SCHEMBL2521141

SCHEMBL2521141

N=C(N)c1cc(C=Cc2ccc(O)cc2)cc(C(=N)N)c1

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.61
HPGD P15428 3/20 0.61
CYP2C19 P33261 3/20 0.61
HSD17B10 Q99714 3/20 0.61
PRMT5 O14744 1/20 0.61
PRMT1 Q99873 1/20 0.61
LMNA P02545 3/20 0.55
APP P05067 3/20 0.55
KDM4E B2RXH2 3/20 0.55
MEN1 O00255 3/20 0.55
MAPT P10636 3/20 0.55
KMT2A Q03164 3/20 0.55
KDM1A O60341 3/20 0.55
PTGS1 P23219 3/20 0.55
NQO2 P16083 3/20 0.55
TTR P02766 3/20 0.55
CA12 O43570 2/20 0.55
CA1 P00915 2/20 0.55
CA2 P00918 2/20 0.55
CA3 P07451 2/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2521139 1.00 ALDH1A1 (0.61) ALDH1A1HPGDCYP2C19HSD17B10PRMT5
SCHEMBL2519130 0.93 PTGS1 (0.62) ALDH1A1HPGDCYP2C19HSD17B10PRMT5
SCHEMBL2519127 0.93 PTGS1 (0.62) ALDH1A1HPGDCYP2C19HSD17B10PRMT5
SCHEMBL2521983 0.88 PRMT1 (0.79) ALDH1A1HPGDCYP2C19HSD17B10PRMT5
SCHEMBL2517133 0.85 ALDH1A1 (0.68) ALDH1A1HPGDCYP2C19HSD17B10PRMT5
SCHEMBL2517134 0.85 ALDH1A1 (0.68) ALDH1A1HPGDCYP2C19HSD17B10PRMT5
SCHEMBL2520060 0.81 ALDH1A1 (0.73) ALDH1A1HPGDCYP2C19HSD17B10PRMT5
SCHEMBL2520059 0.81 ALDH1A1 (0.73) ALDH1A1HPGDCYP2C19HSD17B10PRMT5
Stilbamidine SCHEMBL889782 0.77 PRMT1 (1.00) ALDH1A1HPGDCYP2C19HSD17B10PRMT5
Stilbamidine SCHEMBL208655 0.77 PRMT1 (1.00) ALDH1A1HPGDCYP2C19HSD17B10PRMT5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9861564-B2 Valeric acid esters of resveratrol and cosmetic compositions ELC MANAGEMENT, LLC (US) 2018-01-09 US disclosed
US-9782335-B2 Malic acid esters of resveratrol and cosmetic compositions ELC MANAGEMENT LLC (US) 2017-10-10 US disclosed
US-20160303016-A1 Valeric Acid Esters Of Resveratrol And Cosmetic Compositions ELC MAN LLC (US) 2016-10-20 US disclosed
EP-2445511-B1 SKIN REPAIR COMPOSITIONS COMPRISING CIRCADIAN GENE ACTIVATORS AND A SYNERGISTIC COMBINATION OF SIRT1 GENE ACTIVATORS ELC MAN LLC (US) 2016-09-07 EP disclosed
US-20160229791-A1 Malic Acid Esters Of Resveratrol And Cosmetic Compositions ELC MAN LLC (US) 2016-08-11 US disclosed
US-9358194-B2 Succinic acid esters of resveratrol and cosmetic compositions ELC MANAGEMENT LLC (US) 2016-06-07 US disclosed
US-9295621-B2 Emulsion cosmetic compositions containing resveratrol derivatives and silicone surfactant ELC MANAGEMENT LLC (US) 2016-03-29 US disclosed
US-20160038389-A1 Succinic Acid Esters Of Resveratrol And Cosmetic Compositions ELC MAN LLC (US) 2016-02-11 US disclosed
US-9180316-B2 Butyric acid esters of resveratrol and cosmetic compositions ELC MANAGEMENT LLC (US) 2015-11-10 US disclosed
US-9162083-B2 Linoleic and Linolenic acid esters of resveratrol and cosmetic compositions ELC MANAGEMENT LLC (US) 2015-10-20 US disclosed
US-20110250251-A1 Cosmetic Methods And Compositions For Repairing Human Skin MAES DANIEL H 2011-10-13 US disclosed
US-20100216879-A1 Resveratrol Ferulate Compounds And Compositions MAES DANIEL H 2010-08-26 US disclosed
US-20100080845-A1 Cosmetic Methods And Compositions For Repairing Human Skin MAES DANIEL H 2010-04-01 US disclosed
US-20100028317-A1 Skin Repair Compositions Comprising Circadian Gene Activators And A Synergistic Combination Of Sirt1 Gene Activators ELC MANAGEMENT LLC 2010-02-04 US disclosed
US-20090047309-A1 COSMETIC METHODS AND COMPOSITIONS FOR REPAIRING HUMAN SKIN ELC MANAGEMENT LLC 2009-02-19 US disclosed
US-20090035243-A1 Anhydrous Cosmetic Compositions Containing Resveratrol Derivatives ELC MANAGEMENT LLC 2009-02-05 US disclosed
US-20090035240-A1 Aqueous Based Cosmetic Compositions Containing Resveratrol Derivatives And An Aqueous Phase Structuring Agent ELC MANAGEMENT LLC 2009-02-05 US disclosed
US-20090035242-A1 Emulsion Cosmetic Compositions Containing Resveratrol Derivatives And Linear Or Branched Silicone ELC MANAGEMENT LLC 2009-02-05 US disclosed
US-20090035236-A1 Emulsion Cosmetic Compositions Containing Resveratrol Derivatives And An Oil Phase Structuring Agent ELC MANAGEMENT LLC 2009-02-05 US disclosed
US-20090035237-A1 Emulsion Cosmetic Compositions Containing Resveratrol Derivatives And Silicone Surfactant ELC MANAGEMENT LLC 2009-02-05 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (13 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090035243-A1 Anhydrous Cosmetic Compositions Containing Resveratrol Derivatives RB1, SIRT1, EP300 ALDH1A1 608/4885HPGD 310/4885CYP2C19 1695/4885
US-20090035242-A1 Emulsion Cosmetic Compositions Containing Resveratrol Derivatives And Linear Or Branched Silicone SQLE, SMURF1, PIK3R1 ALDH1A1 3102/4885HPGD 1849/4885CYP2C19 3035/4885
US-20100216879-A1 Resveratrol Ferulate Compounds And Compositions FER, FOLR1, FOLR2 ALDH1A1 1726/4885HPGD 1424/4885CYP2C19 800/4885
US-20090047309-A1 COSMETIC METHODS AND COMPOSITIONS FOR REPAIRING HUMAN SKIN CUTA, ERCC1, OGG1 ALDH1A1 527/4885HPGD 199/4885CYP2C19 1005/4885
US-20100028317-A1 Skin Repair Compositions Comprising Circadian Gene Activators And A Synergistic Combination Of Sirt1 Gene Activators CRY1, PER2, SIRT1 ALDH1A1 2290/4885HPGD 2617/4885CYP2C19 4172/4885
US-20110250251-A1 Cosmetic Methods And Compositions For Repairing Human Skin CUTA, ERCC1, OGG1 ALDH1A1 527/4885HPGD 199/4885CYP2C19 1005/4885
US-20160303016-A1 Valeric Acid Esters Of Resveratrol And Cosmetic Compositions CUTA, SUV39H1, RARA ALDH1A1 717/4885HPGD 816/4885CYP2C19 385/4885
US-20090035237-A1 Emulsion Cosmetic Compositions Containing Resveratrol Derivatives And Silicone Surfactant SMURF1, CUTA, SMURF2 ALDH1A1 3004/4885HPGD 2286/4885CYP2C19 2767/4885
US-20090035236-A1 Emulsion Cosmetic Compositions Containing Resveratrol Derivatives And An Oil Phase Structuring Agent CUTA, LRAT, RARA ALDH1A1 2717/4885HPGD 1446/4885CYP2C19 2349/4885
US-20090035240-A1 Aqueous Based Cosmetic Compositions Containing Resveratrol Derivatives And An Aqueous Phase Structuring Agent SMARCC1, RARG, RARA ALDH1A1 2613/4885HPGD 599/4885CYP2C19 3192/4885
US-20100080845-A1 Cosmetic Methods And Compositions For Repairing Human Skin CUTA, ERCC1, OGG1 ALDH1A1 527/4885HPGD 199/4885CYP2C19 1005/4885
US-20160229791-A1 Malic Acid Esters Of Resveratrol And Cosmetic Compositions ME1, ME2, ME3 ALDH1A1 295/4885HPGD 453/4885CYP2C19 689/4885
US-20160038389-A1 Succinic Acid Esters Of Resveratrol And Cosmetic Compositions SUCNR1, SIRT1, SUCLA2 ALDH1A1 588/4885HPGD 279/4885CYP2C19 783/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.