SCHEMBL2516448

SCHEMBL2516448

Oc1cc(/C=C/c2ccc(Oc3ccccc3)cc2)cc(Oc2ccccc2)c1

nearest known ligand 0.62

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 4/20 0.62
MEN1 O00255 4/20 0.62
ALDH1A1 P00352 4/20 0.62
KMT2A Q03164 4/20 0.62
TP53 P04637 3/20 0.62
CYP3A4 P08684 3/20 0.62
MAPT P10636 3/20 0.62
HPGD P15428 3/20 0.62
SMN1; SMN2 Q16637 3/20 0.62
HSD17B10 Q99714 3/20 0.62
USP2 O75604 2/20 0.62
TRPV1 Q8NER1 1/20 0.62
CYP1A1 P04798 4/20 0.58
CYP1A2 P05177 3/20 0.58
CYP19A1 P11511 2/20 0.58
PTGS2 P35354 4/20 0.54
CYP1B1 Q16678 3/20 0.54
TTR P02766 2/20 0.54
ALOX5 P09917 2/20 0.54
LTA4H P09960 2/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2516451 1.00 KDM4E (0.62) KDM4EMEN1ALDH1A1KMT2ATP53
SCHEMBL2513437 0.95 CYP1A1 (0.65) KDM4EMEN1ALDH1A1KMT2ATP53
SCHEMBL2513436 0.95 CYP1A1 (0.65) KDM4EMEN1ALDH1A1KMT2ATP53
SCHEMBL2516476 0.93 KDM4E (0.61) KDM4EMEN1ALDH1A1KMT2ATP53
SCHEMBL2516475 0.93 KDM4E (0.61) KDM4EMEN1ALDH1A1KMT2ATP53
SCHEMBL2521181 0.89 CYP1A1 (0.61) KDM4EMEN1ALDH1A1KMT2ATP53
SCHEMBL2521178 0.89 CYP1A1 (0.61) KDM4EMEN1ALDH1A1KMT2ATP53
SCHEMBL2516557 0.89 ESR1 (0.53) KDM4EMEN1ALDH1A1KMT2ATP53
SCHEMBL31322155 0.85 PTGS2 (0.61) KDM4EMEN1ALDH1A1KMT2ATP53
SCHEMBL28524463 0.85 PTGS1 (0.71) KDM4EMEN1ALDH1A1KMT2ATP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9861564-B2 Valeric acid esters of resveratrol and cosmetic compositions ELC MANAGEMENT, LLC (US) 2018-01-09 US disclosed
US-9782335-B2 Malic acid esters of resveratrol and cosmetic compositions ELC MANAGEMENT LLC (US) 2017-10-10 US disclosed
US-20160303016-A1 Valeric Acid Esters Of Resveratrol And Cosmetic Compositions ELC MAN LLC (US) 2016-10-20 US disclosed
EP-2445511-B1 SKIN REPAIR COMPOSITIONS COMPRISING CIRCADIAN GENE ACTIVATORS AND A SYNERGISTIC COMBINATION OF SIRT1 GENE ACTIVATORS ELC MAN LLC (US) 2016-09-07 EP disclosed
US-20160229791-A1 Malic Acid Esters Of Resveratrol And Cosmetic Compositions ELC MAN LLC (US) 2016-08-11 US disclosed
US-9358194-B2 Succinic acid esters of resveratrol and cosmetic compositions ELC MANAGEMENT LLC (US) 2016-06-07 US disclosed
US-9295621-B2 Emulsion cosmetic compositions containing resveratrol derivatives and silicone surfactant ELC MANAGEMENT LLC (US) 2016-03-29 US disclosed
US-20160038389-A1 Succinic Acid Esters Of Resveratrol And Cosmetic Compositions ELC MAN LLC (US) 2016-02-11 US disclosed
US-9180316-B2 Butyric acid esters of resveratrol and cosmetic compositions ELC MANAGEMENT LLC (US) 2015-11-10 US disclosed
US-9162083-B2 Linoleic and Linolenic acid esters of resveratrol and cosmetic compositions ELC MANAGEMENT LLC (US) 2015-10-20 US disclosed
EP-2185128-A1 COSMETIC COMPOSITIONS CONTAINING RESVERATROL DERIVATIVES ELC Management LLC (US) 2010-05-19 EP disclosed
US-20100080845-A1 Cosmetic Methods And Compositions For Repairing Human Skin MAES DANIEL H 2010-04-01 US disclosed
US-20100028317-A1 Skin Repair Compositions Comprising Circadian Gene Activators And A Synergistic Combination Of Sirt1 Gene Activators ELC MANAGEMENT LLC 2010-02-04 US disclosed
US-20090047309-A1 COSMETIC METHODS AND COMPOSITIONS FOR REPAIRING HUMAN SKIN ELC MANAGEMENT LLC 2009-02-19 US disclosed
US-20090035243-A1 Anhydrous Cosmetic Compositions Containing Resveratrol Derivatives ELC MANAGEMENT LLC 2009-02-05 US disclosed
US-20090035240-A1 Aqueous Based Cosmetic Compositions Containing Resveratrol Derivatives And An Aqueous Phase Structuring Agent ELC MANAGEMENT LLC 2009-02-05 US disclosed
US-20090035242-A1 Emulsion Cosmetic Compositions Containing Resveratrol Derivatives And Linear Or Branched Silicone ELC MANAGEMENT LLC 2009-02-05 US disclosed
US-20090035236-A1 Emulsion Cosmetic Compositions Containing Resveratrol Derivatives And An Oil Phase Structuring Agent ELC MANAGEMENT LLC 2009-02-05 US disclosed
WO-2009017866-A1 COSMETIC COMPOSITIONS CONTAINING RESVERATROL DERIVATIVES ELC MANAGEMENT LLC (US) 2009-02-05 WO disclosed
US-20090035237-A1 Emulsion Cosmetic Compositions Containing Resveratrol Derivatives And Silicone Surfactant ELC MANAGEMENT LLC 2009-02-05 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (11 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090035243-A1 Anhydrous Cosmetic Compositions Containing Resveratrol Derivatives RB1, SIRT1, EP300 KDM4E 506/4885MEN1 3365/4885ALDH1A1 608/4885
US-20090035242-A1 Emulsion Cosmetic Compositions Containing Resveratrol Derivatives And Linear Or Branched Silicone SQLE, SMURF1, PIK3R1 KDM4E 1188/4885MEN1 2323/4885ALDH1A1 3102/4885
US-20090047309-A1 COSMETIC METHODS AND COMPOSITIONS FOR REPAIRING HUMAN SKIN CUTA, ERCC1, OGG1 KDM4E 1584/4885MEN1 2434/4885ALDH1A1 527/4885
US-20100028317-A1 Skin Repair Compositions Comprising Circadian Gene Activators And A Synergistic Combination Of Sirt1 Gene Activators CRY1, PER2, SIRT1 KDM4E 583/4885MEN1 1609/4885ALDH1A1 2290/4885
US-20160303016-A1 Valeric Acid Esters Of Resveratrol And Cosmetic Compositions CUTA, SUV39H1, RARA KDM4E 450/4885MEN1 1277/4885ALDH1A1 717/4885
US-20090035237-A1 Emulsion Cosmetic Compositions Containing Resveratrol Derivatives And Silicone Surfactant SMURF1, CUTA, SMURF2 KDM4E 1074/4885MEN1 2619/4885ALDH1A1 3004/4885
US-20090035236-A1 Emulsion Cosmetic Compositions Containing Resveratrol Derivatives And An Oil Phase Structuring Agent CUTA, LRAT, RARA KDM4E 1813/4885MEN1 2973/4885ALDH1A1 2717/4885
US-20090035240-A1 Aqueous Based Cosmetic Compositions Containing Resveratrol Derivatives And An Aqueous Phase Structuring Agent SMARCC1, RARG, RARA KDM4E 2286/4885MEN1 1807/4885ALDH1A1 2613/4885
US-20100080845-A1 Cosmetic Methods And Compositions For Repairing Human Skin CUTA, ERCC1, OGG1 KDM4E 1584/4885MEN1 2434/4885ALDH1A1 527/4885
US-20160229791-A1 Malic Acid Esters Of Resveratrol And Cosmetic Compositions ME1, ME2, ME3 KDM4E 421/4885MEN1 925/4885ALDH1A1 295/4885
US-20160038389-A1 Succinic Acid Esters Of Resveratrol And Cosmetic Compositions SUCNR1, SIRT1, SUCLA2 KDM4E 368/4885MEN1 2813/4885ALDH1A1 588/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.