Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Histidine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | SLC7A5 | Q01650 | 3/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | PTPRA | P18433 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 2/20 | 0.37 |
| ▸ | ALPI | P09923 | 1/20 | 0.37 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.37 |
| ▸ | XIAP | P98170 | 1/20 | 0.37 |
| ▸ | GRIA2 | P42262 | 3/20 | 0.35 |
| ▸ | GRIA1 | P42261 | 2/20 | 0.35 |
| ▸ | GRIA3 | P42263 | 2/20 | 0.35 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | BLM | P54132 | 2/20 | 0.35 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Histidine SCHEMBL2511226 | 1.00 | CYP2C19 (0.43) | CYP2C19SLC7A5CYP3A4CYP1A2PTPRA | |
| Histidine SCHEMBL2521478 | 1.00 | CYP2C19 (0.43) | CYP2C19SLC7A5CYP3A4CYP1A2PTPRA | |
| Histidine SCHEMBL2521479 | 1.00 | CYP2C19 (0.43) | CYP2C19SLC7A5CYP3A4CYP1A2PTPRA | |
| Histidine SCHEMBL2516101 | 1.00 | CYP2C19 (0.43) | CYP2C19SLC7A5CYP3A4CYP1A2PTPRA | |
| Histidine SCHEMBL2516103 | 1.00 | CYP2C19 (0.43) | CYP2C19SLC7A5CYP3A4CYP1A2PTPRA | |
| Histidine SCHEMBL27700222 | 0.94 | SLC7A5 (0.41) | CYP2C19SLC7A5CYP3A4CYP1A2PTPRA | |
| Histidine SCHEMBL163443 | 0.91 | SLC7A5 (0.47) | SLC7A5CYP3A4CYP1A2PKMALPI | |
| Histidine SCHEMBL3259 | 0.91 | SLC7A5 (0.47) | SLC7A5CYP3A4CYP1A2PKMALPI | |
| Histidine SCHEMBL8080341 | 0.91 | SLC7A5 (0.47) | SLC7A5CYP3A4CYP1A2PKMALPI | |
| Histidine SCHEMBL388563 | 0.91 | SLC7A5 (0.47) | SLC7A5CYP3A4CYP1A2PKMALPI |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 64 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12448357-B1 | Amino acid compositions | THERMOLIFE INTERNATIONAL, LLC (US) | 2025-10-21 | — | — | US | claimed |
| US-12240819-B1 | Amino acid compositions | THERMOLIFE INTERNATIONAL, LLC (US) | 2025-03-04 | — | — | US | claimed |
| US-11155524-B2 | Amino acid compositions | THERMOLIFE INTERNATIONAL, LLC (US) | 2021-10-26 | — | — | US | claimed |
| US-20200297678-A1 | Amino Acid Compositions | THERMOLIFE INTERNATIONAL, LLC | 2020-09-24 | — | — | US | claimed |
| CN-102850276-A | Histidine nitrate preparation method | TIANJIN TIANCHENG PHARMACEUTICAL CO LTD | 2013-01-02 | — | — | CN | claimed |
| US-12612370-B2 | Amino acid compositions | THERMOLIFE INTERNATIONAL, LLC (US) | 2026-04-28 | — | — | US | disclosed |
| US-12577209-B2 | Amino acid compositions | THERMOLIFE INTERNATIONAL, LLC (US) | 2026-03-17 | — | — | US | disclosed |
| US-12577210-B2 | Amino acid compositions | THERMOLIFE INTERNATIONAL, LLC (US) | 2026-03-17 | — | — | US | disclosed |
| US-12540119-B2 | Amino acid compositions | THERMOLIFE INTERNATIONAL, LLC (US) | 2026-02-03 | — | — | US | disclosed |
| US-12522568-B2 | Amino acid compositions | THERMOLIFE INTERNATIONAL, LLC (US) | 2026-01-13 | — | — | US | disclosed |
| US-12473261-B2 | Amino acid compositions | THERMOLIFE INTERNATIONAL, LLC (US) | 2025-11-18 | — | — | US | disclosed |
| US-12448357-B1 | Amino acid compositions | THERMOLIFE INTERNATIONAL, LLC (US) | 2025-10-21 | — | — | US | disclosed |
| US-8178572-B2 | Amino acid compounds | THERMOLIFE INTERNATIONAL, LLC (US) | 2012-05-15 | — | — | US | disclosed |
| US-20110313043-A1 | Amino Acid Compositions | THERMOLIFE INTERNATIONAL, LLC (US) | 2011-12-22 | — | — | US | disclosed |
| US-8034836-B2 | Amino acid compounds | THERMOLIFE INTERNATIONAL, LLC (US) | 2011-10-11 | — | — | US | disclosed |
| US-7777074-B2 | Amino acid compounds | THERMOLIFE INTERNATIONAL, LLC (US) | 2010-08-17 | — | — | US | disclosed |
| US-20090105328-A1 | Amino Acid Compounds | THERMOLIFE INTERNATIONAL, LLC | 2009-04-23 | — | — | US | disclosed |
| US-20090076110-A1 | Amino Acid Compounds | THERMOLIFE INTERNATIONAL, LLC | 2009-03-19 | — | — | US | disclosed |
| CN-101235100-A | Method for cleanly preparing acylchitosan | UNIV QINGDAO SCIENCE & TECHNOLOGY (CN) | 2008-08-06 | — | — | CN | disclosed |
| CN-1631539-A | Amino acid salt ion liquid and its preparation | UNIV BEIJING (CN) | 2005-06-29 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (12 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12473261-B2 | Amino acid compositions | ASNS, GLUL, ARGLU1 | CYP2C19 1156/4885SLC7A5 13/4885CYP3A4 1179/4885 |
| US-12612370-B2 | Amino acid compositions | TNNT2, NPR1, NOS2 | CYP2C19 691/4885SLC7A5 51/4885CYP3A4 1657/4885 |
| US-12448357-B1 | Amino acid compositions | SLC6A15, SLC1A5, SLC6A19 | CYP2C19 233/4885SLC7A5 13/4885CYP3A4 635/4885 |
| US-12540119-B2 | Amino acid compositions | NOS2, NOS1, NOS3 | CYP2C19 553/4885SLC7A5 26/4885CYP3A4 1293/4885 |
| US-20090076110-A1 | Amino Acid Compounds | OAT, ARGLU1, ASNS | CYP2C19 939/4885SLC7A5 46/4885CYP3A4 760/4885 |
| US-12240819-B1 | Amino acid compositions | SLC10A2, SLC1A5, CPT1B | CYP2C19 451/4885SLC7A5 10/4885CYP3A4 538/4885 |
| US-12577209-B2 | Amino acid compositions | ARG1, NOS1, NOS2 | CYP2C19 502/4885SLC7A5 27/4885CYP3A4 1377/4885 |
| US-20090105328-A1 | Amino Acid Compounds | DNPEP, AADAT, ASNS | CYP2C19 1998/4885SLC7A5 27/4885CYP3A4 2870/4885 |
| US-12577210-B2 | Amino acid compositions | NPR1, SLC1A5, SLC6A15 | CYP2C19 493/4885SLC7A5 14/4885CYP3A4 1575/4885 |
| US-20110313043-A1 | Amino Acid Compositions | ARGLU1, AADAT, MUSK | CYP2C19 1293/4885SLC7A5 31/4885CYP3A4 1704/4885 |
| US-20200297678-A1 | Amino Acid Compositions | ASNS, ARGLU1, SLC6A15 | CYP2C19 1743/4885SLC7A5 27/4885CYP3A4 1881/4885 |
| US-11155524-B2 | Amino acid compositions | ASNS, ARGLU1, SLC6A15 | CYP2C19 1743/4885SLC7A5 27/4885CYP3A4 1881/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.