOR PREVENTION OR TREATMENT OF CANCER | Korea Research Institute of Chemical Technology (KR) | 2022-06-01 | — | — | EP | disclosed |
| EP-3728237-B1 | SUBSTITUTED THIOPHENYLURACILS , THEIR SALTS AND USE OF SAID COMPOUNDS AS HERBICIDAL AGENTS | SYNGENTA CROP PROTECTION AG (CH) | 2022-02-09 | — | — | EP | disclosed |
| US-11214541-B2 | Substituted 6,7-dihydro-5H-benzo[7]annulene compounds, processes for their preparation and therapeutic uses thereof | SANOFI (FR) | 2022-01-04 | — | — | US | disclosed |
| US-20210395243-A1 | PESTICIDAL COMPOUNDS | BASF SE (DE) | 2021-12-23 | — | — | US | disclosed |
| US-20210276960-A1 | INHIBITORS OF TISSUE TRANSGLUTAMINASE 2 (TG2) AND USES THEREOF | NORTHWESTERN UNIVERSITY | 2021-09-09 | — | — | US | disclosed |
| WO-2021158463-A1 | DIAMINE-LINKED RECEPTOR-SPECIFIC CYCLIC PEPTIDES | PALATIN TECHNOLOGIES, INC. (US) | 2021-08-12 | — | — | WO | disclosed |
| US-20210220376-A1 | ADDICTION TREATMENT OF AN ALCOHOL-CONSUMING PATIENT POPULATION | AMYGDALA NEUROSCIENCES, INC. (US) | 2021-07-22 | — | — | US | disclosed |
| US-20210145844-A1 | COMBINATION THERAPY FOR NICOTINE ADDICTION | AMYGDALA NEUROSCIENCES, INC. (US) | 2021-05-20 | — | — | US | disclosed |
| WO-2008019477-A1 | VIRAL POLYMERASE INHIBITORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2008-02-21 | — | — | WO | disclosed |
| US-20080032981-A1 | ARYL N-CYANOGUANIDINES AND METHODS RELATED THERETO | MIGENIX CORP. (US) | 2008-02-07 | — | — | US | disclosed |
| WO-2007131350-A1 | INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS REPLICATION | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2007-11-22 | — | — | WO | disclosed |
| US-20070255065-A1 | Benzodioxane and benzodioxolane derivatives and uses thereof | WYETH (US) | 2007-11-01 | — | — | US | disclosed |
| WO-2007113226-A1 | ORGANIC COMPOUNDS | NOVARTIS AG (CH) | 2007-10-11 | — | — | WO | disclosed |
| US-20070225334-A1 | Methods for treating cognitive and other disorders | WYETH (US) | 2007-09-27 | — | — | US | disclosed |
| US-7265144-B2 | Anilinopyrazole derivatives useful for the treatment of diabetes | BAYER PHARMACEUTICALS CORPORATION (US) | 2007-09-04 | — | — | US | disclosed |
| US-20070149534-A1 | PYRROLOTRIAZINE KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY | 2007-06-28 | — | — | US | disclosed |
| US-20070043095-A1 | Derivatives of 2-arylimino-2,3-dihydrothiazoles, their preparation processes and their therapeutic use | IPSEN PHARMA S.A.S. (FR) | 2007-02-22 | — | — | US | disclosed |
| US-20060241172-A1 | Benzodioxane and benzodioxolane derivatives and uses thereof | WYETH (US) | 2006-10-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (12 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210145844-A1 | COMBINATION THERAPY FOR NICOTINE ADDICTION | CHRNA2, ALDH2, ALDH1A1 | CYP3A4 630/4885HDAC3 707/4885HDAC1 298/4885 |
| US-20070225334-A1 | Methods for treating cognitive and other disorders | CHAT, COMT, ACHE | CYP3A4 1630/4885HDAC3 1569/4885HDAC1 2633/4885 |
| US-11214541-B2 | Substituted 6,7-dihydro-5H-benzo[7]annulene compounds, processes for their preparation and therapeutic uses thereof | CYP19A1, ESR1, GPER1 | CYP3A4 180/4885HDAC3 409/4885HDAC1 360/4885 |
| US-20060241172-A1 | Benzodioxane and benzodioxolane derivatives and uses thereof | HTR2C, HTR1D, HTR1A | CYP3A4 284/4885HDAC3 1862/4885HDAC1 2514/4885 |
| US-20080032981-A1 | ARYL N-CYANOGUANIDINES AND METHODS RELATED THERETO | COX5A, CA5A, COX5B | CYP3A4 244/4885HDAC3 2245/4885HDAC1 1953/4885 |
| US-20230102258-A1 | C5AR ANTAGONISTS | C5AR1, C5AR2, C3AR1 | CYP3A4 2610/4885HDAC3 2341/4885HDAC1 1943/4885 |
| US-20070043095-A1 | Derivatives of 2-arylimino-2,3-dihydrothiazoles, their preparation processes and their therapeutic use | SSTR2, SSTR5, SSTR3 | CYP3A4 973/4885HDAC3 1296/4885HDAC1 1840/4885 |
| US-20070255065-A1 | Benzodioxane and benzodioxolane derivatives and uses thereof | TBXA2R, HTR2C, NPY1R | CYP3A4 266/4885HDAC3 1721/4885HDAC1 2470/4885 |
| US-20210395243-A1 | PESTICIDAL COMPOUNDS | NIT2, PNMT, DDT | CYP3A4 476/4885HDAC3 2587/4885HDAC1 2876/4885 |
| US-20070149534-A1 | PYRROLOTRIAZINE KINASE INHIBITORS | NTRK2, NTRK3, NTRK1 | CYP3A4 3382/4885HDAC3 1205/4885HDAC1 823/4885 |
| US-20210220376-A1 | ADDICTION TREATMENT OF AN ALCOHOL-CONSUMING PATIENT POPULATION | ADH1A, ADH1C, ALDH1A1 | CYP3A4 605/4885HDAC3 1140/4885HDAC1 233/4885 |
| US-20210276960-A1 | INHIBITORS OF TISSUE TRANSGLUTAMINASE 2 (TG2) AND USES THEREOF | TGM2, TGM3, TGM6 | CYP3A4 2580/4885HDAC3 1245/4885HDAC1 440/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.