Sugi Predict

Sugi Predict / Compounds / SCHEMBL3787388

SCHEMBL3787388

SCHEMBL3787388

OB(O)c1ccc(C2CCC2)cc1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ESR2 Q92731 9/20 0.47
▸ ESR1 P03372 5/20 0.43
▸ CYP3A4 P08684 1/20 0.43
▸ CYP2D6 P10635 1/20 0.43
▸ CYP2C9 P11712 1/20 0.43
▸ ENPP2 Q13822 3/20 0.42
▸ KDM4E B2RXH2 1/20 0.41
▸ HDAC1 Q13547 1/20 0.41
▸ HDAC8 Q9BY41 1/20 0.41
▸ HDAC6 Q9UBN7 1/20 0.41
▸ HIF1A Q16665 1/20 0.41
▸ CA2 P00918 2/20 0.41
▸ CA1 P00915 1/20 0.41
▸ TSHR P16473 1/20 0.41
▸ LPL P06858 1/20 0.41
▸ LIPG Q9Y5X9 1/20 0.41
▸ CA4 P22748 1/20 0.39
▸ CA6 P23280 1/20 0.39
▸ CA5A P35218 1/20 0.39
▸ CA7 P43166 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3289787 0.95 HDAC1 (0.46) ESR2ESR1CYP3A4CYP2D6CYP2C9
SCHEMBL257745 0.93 HIF1A (0.46) ESR2ENPP2KDM4EHDAC1HDAC8
SCHEMBL17070208 0.93 HIF1A (0.46) ESR2ENPP2KDM4EHDAC1HDAC8
SCHEMBL938629 0.91 ESR2 (0.46) ESR2ESR1CYP3A4CYP2C9ENPP2
SCHEMBL13986748 0.81 ESR2 (0.62) ESR2ESR1CYP3A4CYP2C9ENPP2
SCHEMBL18394111 0.81 ESR2 (0.39) ESR2ESR1CYP3A4CYP2C9ENPP2
SCHEMBL16936665 0.81 ENPP2 (0.38) ESR2ENPP2HIF1ACA2CA1
SCHEMBL5886587 0.80 ESR2 (0.56) ESR2ESR1CYP3A4CYP2D6CYP2C9
SCHEMBL25353933 0.79 ENPP2 (0.37) ESR2ENPP2KDM4EHIF1ACA2
SCHEMBL3790025 0.79 ESR2 (0.35) ESR2ESR1CYP3A4CYP2D6CYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260103459-A1 SUBSTITUTED AZACYLES AS TRPM8 MODULATORS GIVAUDAN SA (CH) 2026-04-16 — — US disclosed
US-12528801-B2 Substituted azacyles as TRPM8 modulators GIVAUDAN SA (CH) 2026-01-20 — — US disclosed
US-12398120-B2 Substituted hydantoinamides as ADAMTS7 antagonists BAYER AKTIENGESELLSCHAFT (DE) 2025-08-26 — — US disclosed
US-20250145561-A1 4-SUBSTITUTED-PHENYL ACETAMIDES AND ARYLUREAS AS AGONISTS FOR THE ORPHAN RECEPTOR GPR88 RESEARCH TRIANGLE INSTITUTE (US) 2025-05-08 — — US disclosed
CN-116102478-B Preparation method of 1, 4-dicarbonyl thiosemicarbazide compound and anti-infection application 中国医学科学院药物研究所 2025-04-15 — — CN disclosed
CN-114555594-B Substituted azacycles as TRMP modulators 奇华顿股份有限公司 2025-03-18 — — CN disclosed
EP-4469431-A1 4-SUBSTITUTED-PHENYL ACETAMIDES AND ARYLUREAS AS AGONISTS FOR THE ORPHAN RECEPTOR GPR88 Research Triangle Institute (US) 2024-12-04 — — EP disclosed
CN-118541348-A 4-Substituted-phenylacetamides and aryl ureas as agonists of the orphan receptor GPR88 研究三角协会 2024-08-23 — — CN disclosed
EP-4058448-B1 HYDANTOIN DERIVATIVES AS ADAMTS7 ANTAGONISTS FOR THE TREATMENT OF CARDIOVASCULAR DISEASES BAYER AG (DE) 2024-05-29 — — EP disclosed
US-20240132487-A1 SUBSTITUTED AZACYLES AS TRMP8 MODULATORS GIVAUDAN SA (CH) 2024-04-25 — — US disclosed
CN-114555594-A Substituted azaheterocycles as TRMP8 modulators 奇华顿股份有限公司 2022-05-27 — — CN disclosed
US-20210238184-A1 THERAPEUTIC COMPOUNDS GENENTECH, INC. (US) 2021-08-05 — — US disclosed
WO-2021094436-A1 SUBSTITUTED HYDANTOINAMIDES AS ADAMTS7 ANTAGONISTS BAYER AKTIENGESELLSCHAFT (DE) 2021-05-20 — — WO disclosed
EP-3822268-A1 SUBSTITUTED HYDANTOINAMIDES AS ADAMTS7 ANTAGONISTS Bayer Aktiengesellschaft (DE) 2021-05-19 — — EP disclosed
WO-2021074281-A1 SUBSTITUTED AZACYLES AS TRMP8 MODULATORS GIVAUDAN SA (CH) 2021-04-22 — — WO disclosed
EP-3802543-A1 THERAPEUTIC COMPOUNDS F. Hoffmann-La Roche AG (CH) 2021-04-14 — — EP disclosed
CN-112204029-A Therapeutic compounds 豪夫迈·罗氏有限公司 2021-01-08 — — CN disclosed
US-20100087680-A1 METHOD FOR PRODUCING BIARYL COMPOUND SUMITOMO CHEMICAL COMPANY LIMITED (JP) 2010-04-08 — — US disclosed
EP-1914221-A1 PROCESS FOR PRODUCING BIARYL COMPOUND Sumitomo Chemical Company, Limited (JP) 2008-04-23 — — EP disclosed
WO-2005019229-A1 PROCESS FOR PURIFICATION OF BORONIC ACID AND ITS DERIVATIVES BIOCON LIMITED (IN) 2005-03-03 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260103459-A1 SUBSTITUTED AZACYLES AS TRPM8 MODULATORS TRPM8, TRPM7, TRPM5 ESR2 1993/4885ESR1 3261/4885CYP3A4 2317/4885
US-20240132487-A1 SUBSTITUTED AZACYLES AS TRMP8 MODULATORS TRPM8, TRPM7, TRPM5 ESR2 2495/4885ESR1 3803/4885CYP3A4 1746/4885
US-20100087680-A1 METHOD FOR PRODUCING BIARYL COMPOUND NISCH, BLVRB, BBOX1 ESR2 2747/4885ESR1 2272/4885CYP3A4 177/4885
US-12398120-B2 Substituted hydantoinamides as ADAMTS7 antagonists ADAMTS7, MMP7, ADAM17 ESR2 2891/4885ESR1 2415/4885CYP3A4 3418/4885
US-12528801-B2 Substituted azacyles as TRPM8 modulators TRPM8, TRPM7, TRPM4 ESR2 1803/4885ESR1 2638/4885CYP3A4 2442/4885
US-20250145561-A1 4-SUBSTITUTED-PHENYL ACETAMIDES AND ARYLUREAS AS AGONISTS FOR THE ORPHAN RECEPTOR GPR88 GPR88, GPR84, GPR139 ESR2 761/4885ESR1 841/4885CYP3A4 1510/4885
US-20210238184-A1 THERAPEUTIC COMPOUNDS YAP1, YES1, KRAS ESR2 2039/4885ESR1 1878/4885CYP3A4 4455/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.