Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | CES2 | O00748 | 1/20 | 0.37 |
| ▸ | CES1 | P23141 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
| ▸ | PAX8 | Q06710 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | ATM | Q13315 | 2/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL208703 | 0.79 | KMT2A (0.39) | ALDH1A1LMNACES2CES1TDP1 | |
| SCHEMBL777046 | 0.74 | ALDH1A1 (0.50) | ALDH1A1LMNACES2CES1TDP1 | |
| SCHEMBL64436 | 0.73 | ALDH1A1 (0.63) | ALDH1A1LMNAKMT2AGAASMN1; SMN2 | |
| SCHEMBL22022744 | 0.71 | LMNA (0.47) | ALDH1A1LMNACES2CES1TDP1 | |
| SCHEMBL29255431 | 0.71 | ALDH1A1 (0.46) | ALDH1A1LMNATDP1KMT2AGAA | |
| SCHEMBL28166558 | 0.71 | ALDH1A1 (0.59) | ALDH1A1LMNAKMT2AGAASMN1; SMN2 | |
| SCHEMBL11450666 | 0.69 | NPC1 (0.53) | ALDH1A1LMNACES2CES1TDP1 | |
| SCHEMBL9312379 | 0.68 | ALDH1A1 (0.43) | ALDH1A1LMNACES2CES1TDP1 | |
| SCHEMBL180685 | 0.67 | ALDH1A1 (0.56) | ALDH1A1LMNACES2CES1TDP1 | |
| SCHEMBL3626577 | 0.67 | ALDH1A1 (0.42) | ALDH1A1LMNACES2CES1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 63 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109563045-B | Pd (II) -catalysed enantioselective beta-methylene C (sp) 3 ) -H bond activation | 斯克里普斯研究学院 | 2022-08-23 | — | — | CN | disclosed |
| CN-107162928-B | Halogenated analogs of anti-fibrotic agents | 塞尔塔医疗有限公司 | 2022-03-11 | — | — | CN | disclosed |
| US-10814013-B2 | Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2020-10-27 | — | — | US | disclosed |
| US-9265739-B2 | Methods and use of compounds that bind to HER2/neu receptor complex | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2016-02-23 | — | — | US | disclosed |
| US-9012603-B2 | Peptides that block the binding of IgG to FcRn | BIOGEN IDEC HEMOPHILIA INC. (US) | 2015-04-21 | — | — | US | disclosed |
| US-8993634-B2 | Methods and use of compounds that bind to Her2/neu receptor complex | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2015-03-31 | — | — | US | disclosed |
| US-8946259-B2 | Benzazole derivatives, compositions, and methods of use as beta-secretase inhibitors | HIGH POINT PHARMACEUTICALS, LLC (US) | 2015-02-03 | — | — | US | disclosed |
| US-8758723-B2 | Compositions and methods for cellular imaging and therapy | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2014-06-24 | — | — | US | disclosed |
| US-8703980-B2 | Process for the preparation of darunavir | TIANISH LABORATORIES PRIVATE LIMITED (IN) | 2014-04-22 | — | — | US | disclosed |
| US-20140066477-A1 | Benzazole Derivatives, Compositions, and Methods of Use as Beta-Secretase Inhibitors | HIGH POINT PHARMACEUTICALS, LLC (US) | 2014-03-06 | — | — | US | disclosed |
| US-20080119512-A1 | Carboxamide Derivatives as Therapeutic Agents | TRANSTECH PHARMA, INC. (US) | 2008-05-22 | — | — | US | disclosed |
| US-20080119454-A1 | Aryl carbonyl derivatives as therapeutic agents | NOVO NORDISK A/S (DK) | 2008-05-22 | — | — | US | disclosed |
| US-20080096942-A1 | Substituted Hydroxyethylamines | ELAN PHARMACEUTICALS, INC. | 2008-04-24 | — | — | US | disclosed |
| US-20080058336-A1 | Methods to Treat Alzheimer's Disease | ELAN PHARMACEUTICALS, INC. | 2008-03-06 | — | — | US | disclosed |
| US-20070299263-A1 | Hydroxy Alkyl Amines | Elan Pharmaceuticals, Inc. and Pharmacia & Upjohn Company | 2007-12-27 | — | — | US | disclosed |
| US-20070275910-A1 | Phosphoramidate Derivatives | UNIVERSITY COLLEGE CARDIFF CONSULTANTS LIMITED (GB) | 2007-11-29 | — | — | US | disclosed |
| US-20070254831-A1 | PEPTIDES THAT BLOCK THE BINDING OF IgG to FcRn | BIOGEN HEMOPHILIA INC. | 2007-11-01 | — | — | US | disclosed |
| US-20070248537-A1 | Compositions and Methods for Cellular Imaging and Therapy | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM | 2007-10-25 | — | — | US | disclosed |
| US-20070225374-A1 | Hydroxypropyl Amides for the Treatment of Alzheimer's Disease | ELAN PHARMACEUTICALS, INC. (US) | 2007-09-27 | — | — | US | disclosed |
| CN-1207101-A | Novel tricyclic compounds for the inhibition of the ice/ced-3 protease family of enzymes | IDUM PHARMACEUTICALS INC (US) | 1999-02-03 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (11 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080096942-A1 | Substituted Hydroxyethylamines | BACE1, BACE2, MME | ALDH1A1 2044/4885LMNA 384/4885CES2 202/4885 |
| US-10814013-B2 | Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications | TNNI3, CAD, TNNT2 | ALDH1A1 2581/4885LMNA 2077/4885CES2 3340/4885 |
| US-20070254831-A1 | PEPTIDES THAT BLOCK THE BINDING OF IgG to FcRn | FCGRT, FCGR3B, FCGR1A | ALDH1A1 4835/4885LMNA 4348/4885CES2 4815/4885 |
| US-20080058336-A1 | Methods to Treat Alzheimer's Disease | PSEN2, PSEN1, ACHE | ALDH1A1 412/4885LMNA 1749/4885CES2 64/4885 |
| US-20070299263-A1 | Hydroxy Alkyl Amines | MAOA, PSEN2, PSEN1 | ALDH1A1 597/4885LMNA 507/4885CES2 373/4885 |
| US-20070275910-A1 | Phosphoramidate Derivatives | HRH4, HRH3, NR1H4 | ALDH1A1 3963/4885LMNA 4503/4885CES2 1274/4885 |
| US-20080119512-A1 | Carboxamide Derivatives as Therapeutic Agents | AGER, S100B, S100A4 | ALDH1A1 2785/4885LMNA 373/4885CES2 2669/4885 |
| US-20070248537-A1 | Compositions and Methods for Cellular Imaging and Therapy | H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, NCL, NME4 | ALDH1A1 4432/4885LMNA 436/4885CES2 1351/4885 |
| US-20140066477-A1 | Benzazole Derivatives, Compositions, and Methods of Use as Beta-Secretase Inhibitors | BACE1, BACE2, APP | ALDH1A1 1717/4885LMNA 679/4885CES2 521/4885 |
| US-20070225374-A1 | Hydroxypropyl Amides for the Treatment of Alzheimer's Disease | BACE1, APP, BACE2 | ALDH1A1 800/4885LMNA 2005/4885CES2 707/4885 |
| US-20080119454-A1 | Aryl carbonyl derivatives as therapeutic agents | GCK, GCKR, PDK2 | ALDH1A1 192/4885LMNA 4011/4885CES2 681/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.