SCHEMBL2632322

SCHEMBL2632322

N#Cc1ccc(N(C2=NC3=NC(N(c4ccc(C#N)cc4)c4ccc(C#N)cc4)=NC4=NC(N(c5ccc(C#N)cc5)c5ccc(C#N)cc5)=NC(=N2)N34)c2ccc(C#N)cc2)cc1

nearest known ligand 0.34

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
CYP2A6 P11509 2/20 0.34
ENPP2 Q13822 1/20 0.34
CYP19A1 P11511 14/20 0.33
ALDH1A1 P00352 1/20 0.33
CA12 O43570 1/20 0.33
CA2 P00918 1/20 0.33
CA3 P07451 1/20 0.33
CA6 P23280 1/20 0.33
CA9 Q16790 1/20 0.33
CA14 Q9ULX7 1/20 0.33
CYP11B2 P19099 3/20 0.33
CYP11B1 P15538 2/20 0.33
ELANE P08246 1/20 0.33
CYP3A4 P08684 1/20 0.33
TSHR P16473 1/20 0.33
CYP2C19 P33261 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2632320 0.94 TSHR (0.39) CYP19A1CYP11B2CYP11B1TSHR
SCHEMBL2623746 0.88
SCHEMBL2632415 0.88 KIF11 (0.49) CYP19A1CYP3A4
SCHEMBL2623745 0.84 ABCG2 (0.32) TSHR
SCHEMBL2623748 0.76 RORC (0.37) CYP2A6CYP19A1ALDH1A1ELANECYP3A4
SCHEMBL2623732 0.76 ALDH1A1 (0.38) ALDH1A1ELANETSHR
SCHEMBL2623728 0.75 L3MBTL1 (0.37) ALDH1A1CYP3A4TSHRCYP2C19
SCHEMBL995812 0.73 CA2 (0.50) CYP2A6ENPP2ALDH1A1CA12CA2
SCHEMBL8330253 0.68 CYP19A1 (0.52) CYP2A6ENPP2CYP19A1ALDH1A1CA12
SCHEMBL25544161 0.68 MMP3 (0.56) CYP2A6ENPP2ALDH1A1CA12CA2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20120091884-A1 HEPTAAZAPHENALENE DERIVATIVES AND USE THEREOF IN ORGANIC ELECTROLUMINESCENT DEVICE COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION (AT) 2012-04-19 US disclosed
WO-2010132953-A1 HEPTAAZAPHENALENE DERIVATIVES AND USE THEREOF IN ORGANIC ELECTROLUMINESCENT DEVICE COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION (AU) 2010-11-25 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120091884-A1 HEPTAAZAPHENALENE DERIVATIVES AND USE THEREOF IN ORGANIC ELECTROLUMINESCENT DEVICE HSD17B2, CYP1A2, HSD17B1 CYP2A6 203/4885ENPP2 750/4885CYP19A1 30/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.