SCHEMBL343794

SCHEMBL343794

O=C(O)c1cc(OCc2ccccc2)ccc1O

nearest known ligand 0.78

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MCL1 Q07820 2/20 0.78
MAOB P27338 3/20 0.66
PTGES O14684 1/20 0.59
NR4A2 P43354 2/20 0.58
NR4A1 P22736 1/20 0.58
NR4A3 Q92570 1/20 0.58
MAOA P21397 2/20 0.57
CTSV O60911 1/20 0.57
CTSL P07711 1/20 0.57
MEN1 O00255 1/20 0.57
KMT2A Q03164 1/20 0.57
HNF4A P41235 1/20 0.57
LMNA P02545 1/20 0.56
CYP1A2 P05177 1/20 0.56
PTGS1 P23219 1/20 0.56
SLC6A2 P23975 1/20 0.56
CYP2C19 P33261 1/20 0.56
PTGS2 P35354 1/20 0.56
SLC6A3 Q01959 1/20 0.56
HIF1A Q16665 1/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13965404 0.89 MCL1 (0.64) MCL1MAOBPTGESNR4A2MAOA
SCHEMBL31580821 0.89 MCL1 (0.72) MCL1MAOBNR4A2MAOACTSV
SCHEMBL1519064 0.89 MAOB (0.77) MCL1MAOBNR4A2NR4A1NR4A3
SCHEMBL16320470 0.88 MCL1 (1.00) MCL1MAOBPTGESNR4A2NR4A1
SCHEMBL560607 0.88 MAOB (0.81) MCL1MAOBPTGESMAOALMNA
SCHEMBL14770775 0.88 MCL1 (0.62) MCL1MAOBPTGESMAOACTSV
SCHEMBL7161222 0.87 MAOB (0.65) MCL1MAOBNR4A2NR4A1NR4A3
SCHEMBL16704452 0.86 MAOB (0.60) MCL1MAOBMAOAALDH1A1
SCHEMBL13977571 0.86 RXRA (0.61) MCL1MAOBMAOAKMT2AALDH1A1
SCHEMBL14774262 0.86 RAB9A (0.61) MCL1MAOBMAOAALDH1A1SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 73 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9198886-B2 Use of 2,5-dihydroxybenzene for the treatment of ocular diseases CUEVAS SÁNCHEZ PEDRO (ES) 2015-12-01 US claimed
US-20140206654-A1 USE OF 2,5-DIHYDROXYBENZENE COMPOUNDS AND DERIVATIVES FOR THE TREATMENT OF HEMATOLOGICAL DYSCRASIAS AND CANCER OF AN ORGAN ACTION MEDICINES, S.L. (ES) 2014-07-24 US claimed
EP-2061453-B1 2,5-DIHYDROXYBENZENE COMPOUNDS FOR TREATING CANCERS AND HEMATOLOGICAL DYSCRASIAS ACTION MEDICINES SL (ES) 2013-03-13 EP claimed
US-20120015912-A1 USE OF 2,5-DIHYDROXYBENZENE FOR THE TREATMENT OF OCULAR DISEASES ACTION MEDICINES (ES) 2012-01-19 US claimed
US-20110257264-A1 USE OF 2,5-DIHYDROXYBENZENE DERIVATIVES FOR TREATING ACTINIC KERATOSIS ACTION MEDICINES (ES) 2011-10-20 US claimed
EP-2061453-A2 2,5-DIHYDROXYBENZENE COMPOUNDS FOR TREATING CANCERS AND HEMATOLOGICAL DYSCRASIAS Action Medicines, S.L. (ES) 2009-05-27 EP claimed
EP-2056805-A1 USE OF 2, 5-DIHYDROXYBENZENE DERIVATIVES FOR THE TREATMENT OF TISSUE REACTIVE DISEASES Action Medicines, S.L. (ES) 2009-05-13 EP claimed
EP-2056804-A1 USE OF 2,5-DIHYDROXYBENZENE DERIVATIVES FOR THE TREATMENT OF OCULAR DISEASES Action Medicines, S.L. (ES) 2009-05-13 EP claimed
EP-2054051-A1 USE OF 2,5-DIHYDROXYBENZENE DERIVATIVES FOR TREATING ACTINIC KERATOSIS Investread Europe, S.L. (ES) 2009-05-06 EP claimed
US-20080125485-A1 2-(acetyloxy)-5-hydroxybenzenesulfonic acid, or 5-(acetyloxy)-2-hydroxybenzene-sulfonic acid, or 2,5-bis(acetyloxy)benzenesulfonic acid; skin disorders like skin wrinkles, actinic keratosis, skin pigmentation and hyperpigmentation, hirsutism and hypertricosis, obesity due to adipogenesis ACTION MEDICINES (ES) 2008-05-29 US claimed
US-20080125486-A1 sultosilic acid, 2-(acetyloxy)-5-hydroxybenzenesulfonic acid, or 5-(acetyloxy)-2-hydroxybenzene-sulfonic acid, or 2,5-bis(acetyloxy)benzenesulfonic acid, used for improving the efficacy of chemotherapy, radiotherapy and/or cancer immunotherapy ACTION MEDICINES (ES) 2008-05-29 US claimed
US-20080114063-A1 Use of 2,5-Dihydroxybenzene Derivatives for the Treatment of Tissue Reactive Diseases ACTION MEDICINES (ES) 2008-05-15 US claimed
WO-2008020039-A2 2,5-DIHYDROXYBENZENE COMPOUNDS FOR TREATING CANCERS AND HEMATOLOGICAL DYSCRASIAS ACTION MEDICINES, S.L. (ES) 2008-02-21 WO claimed
WO-2008020031-A1 USE OF 2,5-DIHYDROXYBENZENE DERIVATIVES FOR THE TREATMENT OF ANGIOGENIC DISEASES ACTION MEDICINES, S.L. (ES) 2008-02-21 WO claimed
WO-2008020037-A1 USE OF 2,5-DIHYDROXYBENZENE DERIVATIVES FOR TREATING OBESITY, HIRSUTISM, HYPERTRICOSIS AND VIRAL WARTS ACTION MEDICINES, S.L. (ES) 2008-02-21 WO claimed
WO-2008020034-A1 USE OF 2,5-DIHYDROXYBENZENE DERIVATIVES FOR THE TREATMENT OF HEMANGIOMAS OR HEMANGIOBLASTOMAS ACTION MEDICINES, S.L. (ES) 2008-02-21 WO claimed
WO-2008020032-A1 USE OF 2,5-DIHYDROXYBENZENE DERIVATIVES FOR THE TREATMENT OF OCULAR DISEASES ACTION MEDICINES, S.L. (ES) 2008-02-21 WO claimed
WO-2008020042-A1 USE OF 2, 5-DIHYDROXYBENZENE DERIVATIVES FOR THE TREATMENT OF TISSUE REACTIVE DISEASES ACTION MEDICINES, S.L. (ES) 2008-02-21 WO claimed
WO-2008020025-A1 USE OF 2,5-DIHYDROXYBENZENE DERIVATIVES FOR TREATING ACTINIC KERATOSIS ACTION MEDICINES, S.L. (ES) 2008-02-21 WO claimed
US-20190192474-A1 Use Of 2,5-Dihydroxybenzene Compounds And Derivatives For The Treatment Of Skin Cancer AmDerma Pharmaceuticals, LLC 2019-06-27 US disclosed
US-10278940-B2 Use of 2,5-dihydroxybenzene compounds and derivatives for the treatment of skin cancer AmDerma Pharmaceuticals, LLC (US) 2019-05-07 US disclosed
EP-2710431-B1 TONER CANON KK (JP) 2017-09-13 EP disclosed
US-20170065547-A1 Use Of 2,5-Dihydroxybenzene Compounds And Derivatives For The Treatment Of Skin Cancer ACTION MEDICINES, S.L. (ES) 2017-03-09 US disclosed
US-9511044-B2 Use of 2,5-dihydroxybenzene compounds and derivatives for the treatment of skin cancer AmDerma Pharmaceuticals, LLC (US) 2016-12-06 US disclosed
US-9248114-B2 Use of 2,5-dihydroxybenzene compounds and derivatives for the treatment of hematological dyscrasias and cancer of an organ ACTION MEDICINES, S.L. (ES) 2016-02-02 US disclosed
US-9198886-B2 Use of 2,5-dihydroxybenzene for the treatment of ocular diseases CUEVAS SÁNCHEZ PEDRO (ES) 2015-12-01 US disclosed
US-9060966-B2 Use of 2,5-dihydroxybenzene derivatives for the treatment of arthritis and pain CUEVAS SÁNCHEZ PEDRO (ES) 2015-06-23 US disclosed
US-9018195-B2 Use of 2,5-dihydroxybenzene sulfonic acid compounds for treating skin photoaging AmDerma Pharmaceuticals, LLC (US) 2015-04-28 US disclosed
US-8889737-B2 Use of 2,5-dihydroxybenzene compounds and derivatives for the treatment of skin cancer AmDerma Pharmaceuticals, LLC (US) 2014-11-18 US disclosed
US-20140328823-A1 Use Of 2,5-Dihydroxybenzene Compounds And Derivatives For The Treatment Of Skin Cancer AmDerma Pharmaceuticals, LLC 2014-11-06 US disclosed
US-20140206654-A1 USE OF 2,5-DIHYDROXYBENZENE COMPOUNDS AND DERIVATIVES FOR THE TREATMENT OF HEMATOLOGICAL DYSCRASIAS AND CANCER OF AN ORGAN ACTION MEDICINES, S.L. (ES) 2014-07-24 US disclosed
US-8574801-B2 Toner CANON KABUSHIKI KAISHA (JP) 2013-11-05 US disclosed
US-8574801-B2 Toner CANON KABUSHIKI KAISHA (JP) 2013-11-05 US disclosed
US-8541467-B2 Use of 2,5-dihydroxybenzene compounds and derivatives for the treatment of hematological dyscrasias and cancer of an organ ACTION MEDICINES, S.L. (ES) 2013-09-24 US disclosed
US-20130202580-A1 Use Of 2,5-Dihydroxybenzene Derivatives For Treating Actinic Keratosis AmDerma Pharmaceuticals, LLC (US) 2013-08-08 US disclosed
US-8436045-B2 Use of 2,5-dihydroxybenzene derivatives for treating actinic keratosis AmDerma Pharmaceuticals, LLC (US) 2013-05-07 US disclosed
US-20130065174-A1 TONER CANON KABUSHIKI KAISHA (JP) 2013-03-14 US disclosed
US-20130065174-A1 TONER CANON KABUSHIKI KAISHA (JP) 2013-03-14 US disclosed
EP-2061453-B1 2,5-DIHYDROXYBENZENE COMPOUNDS FOR TREATING CANCERS AND HEMATOLOGICAL DYSCRASIAS ACTION MEDICINES SL (ES) 2013-03-13 EP disclosed
US-20120295190-A1 TONER CANON KABUSHIKI KAISHA (JP) 2012-11-22 US disclosed
US-20120295190-A1 TONER CANON KABUSHIKI KAISHA (JP) 2012-11-22 US disclosed
CN-102531905-A Novel gentisic acid derivative 2-hydroxy-5-alkyl oxybenzoic acid esters, preparation method and novel application thereof SICHUAN HUAFU BIOTECHNOLOGY CO LTD 2012-07-04 CN disclosed
US-20120087904-A1 Use Of 2,5-Dihydroxybenzene Compounds And Derivatives For The Treatment Of Skin Cancer AmDerma Pharmaceuticals, LLC (US) 2012-04-12 US disclosed
US-8101660-B2 Use of 2,5-dihydroxybenzene compounds and derivatives for the treatment of skin cancer AmDerma Pharmaceuticals, LLC (US) 2012-01-24 US disclosed
US-20120015912-A1 USE OF 2,5-DIHYDROXYBENZENE FOR THE TREATMENT OF OCULAR DISEASES ACTION MEDICINES (ES) 2012-01-19 US disclosed
US-20110257264-A1 USE OF 2,5-DIHYDROXYBENZENE DERIVATIVES FOR TREATING ACTINIC KERATOSIS ACTION MEDICINES (ES) 2011-10-20 US disclosed
US-20110152222-A1 USE OF 2,5-DIHYDROXYBENZENE DERIVATIVES FOR THE TREATMENT OF ARTHRITIS AND PAIN SANCHEZ PEDRO CUEVAS 2011-06-23 US disclosed
CN-101648919-A 3-substituted salicylamide compound, preparation method, medicinal composition and application thereof INST MATERIA MEDICA CAMS 2010-02-17 CN disclosed
EP-2061453-A2 2,5-DIHYDROXYBENZENE COMPOUNDS FOR TREATING CANCERS AND HEMATOLOGICAL DYSCRASIAS Action Medicines, S.L. (ES) 2009-05-27 EP disclosed
EP-2056804-A1 USE OF 2,5-DIHYDROXYBENZENE DERIVATIVES FOR THE TREATMENT OF OCULAR DISEASES Action Medicines, S.L. (ES) 2009-05-13 EP disclosed
EP-2056805-A1 USE OF 2, 5-DIHYDROXYBENZENE DERIVATIVES FOR THE TREATMENT OF TISSUE REACTIVE DISEASES Action Medicines, S.L. (ES) 2009-05-13 EP disclosed
EP-2054045-A1 USE OF 2,5-DIHYDROXYBENZENE DERIVATIVES FOR THE TREATMENT OF ARTHRITIS AND PAIN Action Medicines, S.L. (ES) 2009-05-06 EP disclosed
EP-2054051-A1 USE OF 2,5-DIHYDROXYBENZENE DERIVATIVES FOR TREATING ACTINIC KERATOSIS Investread Europe, S.L. (ES) 2009-05-06 EP disclosed
US-20080125485-A1 2-(acetyloxy)-5-hydroxybenzenesulfonic acid, or 5-(acetyloxy)-2-hydroxybenzene-sulfonic acid, or 2,5-bis(acetyloxy)benzenesulfonic acid; skin disorders like skin wrinkles, actinic keratosis, skin pigmentation and hyperpigmentation, hirsutism and hypertricosis, obesity due to adipogenesis ACTION MEDICINES (ES) 2008-05-29 US disclosed
US-20080125486-A1 sultosilic acid, 2-(acetyloxy)-5-hydroxybenzenesulfonic acid, or 5-(acetyloxy)-2-hydroxybenzene-sulfonic acid, or 2,5-bis(acetyloxy)benzenesulfonic acid, used for improving the efficacy of chemotherapy, radiotherapy and/or cancer immunotherapy ACTION MEDICINES (ES) 2008-05-29 US disclosed
US-20080114063-A1 Use of 2,5-Dihydroxybenzene Derivatives for the Treatment of Tissue Reactive Diseases ACTION MEDICINES (ES) 2008-05-15 US disclosed
US-20080114060-A1 2-(acetyloxy)-5-hydroxybenzenesulfonic acid, or 5-(acetyloxy)-2-hydroxybenzene-sulfonic acid, or 2,5-bis(acetyloxy)benzenesulfonic acid, or sultosilic acid for example; combination therapy with other drugs or photodynamic therapy ACTION MEDICINES (ES) 2008-05-15 US disclosed
WO-2008020039-A2 2,5-DIHYDROXYBENZENE COMPOUNDS FOR TREATING CANCERS AND HEMATOLOGICAL DYSCRASIAS ACTION MEDICINES, S.L. (ES) 2008-02-21 WO disclosed
WO-2008020027-A2 2,5-DIHYDROXYBENZENE COMPOUNDS FOR THE TREATMENT OF SKIN CANCER ACTION MEDICINES, S.L. (ES) 2008-02-21 WO disclosed
WO-2008020031-A1 USE OF 2,5-DIHYDROXYBENZENE DERIVATIVES FOR THE TREATMENT OF ANGIOGENIC DISEASES ACTION MEDICINES, S.L. (ES) 2008-02-21 WO disclosed
WO-2008020037-A1 USE OF 2,5-DIHYDROXYBENZENE DERIVATIVES FOR TREATING OBESITY, HIRSUTISM, HYPERTRICOSIS AND VIRAL WARTS ACTION MEDICINES, S.L. (ES) 2008-02-21 WO disclosed
WO-2008020034-A1 USE OF 2,5-DIHYDROXYBENZENE DERIVATIVES FOR THE TREATMENT OF HEMANGIOMAS OR HEMANGIOBLASTOMAS ACTION MEDICINES, S.L. (ES) 2008-02-21 WO disclosed
WO-2008020040-A2 2,5-DIHYDROXYBENZENE COMPOUNDS FOR THE TREATMENT OF FIBROSIS ACTION MEDICINES, S.L. (ES) 2008-02-21 WO disclosed
WO-2008020033-A1 USE OF 2,5-DIHYDROXYBENZENE DERIVATIVES FOR THE TREATMENT OF ARTHRITIS AND PAIN ACTION MEDICINES, S.L. (ES) 2008-02-21 WO disclosed
WO-2008020032-A1 USE OF 2,5-DIHYDROXYBENZENE DERIVATIVES FOR THE TREATMENT OF OCULAR DISEASES ACTION MEDICINES, S.L. (ES) 2008-02-21 WO disclosed
WO-2008020042-A1 USE OF 2, 5-DIHYDROXYBENZENE DERIVATIVES FOR THE TREATMENT OF TISSUE REACTIVE DISEASES ACTION MEDICINES, S.L. (ES) 2008-02-21 WO disclosed
WO-2008020025-A1 USE OF 2,5-DIHYDROXYBENZENE DERIVATIVES FOR TREATING ACTINIC KERATOSIS ACTION MEDICINES, S.L. (ES) 2008-02-21 WO disclosed
US-4355070-A COLOR FORMER, DEVELOPER, HEAT FUSIBLE MATERIAL AND OIL ABSORPTIVE PIGMENT KANZAKI PAPER MANUFACTURING CO., LTD. (JP) 1982-10-19 US disclosed
US-4311758-A INORGANIC PIGMENTS IN THE COLOR DEVELOPER LAYER KANZAKI PAPER MANUFACTURING CO., LTD. (JP) 1982-01-19 US disclosed
US-4236732-A COLOR DEVELOPING LAYER CONTAINING PARTICLES OF A CHROMOGENIC MATERIAL, AN ACCEPTOR AND A HEAT FUSIBLE MATERIAL KANZAKI PAPER MANUFACTURING CO., LTD. (JP) 1980-12-02 US disclosed
US-4228222-A COLOR DEVELOPING LAYER INCLUDING WATER SOLUBLE RESIN AS BINDER KANZAKI PAPER MANUFACTURING CO., LTD. (JP) 1980-10-14 US disclosed
US-4168845-A Heat-sensitive record material KANZAKI PAPER MANUFACTURING CO., LTD. (JP) 1979-09-25 US disclosed
US-3983292-A Pressure sensitive recording papers SANKO CHEMICAL COMPANY LTD. (JA) 1976-09-28 US disclosed
US-3983292-A Pressure sensitive recording papers SANKO CHEMICAL COMPANY LTD. (JA) 1976-09-28 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (14 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080125485-A1 2-(acetyloxy)-5-hydroxybenzenesulfonic acid, or 5-(acetyloxy)-2-hydroxybenzene-sulfonic acid, or 2,5-bis(acetyloxy)benzenesulfonic acid; skin disorders like skin wrinkles, actinic keratosis, skin pigmentation and hyperpigmentation, hirsutism and hypertricosis, obesity due to adipogenesis ARSA, CYP8B1, EBP MCL1 2983/4885MAOB 469/4885PTGES 2493/4885
US-20080125486-A1 sultosilic acid, 2-(acetyloxy)-5-hydroxybenzenesulfonic acid, or 5-(acetyloxy)-2-hydroxybenzene-sulfonic acid, or 2,5-bis(acetyloxy)benzenesulfonic acid, used for improving the efficacy of chemotherapy, radiotherapy and/or cancer immunotherapy STS, MPST, TST MCL1 158/4885MAOB 4449/4885PTGES 3121/4885
US-20140328823-A1 Use Of 2,5-Dihydroxybenzene Compounds And Derivatives For The Treatment Of Skin Cancer CYP8B1, CYP26B1, CYP24A1 MCL1 1572/4885MAOB 278/4885PTGES 2789/4885
US-20120087904-A1 Use Of 2,5-Dihydroxybenzene Compounds And Derivatives For The Treatment Of Skin Cancer CYP8B1, CYP26B1, CYP24A1 MCL1 1572/4885MAOB 278/4885PTGES 2789/4885
US-10278940-B2 Use of 2,5-dihydroxybenzene compounds and derivatives for the treatment of skin cancer CYP8B1, CYP26B1, CYP24A1 MCL1 1572/4885MAOB 278/4885PTGES 2789/4885
US-20130202580-A1 Use Of 2,5-Dihydroxybenzene Derivatives For Treating Actinic Keratosis CYP8B1, DERA, KRT18 MCL1 3242/4885MAOB 489/4885PTGES 2900/4885
US-20080114063-A1 Use of 2,5-Dihydroxybenzene Derivatives for the Treatment of Tissue Reactive Diseases CYP11B1, CYP11B2, MYLK MCL1 2466/4885MAOB 102/4885PTGES 526/4885
US-20170065547-A1 Use Of 2,5-Dihydroxybenzene Compounds And Derivatives For The Treatment Of Skin Cancer CYP8B1, CYP26B1, CYP24A1 MCL1 1572/4885MAOB 278/4885PTGES 2789/4885
US-20120015912-A1 USE OF 2,5-DIHYDROXYBENZENE FOR THE TREATMENT OF OCULAR DISEASES ALDH1A2, CRYAB, HSD17B14 MCL1 4435/4885MAOB 139/4885PTGES 1450/4885
US-20190192474-A1 Use Of 2,5-Dihydroxybenzene Compounds And Derivatives For The Treatment Of Skin Cancer CYP8B1, CYP26B1, CYP24A1 MCL1 1572/4885MAOB 278/4885PTGES 2789/4885
US-20080114060-A1 2-(acetyloxy)-5-hydroxybenzenesulfonic acid, or 5-(acetyloxy)-2-hydroxybenzene-sulfonic acid, or 2,5-bis(acetyloxy)benzenesulfonic acid, or sultosilic acid for example; combination therapy with other drugs or photodynamic therapy ALAD, ARSA, STS MCL1 1455/4885MAOB 2552/4885PTGES 602/4885
US-20140206654-A1 USE OF 2,5-DIHYDROXYBENZENE COMPOUNDS AND DERIVATIVES FOR THE TREATMENT OF HEMATOLOGICAL DYSCRASIAS AND CANCER OF AN ORGAN HMBS, HCLS1, CYP2S1 MCL1 34/4885MAOB 1464/4885PTGES 4611/4885
US-20110257264-A1 USE OF 2,5-DIHYDROXYBENZENE DERIVATIVES FOR TREATING ACTINIC KERATOSIS CYP8B1, DERA, KRT18 MCL1 3242/4885MAOB 489/4885PTGES 2900/4885
US-20110152222-A1 USE OF 2,5-DIHYDROXYBENZENE DERIVATIVES FOR THE TREATMENT OF ARTHRITIS AND PAIN CYP8B1, CYP26B1, UGT2B7 MCL1 2904/4885MAOB 118/4885PTGES 526/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.