Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN8A known ✓ | Q9UQD0 | 3/20 | 0.42 |
| ▸ | SCN4A known ✓ | P35499 | 3/20 | 0.41 |
| ▸ | SCN1A known ✓ | P35498 | 1/20 | 0.41 |
| ▸ | SCN7A known ✓ | Q01118 | 1/20 | 0.41 |
| ▸ | SCN5A known ✓ | Q14524 | 1/20 | 0.41 |
| ▸ | SCN9A known ✓ | Q15858 | 1/20 | 0.41 |
| ▸ | SCN2A known ✓ | Q99250 | 1/20 | 0.41 |
| ▸ | SCN3A known ✓ | Q9NY46 | 1/20 | 0.41 |
| ▸ | SCN11A known ✓ | Q9UI33 | 1/20 | 0.41 |
| ▸ | SCN10A known ✓ | Q9Y5Y9 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1751992 | 0.81 | L3MBTL1 (0.55) | KMT2AMEN1L3MBTL1ALDH1A1KDM4E | |
| SCHEMBL7379938 | 0.80 | SCN4A (0.46) | KMT2AMEN1L3MBTL1ALDH1A1KDM4E | |
| SCHEMBL15048558 | 0.75 | ALDH1A1 (0.51) | KMT2AMEN1L3MBTL1ALDH1A1KDM4E | |
| SCHEMBL11326783 | 0.73 | MAPT (0.52) | KMT2AMEN1L3MBTL1ALDH1A1KDM4E | |
| SCHEMBL515980 | 0.72 | ALDH1A1 (0.61) | KMT2AMEN1ALDH1A1KDM4ESCN8A | |
| SCHEMBL21595893 | 0.71 | L3MBTL1 (0.67) | KMT2AMEN1L3MBTL1ALDH1A1KDM4E | |
| SCHEMBL18467924 | 0.71 | L3MBTL1 (0.47) | KMT2AMEN1L3MBTL1SCN8ASMN1; SMN2 | |
| SCHEMBL14499026 | 0.71 | KMT2A (0.57) | KMT2AMEN1L3MBTL1ALDH1A1SCN8A | |
| SCHEMBL11571463 | 0.70 | SMN1; SMN2 (0.50) | KMT2AMEN1L3MBTL1ALDH1A1KDM4E | |
| SCHEMBL1991553 | 0.70 | ALDH1A1 (0.52) | KMT2AMEN1ALDH1A1KDM4ESCN8A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2053918-B1 | PROPYL PHENOXY ETHERS FOR USE AS DELIVERY AGENTS | EMISPHERE TECH INC (US) | 2014-07-23 | — | — | EP | disclosed |
| US-20100062970-A1 | SYNTHESIS OF PROPYL PHENOXY ETHERS AND USE AS DELIVERY AGENTS | EMISPHERE TECHNOLOGIES INC. (US) | 2010-03-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100062970-A1 | SYNTHESIS OF PROPYL PHENOXY ETHERS AND USE AS DELIVERY AGENTS | EPX, HPD, CYP2C8 | SCN8A 3435/4885SCN4A 2534/4885SCN1A 3989/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.