SCHEMBL2521983

SCHEMBL2521983

N=C(N)c1ccc(C=Cc2cc(C(=N)N)cc(C(=N)N)c2)cc1

nearest known ligand 0.79

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PRMT1 Q99873 3/20 0.79
PRMT5 O14744 1/20 0.79
ALDH1A1 P00352 1/20 0.79
HPGD P15428 1/20 0.79
CYP2C19 P33261 1/20 0.79
HSD17B10 Q99714 1/20 0.79
PLAU P00749 5/20 0.54
PLG P00747 2/20 0.54
PLAT P00750 2/20 0.54
KLK1 P06870 2/20 0.54
KDM4E B2RXH2 1/20 0.49
POLB P06746 1/20 0.49
MAPT P10636 1/20 0.49
RAD52 P43351 1/20 0.49
UBE2N P61088 1/20 0.49
NPSR1 Q6W5P4 1/20 0.49
F2 P00734 9/20 0.49
F10 P00742 8/20 0.49
NQO2 P16083 1/20 0.47
LMNA P02545 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Stilbamidine SCHEMBL208655 0.89 PRMT1 (1.00) PRMT1PRMT5ALDH1A1HPGDCYP2C19
Stilbamidine SCHEMBL889782 0.89 PRMT1 (1.00) PRMT1PRMT5ALDH1A1HPGDCYP2C19
SCHEMBL2517134 0.89 ALDH1A1 (0.68) PRMT1PRMT5ALDH1A1HPGDCYP2C19
SCHEMBL2517133 0.89 ALDH1A1 (0.68) PRMT1PRMT5ALDH1A1HPGDCYP2C19
SCHEMBL2521141 0.88 ALDH1A1 (0.61) PRMT1PRMT5ALDH1A1HPGDCYP2C19
SCHEMBL2521139 0.88 ALDH1A1 (0.61) PRMT1PRMT5ALDH1A1HPGDCYP2C19
Stilbamidine SCHEMBL3932459 0.87 PRMT1 (0.95) PRMT1PRMT5ALDH1A1HPGDCYP2C19
Stilbamidine SCHEMBL871695 0.85 PRMT1 (0.91) PRMT1PRMT5ALDH1A1HPGDCYP2C19
SCHEMBL2520060 0.84 ALDH1A1 (0.73) PRMT1PRMT5ALDH1A1HPGDCYP2C19
SCHEMBL2520059 0.84 ALDH1A1 (0.73) PRMT1PRMT5ALDH1A1HPGDCYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9861564-B2 Valeric acid esters of resveratrol and cosmetic compositions ELC MANAGEMENT, LLC (US) 2018-01-09 US disclosed
US-9782335-B2 Malic acid esters of resveratrol and cosmetic compositions ELC MANAGEMENT LLC (US) 2017-10-10 US disclosed
US-20160303016-A1 Valeric Acid Esters Of Resveratrol And Cosmetic Compositions ELC MAN LLC (US) 2016-10-20 US disclosed
EP-2445511-B1 SKIN REPAIR COMPOSITIONS COMPRISING CIRCADIAN GENE ACTIVATORS AND A SYNERGISTIC COMBINATION OF SIRT1 GENE ACTIVATORS ELC MAN LLC (US) 2016-09-07 EP disclosed
US-20160229791-A1 Malic Acid Esters Of Resveratrol And Cosmetic Compositions ELC MAN LLC (US) 2016-08-11 US disclosed
US-9358194-B2 Succinic acid esters of resveratrol and cosmetic compositions ELC MANAGEMENT LLC (US) 2016-06-07 US disclosed
US-9295621-B2 Emulsion cosmetic compositions containing resveratrol derivatives and silicone surfactant ELC MANAGEMENT LLC (US) 2016-03-29 US disclosed
US-20160038389-A1 Succinic Acid Esters Of Resveratrol And Cosmetic Compositions ELC MAN LLC (US) 2016-02-11 US disclosed
US-9180316-B2 Butyric acid esters of resveratrol and cosmetic compositions ELC MANAGEMENT LLC (US) 2015-11-10 US disclosed
US-9162083-B2 Linoleic and Linolenic acid esters of resveratrol and cosmetic compositions ELC MANAGEMENT LLC (US) 2015-10-20 US disclosed
EP-2185128-A1 COSMETIC COMPOSITIONS CONTAINING RESVERATROL DERIVATIVES ELC Management LLC (US) 2010-05-19 EP disclosed
US-20100080845-A1 Cosmetic Methods And Compositions For Repairing Human Skin MAES DANIEL H 2010-04-01 US disclosed
US-20100028317-A1 Skin Repair Compositions Comprising Circadian Gene Activators And A Synergistic Combination Of Sirt1 Gene Activators ELC MANAGEMENT LLC 2010-02-04 US disclosed
US-20090047309-A1 COSMETIC METHODS AND COMPOSITIONS FOR REPAIRING HUMAN SKIN ELC MANAGEMENT LLC 2009-02-19 US disclosed
US-20090035243-A1 Anhydrous Cosmetic Compositions Containing Resveratrol Derivatives ELC MANAGEMENT LLC 2009-02-05 US disclosed
US-20090035240-A1 Aqueous Based Cosmetic Compositions Containing Resveratrol Derivatives And An Aqueous Phase Structuring Agent ELC MANAGEMENT LLC 2009-02-05 US disclosed
US-20090035242-A1 Emulsion Cosmetic Compositions Containing Resveratrol Derivatives And Linear Or Branched Silicone ELC MANAGEMENT LLC 2009-02-05 US disclosed
WO-2009017866-A1 COSMETIC COMPOSITIONS CONTAINING RESVERATROL DERIVATIVES ELC MANAGEMENT LLC (US) 2009-02-05 WO disclosed
US-20090035237-A1 Emulsion Cosmetic Compositions Containing Resveratrol Derivatives And Silicone Surfactant ELC MANAGEMENT LLC 2009-02-05 US disclosed
US-20090035236-A1 Emulsion Cosmetic Compositions Containing Resveratrol Derivatives And An Oil Phase Structuring Agent ELC MANAGEMENT LLC 2009-02-05 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (11 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090035243-A1 Anhydrous Cosmetic Compositions Containing Resveratrol Derivatives RB1, SIRT1, EP300 PRMT1 1104/4885PRMT5 1488/4885ALDH1A1 608/4885
US-20090035242-A1 Emulsion Cosmetic Compositions Containing Resveratrol Derivatives And Linear Or Branched Silicone SQLE, SMURF1, PIK3R1 PRMT1 787/4885PRMT5 1101/4885ALDH1A1 3102/4885
US-20090047309-A1 COSMETIC METHODS AND COMPOSITIONS FOR REPAIRING HUMAN SKIN CUTA, ERCC1, OGG1 PRMT1 264/4885PRMT5 343/4885ALDH1A1 527/4885
US-20100028317-A1 Skin Repair Compositions Comprising Circadian Gene Activators And A Synergistic Combination Of Sirt1 Gene Activators CRY1, PER2, SIRT1 PRMT1 69/4885PRMT5 822/4885ALDH1A1 2290/4885
US-20160303016-A1 Valeric Acid Esters Of Resveratrol And Cosmetic Compositions CUTA, SUV39H1, RARA PRMT1 1486/4885PRMT5 1778/4885ALDH1A1 717/4885
US-20090035237-A1 Emulsion Cosmetic Compositions Containing Resveratrol Derivatives And Silicone Surfactant SMURF1, CUTA, SMURF2 PRMT1 1048/4885PRMT5 1614/4885ALDH1A1 3004/4885
US-20090035236-A1 Emulsion Cosmetic Compositions Containing Resveratrol Derivatives And An Oil Phase Structuring Agent CUTA, LRAT, RARA PRMT1 1619/4885PRMT5 2571/4885ALDH1A1 2717/4885
US-20090035240-A1 Aqueous Based Cosmetic Compositions Containing Resveratrol Derivatives And An Aqueous Phase Structuring Agent SMARCC1, RARG, RARA PRMT1 335/4885PRMT5 852/4885ALDH1A1 2613/4885
US-20100080845-A1 Cosmetic Methods And Compositions For Repairing Human Skin CUTA, ERCC1, OGG1 PRMT1 264/4885PRMT5 343/4885ALDH1A1 527/4885
US-20160229791-A1 Malic Acid Esters Of Resveratrol And Cosmetic Compositions ME1, ME2, ME3 PRMT1 1684/4885PRMT5 2172/4885ALDH1A1 295/4885
US-20160038389-A1 Succinic Acid Esters Of Resveratrol And Cosmetic Compositions SUCNR1, SIRT1, SUCLA2 PRMT1 1368/4885PRMT5 1594/4885ALDH1A1 588/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.