Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 4/20 | 0.70 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | NAMPT | P43490 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6334721 | 0.91 | TRPM8 (0.73) | TRPM8ALDH1A1GAASMN1; SMN2HTT | |
| SCHEMBL19189293 | 0.89 | TRPM8 (0.70) | TRPM8TRPV1ALDH1A1GAASMN1; SMN2 | |
| SCHEMBL2628679 | 0.88 | TRPM8 (0.69) | TRPM8ALDH1A1SMN1; SMN2LMNATP53 | |
| SCHEMBL663340 | 0.88 | TRPM8 (0.69) | TRPM8ALDH1A1SMN1; SMN2LMNATP53 | |
| SCHEMBL10072945 | 0.88 | TRPM8 (0.69) | TRPM8TRPV1GAAHTTMAPT | |
| SCHEMBL5448215 | 0.85 | TRPM8 (0.64) | TRPM8TRPV1ALDH1A1GAASMN1; SMN2 | |
| SCHEMBL4883161 | 0.85 | TRPM8 (0.67) | TRPM8TRPV1ALDH1A1GAASMN1; SMN2 | |
| SCHEMBL2628770 | 0.83 | TRPM8 (0.67) | TRPM8TRPV1ALDH1A1LMNATP53 | |
| Acoltremon SCHEMBL23198293 | 0.82 | TRPM8 (1.00) | TRPM8TRPV1ALDH1A1SMN1; SMN2MEN1 | |
| Acoltremon SCHEMBL619824 | 0.82 | TRPM8 (1.00) | TRPM8TRPV1ALDH1A1SMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 260 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112423729-B | Oral care compositions with improved efficacy of deposition of cooling sensates in the oral cavity | 宝洁公司 | 2023-07-11 | — | — | CN | claimed |
| CN-113133950-A | Composition and solution for refreshing and relieving fatigue and application thereof | 深圳全棉时代科技有限公司 | 2021-07-20 | — | — | CN | claimed |
| CN-112423729-A | Oral care compositions with improved deposition of cooling sensates in the oral cavity | 宝洁公司 | 2021-02-26 | — | — | CN | claimed |
| US-10871363-B2 | Oral care composition with improved deposition efficacy of a cooling sensate agent in the oral cavity | THE PROCTER & GAMBLE COMPANY (US) | 2020-12-22 | — | — | US | claimed |
| EP-3134081-B1 | CYCLOHEXANECARBOXAMIDE WITH COOLING PROPERTIES | PROCTER & GAMBLE (US) | 2020-04-22 | — | — | EP | claimed |
| US-20190276389-A1 | SYNTHESIS OF ARYL CYCLOHEXANE ESTER DERIVATIVES USEFUL AS SENSATES IN CONSUMER PRODUCTS | THE PROCTER & GAMBLE COMPANY | 2019-09-12 | — | — | US | claimed |
| EP-3390352-A1 | SYNTHESIS OF CYCLOHEXANE ESTER DERIVATIVES USEFUL AS SENSATES IN CONSUMER PRODUCTS | The Procter and Gamble Company (US) | 2018-10-24 | — | — | EP | claimed |
| WO-2017106279-A1 | SYNTHESIS OF CYCLOHEXANE ESTER DERIVATIVES USEFUL AS SENSATES IN CONSUMER PRODUCTS | THE PROCTER & GAMBLE COMPANY (US) | 2017-06-22 | — | — | WO | claimed |
| US-20170119639-A1 | COMPOSITIONS FOR DEPOSITION ON BIOLOGICAL SURFACES | PROCTER & GAMBLE (US) | 2017-05-04 | — | — | US | claimed |
| EP-3134081-A2 | CYCLOHEXANECARBOXAMIDE WITH COOLING PROPERTIES | The Procter & Gamble Company (US) | 2017-03-01 | — | — | EP | claimed |
| WO-2016036423-A2 | COMPOSITIONS FOR DEPOSITION ON BIOLOGICAL SURFACES | THE PROCTER & GAMBLE COMPANY (US) | 2016-03-10 | — | — | WO | claimed |
| US-20150307447-A1 | COMPOSITIONS FOR DEPOSITION ON BIOLOGICAL SURFACES | THE PROCTER & GAMBLE COMPANY | 2015-10-29 | — | — | US | claimed |
| EP-2244745-B1 | ABSORBENT ARTICLE COMPRISING LOTION COMPOSITION COMPRISING A COOLING AGENT | PROCTER & GAMBLE (US) | 2015-03-25 | — | — | EP | claimed |
| US-RE44339-E1 | N-substituted P-menthane carboxamides | GIVAUDAN S.A. (CH) | 2013-07-02 | — | — | US | claimed |
| EP-2533760-A1 | LIQUID COMPOSITION COMPRISING A NON-MENTHOL COOLING AGENT AND A THICKENER FOR TREATING A RESPIRATORY SYMPTOM | The Procter & Gamble Company (US) | 2012-12-19 | — | — | EP | claimed |
| WO-2011100267-A1 | LIQUID COMPOSITION COMPRISING A NON-MENTHOL COOLING AGENT AND A THICKENER FOR TREATING A RESPIRATORY SYMPTOM | THE PROCTER & GAMBLE COMPANY (US) | 2011-08-18 | — | — | WO | claimed |
| US-20110195042-A1 | Compositions, Methods and Kits Useful for Treating a Respiratory Symptom | THE PROCTER & GAMBLE COMPANY | 2011-08-11 | — | — | US | claimed |
| US-20090240223-A1 | ABSORBENT ARTICLE COMPRISING LOTION COMPOSITION COMPRISING A COOLING AGENT | PROCTER & GAMBLE COMPANY, THE | 2009-09-24 | — | — | US | claimed |
| US-7414152-B2 | e. g. N-(4-cyanomethylphenyl) p-menthanecarboxamide; cooling agent in cosmetics and food industries; with additional cooling compound such as menthol, menthone, isopulegol | GIVAUDAN, SA (CH) | 2008-08-19 | — | — | US | claimed |
| US-20060276667-A1 | N-substituted p-menthane carboxamides | GIVAUDAN-SA | 2006-12-07 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170119639-A1 | COMPOSITIONS FOR DEPOSITION ON BIOLOGICAL SURFACES | CUTA, TAS2R40, TAS2R20 | TRPM8 54/4885TRPV1 43/4885ALDH1A1 3098/4885 |
| US-20110195042-A1 | Compositions, Methods and Kits Useful for Treating a Respiratory Symptom | MUC1, TAS2R42, TAS2R7 | TRPM8 34/4885TRPV1 48/4885ALDH1A1 4005/4885 |
| US-20150307447-A1 | COMPOSITIONS FOR DEPOSITION ON BIOLOGICAL SURFACES | CUTA, TAS2R40, TAS2R20 | TRPM8 54/4885TRPV1 43/4885ALDH1A1 3098/4885 |
| US-20060276667-A1 | N-substituted p-menthane carboxamides | ME2, ME3, PYM1 | TRPM8 45/4885TRPV1 149/4885ALDH1A1 2217/4885 |
| US-20190276389-A1 | SYNTHESIS OF ARYL CYCLOHEXANE ESTER DERIVATIVES USEFUL AS SENSATES IN CONSUMER PRODUCTS | CUTA, TAS2R8, TRPA1 | TRPM8 39/4885TRPV1 32/4885ALDH1A1 1425/4885 |
| US-10871363-B2 | Oral care composition with improved deposition efficacy of a cooling sensate agent in the oral cavity | ORAI1, TRPM4, TRPM7 | TRPM8 11/4885TRPV1 57/4885ALDH1A1 3988/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.