Rotigaptide

Rotigaptide

SCHEMBL29359046

CC(=O)N[C@H](Cc1ccc(O)cc1)C(=O)N1CCC[C@@H]1C(=O)N1C[C@@H](O)C[C@@H]1C(=O)NCC(=O)N[C@H](C)C(=O)NCC(N)=O

nearest known ligand 0.50

Full drug profile on Sugi Atlas →

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
▸ VHL P40337 1/20 0.49
▸ OPRD1 P41143 4/20 0.45
▸ OPRM1 P35372 2/20 0.45
▸ BDKRB2 P30411 2/20 0.44
▸ NMUR2 Q9GZQ4 1/20 0.43
▸ NMUR1 Q9HB89 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Rotigaptide SCHEMBL20547994 1.00 VHL (0.49) VHLOPRD1OPRM1BDKRB2NMUR2
Rotigaptide SCHEMBL20547993 1.00 VHL (0.49) VHLOPRD1OPRM1BDKRB2NMUR2
SCHEMBL19381802 0.94 VHL (0.47) VHLOPRD1OPRM1BDKRB2
SCHEMBL16925996 0.94 VHL (0.47) VHLOPRD1OPRM1BDKRB2
SCHEMBL20626228 0.93 VHL (0.52) VHLOPRD1OPRM1BDKRB2NMUR2
SCHEMBL31327461 0.86 VHL (0.54) VHLOPRD1OPRM1BDKRB2
SCHEMBL20782464 0.80 F2 (0.37) VHLOPRD1OPRM1
SCHEMBL10624291 0.79 VHL (0.42) VHLOPRD1BDKRB2
SCHEMBL19381804 0.78 VHL (0.51) VHLOPRD1OPRM1
SCHEMBL16925966 0.77 VHL (0.52) VHLOPRD1OPRM1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 198 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11324799-B2 Gap junction intercellular communication modulators and their use for the treatment of diabetic eye disease ZEALAND PHARMA A/S (DK) 2022-05-10 — — US claimed
EP-4739309-A1 DANEGAPTIDE FOR USE IN TREATING SYNUCLEINOPATHIES Cambridge Enterprise Limited (GB) 2026-05-13 — — EP disclosed
EP-4739352-A1 HUMAN THERAPY UTILIZING NOVEL PROKARYOTIC VOLTAGE GATED SODIUM CHANNELS Duke University (US) 2026-05-13 — — EP disclosed
US-12624002-B2 Dimers for use in synthesis of peptidomimetics THE FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH (US) 2026-05-12 — — US disclosed
EP-2841109-B1 PRODRUGS OF HYDROXYL-COMPRISING DRUGS ASCENDIS PHARMA AS (DK) 2026-04-15 — — EP disclosed
US-12600699-B2 Thiosemicarbazates and uses thereof THE FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH (US) 2026-04-14 — — US disclosed
US-12595233-B2 Thiosemicarbazates and uses thereof THE FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH (US) 2026-04-07 — — US disclosed
US-20260091017-A1 TREATMENTS FOR INFLAMMATION AUCKLAND UNISERVICES LTD (NZ) 2026-04-02 — — US disclosed
US-20260077104-A1 Bioelectric Thread and Delivery Device UNIV BROWN (US) 2026-03-19 — — US disclosed
EP-4709357-A2 EXTRACELLULAR VESICLE COMPOSITIONS AND PREPARATION Virginia Tech Intellectual Properties, Inc. (US) 2026-03-18 — — EP disclosed
EP-3958886-A1 COMPOSITIONS AND METHODS FOR PROTECTING EPITHELIAL AND BARRIER INTEGRITY Ocunexus Therapeutics, Inc. (US) 2022-03-02 — — EP disclosed
CN-114126619-A Compounds for the synthesis of peptidomimetics 范因斯坦医学研究院 2022-03-01 — — CN disclosed
US-20220049275-A1 SSI CELLS WITH PREDICTABLE AND STABLE TRANSGENE EXPRESSION AND METHODS OF FORMATION LONZA AG (CH) 2022-02-17 — — US disclosed
US-20220040095-A1 AURIS FORMULATIONS FOR TREATING OTIC DISEASES AND CONDITIONS DOMPÉ FARMACEUTICI S.P.A. (IT) 2022-02-10 — — US disclosed
US-20220042064-A1 CARBON-SOURCE REGULATED PROTEIN PRODUCTION IN A RECOMBINANT HOST CELL LONZA LTD (CH) 2022-02-10 — — US disclosed
EP-3947695-A1 MUT- METHYLOTROPHIC YEAST Universität für Bodenkultur Wien (AT) 2022-02-09 — — EP disclosed
CN-114010788-A Channel modulators 奥克兰联合服务有限公司 2022-02-08 — — CN disclosed
CN-114025786-A Compositions and methods for protecting epithelial and barrier integrity 欧耐柯萨斯医疗有限公司 2022-02-08 — — CN disclosed
US-11236520-B2 Customizable facility LONZA LTD (CH) 2022-02-01 — — US disclosed
EP-3942014-A1 CONTINUOUS BLADE IMPELLER Lonza Ltd. (CH) 2022-01-26 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260091017-A1 TREATMENTS FOR INFLAMMATION P2RX7, NLRP3, PYCARD VHL 2374/4885OPRD1 3942/4885OPRM1 3404/4885
US-12624002-B2 Dimers for use in synthesis of peptidomimetics GLUL, ARGLU1, ASNS VHL 1994/4885OPRD1 905/4885OPRM1 1215/4885
US-20260077104-A1 Bioelectric Thread and Delivery Device TNNI3, TNNT2, TTN VHL 4523/4885OPRD1 3953/4885OPRM1 4673/4885
US-12595233-B2 Thiosemicarbazates and uses thereof TST, THRB, HSPB1 VHL 2336/4885OPRD1 2834/4885OPRM1 1506/4885
US-20220040095-A1 AURIS FORMULATIONS FOR TREATING OTIC DISEASES AND CONDITIONS OTC, AQP4, SLC26A4 VHL 1475/4885OPRD1 3734/4885OPRM1 3000/4885
US-12600699-B2 Thiosemicarbazates and uses thereof MET, THRB, ABAT VHL 2776/4885OPRD1 2236/4885OPRM1 780/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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