Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB known ✓ | P10828 | 2/20 | 0.62 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.54 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | PTPRA | P18433 | 1/20 | 0.54 |
| ▸ | PTPRB | P23467 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | MPL | P40238 | 4/20 | 0.46 |
| ▸ | CTRC | Q99895 | 2/20 | 0.46 |
| ▸ | APEX1 | P27695 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17542083 | 0.92 | CYP1A2 (0.63) | THRBPTPN1CYP1A2HIF1ACYP2C9 | |
| SCHEMBL6234639 | 0.81 | THRB (0.67) | THRBPTPN1CYP1A2HIF1ACYP2C9 | |
| SCHEMBL29366329 | 0.80 | THRB (0.65) | THRBPTPN1CYP1A2HIF1ACYP2C9 | |
| SCHEMBL3196947 | 0.79 | THRB (0.88) | THRBPTPN1CYP1A2HIF1ACYP2C9 | |
| SCHEMBL29489969 | 0.79 | THRB (0.88) | THRBPTPN1CYP1A2HIF1ACYP2C9 | |
| SCHEMBL4808237 | 0.79 | THRB (0.88) | THRBPTPN1CYP1A2HIF1ACYP2C9 | |
| E110 SCHEMBL29350765 | 0.77 | THRB (1.00) | THRBPTPN1CYP1A2HIF1ACYP2C9 | |
| E110 SCHEMBL142458 | 0.77 | THRB (1.00) | THRBPTPN1CYP1A2HIF1ACYP2C9 | |
| E110 SCHEMBL323402 | 0.77 | THRB (1.00) | THRBPTPN1CYP1A2HIF1ACYP2C9 | |
| E110 SCHEMBL13276157 | 0.77 | THRB (1.00) | THRBPTPN1CYP1A2HIF1ACYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3185850-B1 | SKIN COLOR-IMPROVING AGENT AND COMPOSITION FOR IMPROVING SKIN COLOR | SHOWA DENKO KK (JP) | 2019-10-09 | — | — | EP | disclosed |
| US-20170312301-A1 | SKIN BARRIER FUNCTION-IMPROVING AGENT AND COMPOSITION FOR IMPROVING SKIN BARRIER FUNCTION | SHOWA DENKO K.K. (JP) | 2017-11-02 | — | — | US | disclosed |
| US-20170312200-A1 | AN AGENT FOR IMPROVING MITOCHONDRIAL FUNCTION | SHOWA DENKO K.K. (JP) | 2017-11-02 | — | — | US | disclosed |
| US-20170312207-A1 | MOISTURIZING AGENT | SHOWA DENKO K.K. (JP) | 2017-11-02 | — | — | US | disclosed |
| EP-3219304-A1 | MOISTURIZING AGENT | Showa Denko K.K. (JP) | 2017-09-20 | — | — | EP | disclosed |
| EP-3213753-A1 | SKIN BARRIER FUNCTION-IMPROVING AGENT AND COMPOSITION FOR IMPROVING SKIN BARRIER FUNCTION | Showa Denko K.K. (JP) | 2017-09-06 | — | — | EP | disclosed |
| EP-3213739-A1 | AGENT FOR IMPROVING MITOCHONDRIAL FUNCTION AND ANTI-AGING COMPOSITION | Showa Denko K.K. (JP) | 2017-09-06 | — | — | EP | disclosed |
| US-20170143608-A1 | SKIN COLOR-IMPROVING AGENT AND COMPOSITION FOR IMPROVING SKIN COLOR | SHOWA DENKO K.K. (JP) | 2017-05-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170312200-A1 | AN AGENT FOR IMPROVING MITOCHONDRIAL FUNCTION | UQCRC1, ACAD9, CYP27B1 | THRB 2581/4885PTPN1 3692/4885CYP1A2 814/4885 |
| US-20170143608-A1 | SKIN COLOR-IMPROVING AGENT AND COMPOSITION FOR IMPROVING SKIN COLOR | RBP4, RBP1, RARA | THRB 2434/4885PTPN1 3428/4885CYP1A2 1028/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.