Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3A | P49840 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.37 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.37 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | PDE4A | P27815 | 5/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 5/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 5/20 | 0.36 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.36 |
| ▸ | ADORA2B | P29275 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1074421 | 0.84 | L3MBTL1 (0.46) | GSK3BL3MBTL1TDP1ADORA2BCYP3A4 | |
| SCHEMBL1074044 | 0.79 | GSK3B (0.39) | GSK3AGSK3BL3MBTL1PDE4BADORA2B | |
| SCHEMBL175529 | 0.76 | TDP1 (0.43) | GSK3BL3MBTL1TDP1PDE4AADORA2A | |
| SCHEMBL1729644 | 0.76 | ADORA2B (0.40) | L3MBTL1PDE4AADORA2APDE4BPDE4C | |
| SCHEMBL23348857 | 0.76 | L3MBTL1 (0.40) | GSK3AGSK3BL3MBTL1TDP1PDE4A | |
| SCHEMBL1746830 | 0.75 | ALDH1A1 (0.36) | PDE4APDE4BPDE4CPDE4DKDM4E | |
| SCHEMBL8318422 | 0.70 | TNF (0.36) | GSK3AGSK3BSIRT1SIRT3SIRT5 | |
| SCHEMBL174588 | 0.69 | GSK3A (0.40) | GSK3AGSK3B | |
| SCHEMBL331903 | 0.69 | PDE4A (0.47) | GSK3AGSK3BSIRT1SIRT3SIRT5 | |
| SCHEMBL1729815 | 0.69 | HTT (0.42) | GSK3AGSK3BSIRT1SIRT3SIRT5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 80 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160024108-A1 | USE OF DITHIINE-TETRACARBOXIMIDES FOR CONTROLLING BACTERIAL HARMFUL ORGANISMS IN USEFUL PLANTS | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2016-01-28 | — | — | US | claimed |
| EP-2967068-A1 | USE OF DITHIINE-TETRACARBOXIMIDES FOR CONTROLLING BACTERIAL HARMFUL ORGANISMS IN USEFUL PLANTS | Bayer CropScience Aktiengesellschaft (DE) | 2016-01-20 | — | — | EP | claimed |
| US-9221837-B2 | Process for preparing dithiine-tetracarboximides | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2015-12-29 | — | — | US | claimed |
| WO-2014139897-A1 | USE OF DITHIINE-TETRACARBOXIMIDES FOR CONTROLLING BACTERIAL HARMFUL ORGANISMS IN USEFUL PLANTS | BAYER CROPSCIENCE AG (DE) | 2014-09-18 | — | — | WO | claimed |
| US-20130316901-A1 | SYNERGISTIC COMBINATIONS CONTAINING A DITHINO-TETRACARBOXAMIDE FUNGICIDE AND A HERBICIDE, SAFENER OR PLANT GROWTH REGULATOR | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2013-11-28 | — | — | US | claimed |
| EP-2386203-B1 | Use of dithiin tetracarboximides for combating phytopathogenic fungi | BAYER CROPSCIENCE AG (DE) | 2013-11-20 | — | — | EP | claimed |
| US-8450360-B2 | Process for preparing dithiine-tetracarboximides | BAYER CROPSCIENCE AG (DE) | 2013-05-28 | — | — | US | claimed |
| EP-2454939-A1 | Post-harvest treatment | Bayer CropScience AG (DE) | 2012-05-23 | — | — | EP | claimed |
| US-20110280958-A1 | Active Compound Combinations | BAYER CROPSCIENCE AG (DE) | 2011-11-17 | — | — | US | claimed |
| US-20110269973-A1 | Process for Preparing Dithiine-tetracarboximides | BAYER CROPSCIENCE AG (DE) | 2011-11-03 | — | — | US | claimed |
| EP-2828268-B1 | METHOD FOR PRODUCING DITHIIN TETRACARBOXIMIDES | BAYER CROPSCIENCE AG (DE) | 2016-12-14 | — | — | EP | disclosed |
| US-20160286810-A1 | ACTIVE COMPOUND COMBINATIONS | BAYER CROPSCIENCE AG (DE) | 2016-10-06 | — | — | US | disclosed |
| EP-2558473-B1 | METHOD FOR PRODUCING DITHIIN TETRACARBOXIMIDES | BAYER IP GMBH (DE) | 2016-09-07 | — | — | EP | disclosed |
| US-20160024108-A1 | USE OF DITHIINE-TETRACARBOXIMIDES FOR CONTROLLING BACTERIAL HARMFUL ORGANISMS IN USEFUL PLANTS | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2016-01-28 | — | — | US | disclosed |
| EP-2967068-A1 | USE OF DITHIINE-TETRACARBOXIMIDES FOR CONTROLLING BACTERIAL HARMFUL ORGANISMS IN USEFUL PLANTS | Bayer CropScience Aktiengesellschaft (DE) | 2016-01-20 | — | — | EP | disclosed |
| US-20110118115-A1 | Active compound combinations | BAYER CROPSCIENCE AG (DE) | 2011-05-19 | — | — | US | disclosed |
| WO-2011029551-A2 | ACTIVE COMPOUND COMBINATIONS | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2011-03-17 | — | — | WO | disclosed |
| US-20110064827-A1 | Active compound combinations | BAYER CROPSCIENCE AG (DE) | 2011-03-17 | — | — | US | disclosed |
| US-20100120884-A1 | USE OF DITHIINE-TETRACARBOXIMIDES FOR CONTROLLING PHYTOPATHOGENIC FUNGI | BAYER CROPSCIENCE AG (DE) | 2010-05-13 | — | — | US | disclosed |
| WO-2010043319-A1 | USE OF DITHIIN TETRACARBOXIMIDES FOR TREATING PHYTOPATHOGENIC FUNGI | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2010-04-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110064827-A1 | Active compound combinations | TST, DPM1, DDT | GSK3A 1379/4885GSK3B 1024/4885SIRT1 513/4885 |
| US-20110118115-A1 | Active compound combinations | AADAC, ACACA, DDT | GSK3A 1921/4885GSK3B 1496/4885SIRT1 115/4885 |
| US-20110269973-A1 | Process for Preparing Dithiine-tetracarboximides | TMT1A, TST, DTYMK | GSK3A 4823/4885GSK3B 4755/4885SIRT1 3075/4885 |
| US-20160286810-A1 | ACTIVE COMPOUND COMBINATIONS | TST, DPM1, BROX | GSK3A 1182/4885GSK3B 838/4885SIRT1 364/4885 |
| US-20130316901-A1 | SYNERGISTIC COMBINATIONS CONTAINING A DITHINO-TETRACARBOXAMIDE FUNGICIDE AND A HERBICIDE, SAFENER OR PLANT GROWTH REGULATOR | DDT, ING2, DNER | GSK3A 2074/4885GSK3B 2076/4885SIRT1 1050/4885 |
| US-20100120884-A1 | USE OF DITHIINE-TETRACARBOXIMIDES FOR CONTROLLING PHYTOPATHOGENIC FUNGI | TST, TTI1, DPM1 | GSK3A 3513/4885GSK3B 3299/4885SIRT1 1985/4885 |
| US-20110280958-A1 | Active Compound Combinations | TST, QDPR, SQOR | GSK3A 987/4885GSK3B 708/4885SIRT1 343/4885 |
| US-20160024108-A1 | USE OF DITHIINE-TETRACARBOXIMIDES FOR CONTROLLING BACTERIAL HARMFUL ORGANISMS IN USEFUL PLANTS | MGAM, PGLS, DGKI | GSK3A 2133/4885GSK3B 2909/4885SIRT1 1228/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.